Severe osteoporosis against primary ovarian failure in triplet sisters


DOI: https://dx.doi.org/10.18565/therapy.2024.8.125-131

Dora S.V., Khalimov Yu.Sh., Lisker A.V., Shvets Z.V., Volkova A.R., Ostroukhova E.N., Mamedova N.A., Kolyabina A.B.

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia
Abstract. During menopause period, the risk of osteoporosis and pathological fractures increases, especially with its immature or early onset. Both heredity and possible prenatal developmental disorders play a significant role in the development of these conditions, especially in children born from multiple pregnancies. This emphasizes the necessity for special attention to females from the risk groups for their timely referral to specialized professionals, prescription of treatment for osteoporosis and consideration of the possibility of using menopausal hormone therapy. The article describes clinical cases of severe osteoporosis that developed in triplet sisters in connection with immature or early menopause. The interest of the presented observations could be explained by fact of the lack of treatment and referral to an endocrinologist for patients with multiple pathological fractures in their anamnesis, which indicates insufficient awareness of these diseases among doctors of other specialties.
Keywords: immature menopause, primary ovarian failure, early menopause, osteoporosis
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About the Autors

Svetlana V. Dora, MD, Dr. Sci. (Medicine), professor of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: doras2001@mail.ru
ORCID: https://orcid.org/0000-0002-8249-6075. eLibrary SPIN: 9845-0065
Yuri Sh. Khalimov, MD, Dr. Sci. (Medicine), professor, head of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: yushkha@gmail.com
ORCID: https://orcid.org/0000-0002-7755-7275. eLibrary SPIN: 7315-6746
Anna V. Lisker, MD, PhD (Medicine), head of the Department of endocrinology, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: a.lisker@mail.ru
ORCID: https://orcid.org/0000-0003-4295-1202. eLibrary SPIN: 3688-1505
Zlata V. Shvets, clinical resident in the specialty “endocrinology” of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: shvetszlata31@gmail.com
ORCID: https://orcid.org/0009-0007-9218-8133
Anna R. Volkova, MD, Dr. Sci. (Medicine), professor of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: volkovaa@mail.ru
ORCID: https://orcid.org/0000-0002-5189-9365. eLibrary SPIN: 4007-1288
Elena N. Ostroukhova, MD, PhD (Medicine), associate professor of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: elenikos9@gmail.com
ORCID: https://orcid.org/0000-0002-6542-7959. eLibrary SPIN: 4103-7025
Nargiz A. Mamedova, MD, physician at the Endocrinology Department, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: nsz90@mail.ru
ORCID: https://orcid.org/0009-0002-2709-3641
Alexandra B. Kolyabina, student of the Faculty of general medicine, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: kolyabinas@yandex.ru
ORCID: https://orcid.org/0009-0003-3136-3509


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