Article considers the results of  the studies of daily monitoring parameters of arterial pressure, lipid spectrum condition, contents of serum endotheline-1 level in 120 patients with arterial hypertension, hormonal status of females. Also the influence of antihypertensive irbesartan therapy at investigated indexes. Gender and age differencies of the dynamic of aterogenous lipid spectrum and endotheline-1 fractions’contents were fixed. Irbesartan therapy is accompanied by significant improvement of blood pressure daily profiles in all groups of examined patients; maximal efficacy is fixed in postmenopausal female group. Also takes place the decrease of endotheline-1 level in comparison with start indexes , statistically more valid in males and females older than 50 y.o.

Keywords: gender diversities, lipid spectrum, irbesartan, endothelial dysfunction, arterial hypertension