Indicators of immunogenicity of influenza vaccine in HIV-infected patients seronegative to influenza virus


R.G. Yapparov, D.A. Lioznov, E.Yu. Karnaukhova, T.L. Galankin, T.V. Antonova

1 Republican center for prevention and control of AIDS and infectious diseases, Bashkortostan Republic, Ufa, Russia; 2 Research Institute of Influenza, Saint Petersburg, Russia; 3 Pavlov First State Medical University, Saint Petersburg, Russia
The immune response to standard scheme of seasonal vaccination against influenza was evaluated in HIV-infected patients without specific antibodies to influenza virus before vaccination. Titers of hemagglutinating antibodies to antigens of influenza virus A (H1N1), A (H3N2) and B were detected in standard agglutination inhibition test: before vaccination (day 0) and after it (on 21th and 150th days). Coefficient of seroconversion varied from 1.6to 2.3, seroconversion rate varied from 0to 25%); seroprotection rate — from 67% to A (H1N1) to 100% to A (H3N2) and B. Titer of antibodies detected on day 21 retained in all cases up to day 150 after vaccination. The minimal protective level of antibodies (1/40) was detected in the majority of vaccinated persons, including the at least fourfold increase of it in patients with CD4-cells level more than 350/μl.
Keywords: HIV-infection, immunogenicity, influenza, vaccination
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    • About the Autors

    Rafael’ G. Yapparov, chief doctor, infectiologist of State Budgetary Educational Institution of Higher Education “Republican center for the prevention and control of AIDS and infectious diseases” of Bashkortostan Republic.
    Tel.: +73472511136. Е-mail: rafdok@yandex.ru
     
    Dmitry A. Lioznov, MD, deputy director for science of Federal State Budgetary Institution “Research institute of gripppe” of the Ministry of Health of Russia, head of the Department 0f infectious diseases and epidemiology of Federal State Budgetary Educational Institution of Higher Education “ I.P. Pavlov First St. Petersburg state medical university” of the Ministry of Healthcare of Russia. Тel.: +78123387058. Е-mail: dlioznov@yandex.ru
     
    Elena Yu. Karnaukhova, PhD, assistant professor of the Department of infectious diseases and epidemiology of Federal State Budgetary Educational Institution of Higher Education “I.P. Pavlov First St. Petersburg state medical university” of the Ministry of Healthcare of Russia. Е-mail: elena_yk@list.ru
     
    Timofey L. Galankin, PhD, head of the laboratory of pharmacoepidemiology and pharmacocinetics of Federal State Budgetary Educational Institution of Higher Education “I.P. Pavlov First St. Petersburg state medical university” of the Ministry of Healthcare of Russia. Е-mail: galankint@gmail.com
     
    Tamara V. Antonova, MD, professor, professor of the Department of knfectious diseases and epidemiology of Federal State Budgetary Educational Institution of Higher Education “I.P. Pavlov First St. Petersburg state medical university” of the Ministry of Healthcare of Russia. Е-mail: antonovatv28@yandex.ru


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