Русский
Estimation of the risk of cardiovascular events and adverse outcomes in patients with peripheral atherosclerosis
DOI: https://dx.doi.org/10.18565/therapy.2024.1.21-29
Kobzeva N.D., Demidova A.A., Shlyk S.V., Martynov A.I., Shlyk I.F.
1) Rostov State Medical University of the Ministry of Healthcare of Russia, Rostov-on-Don; 2) Russian University of Medicine of the Ministry of Healthcare of Russia, Moscow
The aim: to develop a calculator for assessing the risk of cardiovascular events and adverse outcomes in patients with peripheral atherosclerosis during a three-year prospective observation, including data based on clinical and instrumental characteristics of endothelial function.
Material and methods. The study included 519 patients with atherosclerotic lesions of various vascular territories. The patients underwent a complex of laboratory tests and a number of instrumental tests, including (if indicated) coronary angiography, angiography of the renal, brachiocephalic and lower extremities arteries. During a prospective observation (36 months), the long-term prognosis of that group of individuals was assessed.
Results. Maximal discriminant significance according to the F-criterion when dividing patients depending on the risk of cardiovascular events and adverse outcomes developing had such indexes as the presence of hemodynamically significant peripheral atherosclerosis, value of the atherogenic index, value of glycated hemoglobin, gender of patients, age, biological vascular age and augmentation index value.
Conclusion. The developed calculator for assessing the risk of cardiovascular events and adverse outcomes developing allows us to highly accurately assess the probability of unfavorable long-term prognosis development in patients with peripheral atherosclerosis.
Literature
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About the Autors
Natalia D. Kobzeva, MD, PhD (Medicine), associate professor of the Department of therapy with a course of outpatient therapy, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: kobzeva.nataliya1@gmail.com
ORCID: https://orcid.org/0000-0002-3390-2452
Alexandra A. Demidova, MD, Dr. Sci. (Medicine), head of the Department of medical physics, mathematics and information technologies, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: alald@inbox.ru
ORCID: https://orcid.org/0000-0003-3545-9359
Sergey V. Shlyk, MD, Dr. Sci. (Medicine), professor, head of the Department of therapy with a course of outpatient therapy, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
ORCID: https://orcid.org/0000-0003-3070-8424
Anatoly I. Martynov, MD, Dr. Sci. (Medicine), professor, academician of RAS, professor of the Department of hospital therapy No. 1, Russian University of Medicine of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya St.
ORCID: https://orcid.org/0000-0002-0783-488X
Irina F. Shlyk, MD, Dr. Sci. (Medicine), professor of the Department of cardiology, rheumatology and functional diagnostics, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: sushkinaif@mail.ru
ORCID: https://orcid.org/000-0003-2193-7372
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