Clinical observation of a patient with primary hypoparathyroidism, uncontrolled hypocalcemia and heart failure


DOI: https://dx.doi.org/10.18565/therapy.2023.6.90-97

Katushkina Yu.A., Tatarintseva Z.G., Kosmacheva E.D., Petrik G.G.

1) Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky, Krasnodar; 2) Kuban State Medical University of the Ministry of Healthcare of Russia, Krasnodar
Abstract. Hypocalcemia and associated symptoms are common manifestations of postoperative hypoparathyroidism clinical picture. Meanwhile, there are not so many patients with hypocalcemia occurring due to primary hypoparathyroidism, manifested by heart failure (HF). Current article describes a clinical case of a 45-year-old female patient with primary hypoparathyroidism and uncontrolled hypocalcemia, in whom acute HF was developed, and was accompanied by a significant decrease in the left ventricular ejection fraction and heart cavities dilatation. After normalization of the calcium level in the blood serum, the clinical symptoms of HF regressed, cardiac function normalized. That rare case has shown the key role of calcium in maintaining cardiac function in such kind of patients, as well as the critical importance of abolition the reversible causes of HF.

Literature


1. Chou C.T., Siegel B., Mehta D. Stridor and apnea as the initial presentation of primary hypoparathyroidism. Int J Pediatr Otorhinolaryngol. 2016; 80: 30–32. https://dx.doi.org/10.1016/j.ijporl.2015.11.023.


2. de Oliveira Martins Duarte J., Pestana Pereira P.M.L., Sobral A.S.G. et al A rare and reversible case of heart failure: Hypocalcemia due to hypoparathyroidism. Clin Case Rep. 2019; 7(10): 1932–34. https://dx.doi.org/10.1002/ccr3.2397.


3. Parepa I., Mazilu L., Suceveanu A. et al. Hypocalcemic cardiomyopathy: A rare heart failure etiology in adult. Acta Endocrinol (Buchar). 2019; 5(1): 107–12. https://dx.doi.org/10.4183/aeb.2019.107.


4. Kalinowski L., Dobrucki L.W., Malinski T. Nitric oxide as a second messenger in parathyroid hormone-related protein signaling.J Endocrinol. 2001; 170(2): 433–40. https://dx.doi.org/10.1677/joe.0.1700433.


5. Bansal B., Bansal M., Bajpai P. et al. Hypocalcemic cardiomyopathy: Different mechanisms in adult and pediatric cases. J Clin Endocrinol Metab. 2014; 99(8): 2627–32. https://dx.doi.org/10.1210/jc.2013-3352.


6. Shoback D.M., Bilezikian J.P., Costa A.G. et al. Presentation of hypoparathyroidism: Etiologies and clinical features. J Clin Endocrinol Metab. 2016; 101(6): 2300–12. https://dx.doi.org/10.1210/jc.2015-3909.


7. Kim S.H., Rhee Y., Kim Y.M. et al Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study. PLoS One. 2020; 15(5): e0232842. https://dx.doi.org/10.1371/journal.pone.0232842.


8. Gosmanova E.O., Chen K., Ketteler M. et al. Risk of cardiovascular conditions in patients with chronic hypoparathyroidism: A retrospective cohort study. Adv Ther. 2021; 38(8): 4246–57. https://dx.doi.org/10.1007/s12325-021-01787-7.


9. Solzbach U., Kitterer H.R., Haas H. Reversible congestive heart failure in severe hypocalcemia. Herz. 2010; 35(7): 507–10.https://dx.doi.org/10.1007/s00059-010-3374-7.


About the Autors


Yulia A. Katushkina, endocrinologist at the Department of endocrinology, Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky, assistant at the Department of therapy No. 1 of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia. Address: 350901, Krasnodar, 140 Rossiyskaya Str.
E-mail: ukadoc@gmail.com
ORCID: https://orcid.org/0009-0009-7334-9928
Zoya G. Tatarintseva, head of the Department of cardiology, Scientific research institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky. Address: 350901, Krasnodar, 140 Rossiyskaya Str.
E-mail: z.tatarintseva@list.ru
ORCID: https://orcid.org/0000-0002-3868-8061
Elena D. Kosmacheva, MD, professor, head of the Department of therapy No. 1 of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia, deputy chief physician for the medical part of Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky. Address: 350901, Krasnodar, 140 Rossiyskaya Str.
E-mail: kosmachova_h@mail.ru
ORCID: https://orcid.org/0000-0001-5690-2482
Galina G. Petrik, MD, professor of the Department of therapy No. 1 of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia, endocrinologist at Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky. Address: 350901, Krasnodar, 140 Rossiyskaya Str.
E-mail: pgg@mail.ru
ORCID: https://orcid.org/0000-0003-4145-5602


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