The phenotype of knee joint osteoarthritis in 60 years old and more patients (results of the multicenter ULA study)


DOI: https://dx.doi.org/10.18565/therapy.2018.5.83-90

I.A. Zolotovskaya, I.L. Davydkin, N.Ju. Grigoryeva, L.V. Tribuntseva, I.A. Volkorezov

1 FSBEI of Higher Education «Samara state medical university» of the Ministry of Healthcare of Russia, Samara, Russia; 2 FSBEI of Higher Education «Privolzhsky research medical university» of the Ministry of Healthcare of Russia, Nizhny Novgorod, Russia; 3 FSBEI of Higher Education «N.N.Burdenko Voronezh state medical university» of the Ministry of Healthcare of Russia, Voronezh, Russia; 4 State healthcare institution «Lipetsk state polyclinic 7», Lipetsk, Russia
The purpose of the study, registered as an observational program ULA and performed between October 2017 and March 2018 on the basis of outpatient clinics in Samara, Voronezh, Lipetsk and Nizhny Novgorod, was the study of the prevalence of concomitant diseases in patients with osteoarthritis (OA) of the knee joint over the age of 60 years. Material and methods. Inclusion / non-inclusion criteria were used in 499 patients (68.0 [65.0, 72.0] years old) in whom were evaluated clinical and demographic data, as well as information on taken medications. Results. According to the analysis of the results, we found that patients with OA over the age of 60 have many comorbidities, including cardiovascular, diabetes (34.3%), chronic kidney disease (36.3%), diabetic polyneuropathy (17.4% %), gastric ulcer (11.2%), chronic gastritis (18.8%), osteoporosis / osteopenia (10.2%), anemia (19.6%), Parkinson’s disease (8.2%), glaucoma (10.8%), adenoma of the prostate (8.2%), also they are accepting a wide range of drugs. The highest percentage of drugs is in antihypertensive drugs (calcium channel blockers - 37.0%, ACEI - 40.7%, sartans - 38.3%), diuretics (35.0%), statins (43.0%), β -adrenoceptor blockers (16.2%), α-adrenoblockers (13.0%), sugar-reducing medicaments (25.9%). The level of pain in the knee joint according to the VAS consisted 55.5 ± 12.5 mm, in 31.3% of cases the pain was neuropathic, the average duration of the OA history was 7.0 ± 2.5 years. 92,5% of patients had a history of lower back pain. The conclusion. Obtained data allow to propose for discussion a degenerative-dystrophic phenotype of a patient with OA over 60 years old with a high prevalence of concomitant diseases and wide range of taken medicines in order to formulate a methodology by doctor for making a reasonable decision on the tactics of such patients’ curation.
Keywords: knee osteoarthritis, lower back pain, degenerative-dystrophic phenotype, non-steroidal anti-inflammatory medicines, neuropathic pain
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    • About the Autors

    Irina A. Zolotovskaya, PhD, associate professor of the hospital therapy with courses of out-patient therapy and transfusiology Department of FSBEI of Higher Education «Samara state medical university» of the Ministry of Healthcare of Russia. Tel .: +7 927 7687894. E-mail: zolotovskay@list.ru.
    Igor L. Davydkin, MD, Professor, pro-rector for scientific and innovative work, head of the Department of hospital therapy with polyclinic therapy and transfusiology, director of the Research Institute of Hematology, Transfusiology and Intensive Care FSBEI of Higher Education «Samara State Medical University» of the Ministry of Healthcare of Russia, the chief visiting hematologist of the Ministry of Healthcare of the Samara region. Tel .: + 79270145544. E-mail: dagi2006@rambler.ru.
    Natalia Ju. Grigoryeva, MD, professor of the Department of faculty and polyclinic therapy of FSBEI of Higher Education «Privolzhsky research medical university» of the Ministry of Healthcare of Russia. Tel .: +79056674096. E-mail: grigoreva28@mail.ru.
    Lyudmila V. Tribuntseva, MD, associate professor of the Department of general medical practice (family medicine) and medical examination of FSBEI of Higher Education «N.N. Burdenko Voronezh state medical university» of the Ministry of Healthcare of Russia. E-mail: tribunzewa@yandex.ru.
    Igor A. Volkorezov, MD, rheumatologist of State healthcare institution «Lipetsk state polyclinic 7», Lipetsk, Russia.

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