Linear IgA-dependent bullous dermatosis as a rare type of vancomycin therapy complication: A clinical case


DOI: https://dx.doi.org/10.18565/therapy.2024.2.72-76

Safronenko A.V., Gantsgorn E.V., Polyakova V.I., Gubin E.V., Rashkova E.V., Tuganov I.V.

Rostov State Medical University of the Ministry of Healthcare of Russia, Rostov-on-Don
Abstract. Any antibacterial pharmacotherapy is characterized by a certain profile of efficacy and safety. At the same time, some antibiotics, and vancomycin in particular, have a high degree of toxicity, and therefore their use is associated with a high risk of developing various adverse reactions. This, in turn, requires extremely strict adherence to the principles of rational antibiotic therapy, clear indications for prescribing the drug, and a careful assessment of the dynamics of the patient’s clinical status. The aim of the article is to describe a clinical case of the development of linear IgA-dependent bullous dermatosis while taking vancomycin in a patient from the “vulnerable” group. Improving doctors’ competence concerning antibacterial therapy complications, including rare ones, in our opinion, will make it possible to timely adjust the tactics of managing “difficult” patients in order to increase its safety.
Keywords: linear IgA-dependent bullous dermatosis, adverse drug reactions, vancomycin, antibacterial therapy
Read entire article

Literature

1. The selection and use of essential medicines 2023. Web Annex A. World Health Organization: Model list of essential medicines. 23rd list (2023). URL: https://iris.who.int/bitstream/handle/10665/371090/WHO-MHP-HPS-EML-2023.02-eng.pdf?sequence=1 (date of access – 26.02.2024).


2. Государственный реестр лекарственных средств Минздрава России. Инструкции к лекарственным препаратам с МНН ванкомицин. Доступ: https://grls.rosminzdrav.ru/GRLS.aspx?RegNumber=&MnnR=ванкомицин&lf=&TradeNmR=&OwnerName=&MnfOrg=&MnfOrgCountry=&isfs=0&regtype=1%2c6&pageSize=10&order=Registered&orderType=desc&pageNum=1 (дата обращения – 26.02.2024). (State register of medicines of the Ministry of Healthcare of Russia. Instructions for medicinal products with the INN vancomycin. URL: https://grls.rosminzdrav.ru/GRLS.aspx?RegNumber=&MnnR=ванкомицин&lf=&TradeNmR=&OwnerName=&MnfOrg=&MnfOrgCountry=&isfs=0&regtype=1%2c6&pageSize=10&order=Registered&orderType=desc&pageNum=1 (date of access – 26.02.2024) (In Russ.)).


3. Катина М.А., Тихоновская И.В. Субэпидермальные буллезные дерматозы. Часть I. Герпетиформный дерматит Дюринга, линейный IgA-зависимый буллезный дерматоз. Вестник Витебского государственного медицинского университета. 2019; 18(2): 7–15. (Katina M.A., Tikhonovskaya I.V. Subepidermal bullous dermatoses. Part I. Dermatitis herpetiformis and linear IgA dependent bullous dermatosis. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta = Bulletin of Vitebsk State Medical University. 2019; 18(2): 7–15 (In Russ.)).


https://doi.org/10.22263/2312-4156.2019.2.7. EDN: CBZZQF.


4. Знаменская Л.Ф., Чикин В.В., Нефедова М.А. Линеарный IgA-зависимый буллезный дерматоз. Вестник дерматологии и венерологии. 2018; 94(6): 42–51. (Znamenskaya L.F., Chikin V.V., Nefedova M.A. Linear IgA-dependent bullous dermatosis. Vestnik dermatologii i venerologii = Bulletin of Dermatology and Venereology. 2018; 94(6): 42–51 (In Russ.)).


https://doi.org/10.25208/0042-4609-2018-94-6-42-51. EDN: AEFVFN.


5. Yamagami J., Nakamura Y., Nagao K. et al. Vancomycin mediates IgA autoreactivity in drug-induced linear IgA bullous dermatosis. J Invest Dermatol. 2018; 138(7): 1473–80.


https://doi.org/10.1016/j.jid.2017.12.035. PMID: 29410066. PMCID: PMC8054301.


About the Autors

Andrey V. Safronenko, MD, Dr. Sci. (Medicine), associate professor, head of the Department of Pharmacology and Clinical Pharmacology, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: andrejsaf@mail.ru
ORCID: https://orcid.org/0000-0003-4625-6186
Elena V. Gantsgorn, MD, PhD (Medicine), associate professor, associate professor of the Department of Pharmacology and Clinical Pharmacology, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: gantsgorn@inbox.ru
ORCID: https://orcid.org/0000-0003-0627-8372
Victoriya I. Polyakova, student of Pediatric Faculty, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: polyakowa.vi@yandex.ru
ORCID: https://orcid.org/0000-0002-8886-8984
Evgeniy V. Gubin, student of Faculty of General Medicine, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: dr.gubin201@ya.ru
ORCID: https://orcid.org/0009-0009-3584-9147
Ekaterina V. Rashkova, student of Faculty of General Medicine, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: ekaterina.raschkova2002@gmail.com
ORCID: https://orcid.org/0009-0003-5619-5484
Iriston V. Tuganov, student of Pediatric Faculty, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane.
E-mail: anhel.kallen@mail.ru
ORCID: https://orcid.org/0009-0006-3325-3276


Similar Articles

Back to Content

Бионика Медиа