Mast cell proteases in specific tissular microenvironment formation: pathogenetic and diagnostical aspects


DOI: https://dx.doi.org/10.18565/therapy.2018.6.128-140

D.A. Atyakshin, I.B. Bukhvalov, M. Timann

1 Research Institute of Experimental Biology and Medicine, Voronezh N. N. Burdenko State Medical University, Voronezh, Russia; 2 Institute of Hematopathology, Hamburg, Germany.
Proteases make up a large part of the mast cell secretom. The biological effects of tryptase and chymase are depending on the secretory pathways of degranulation and have a selective inductive effect on the components of the specific tissue microenvironment in the mechanisms of allergic and inflammatory reactions, angiogenesis and oncogenesis, remodeling of the extracellular matrix of connective tissue with alteration of the organ histoarchitectonics. The polyfunctionality of proteases allows more fully disclose the significance of mast cells in the development of physiological and pathological reactions while performing molecular morphological analysis; tryptase and chymase are considered to be not only as informative diagnostic markers of a number of diseases, but also as a promising pharmacological target during therapy application.
Keywords: mast cells, tryptase, chymase, secretion, tissue microenvironment, inflammation
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    • About the Autors

    Dmitry A. Atiakshin, MD, director of the research institute of experimental biology and medicine, N.N. Burdenko VSMU, head of the laboratory of molecular morphology and immune histochemistry, associate professor of the Department of histology. 394000, Voronezh, 10 Studentsheskaya St. Tel. +79036501853. E-mail: Earth-mars38@yandex.ru
    Igor B. Buchwalow, doctor of biological sciences, professor, Institute of Hematopathology, Hamburg, Germany
    Markus Tiemann, MD, professor, director of the Institute of Hematopathology, Hamburg, Germany

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