Фармакотерапия сухого кашля: что нужно знать терапевту?

1. Будневский А.В., Авдеев С.Н., Овсянников Е.С., Фейгельман С.Н., Чопоров О.Н., Максимов А.В., Перцев А.В. Спектральный анализ звуков кашля у больных COVID-19. Пульмонология. 2022;32(6):834–841. (Budnevsky AV, Avdeev SN, Ovsyannikov ES, Feygelman SN, Choporov ON, Maximov AV, Pertsev AV. Spectral analysis of cough sounds of patients with COVID-19. Pul'monologiya = Pulmonology. 2022;32(6):834–841 (In Russ.))

EDN: LJKOGO. https://doi.org/10.18093/0869-0189-2022-32-6-834-841

2. Климова Е.А., Самошкина Е.С. Сухой кашель. Инфекционные болезни: Новости. Мнения. Обучение. Журнал имени академика Н.Д. Ющука. 2013;2(3):39–44. (Klimova EA, Samoshkina ES. Dry cough. Infektsionnyye bolezni: Novosti. Mneniya. Obucheniye Zhurnal imeni akademika N.D. Yushchuka = Infectious Diseases: News. Opinions. Training. Journal named after academician N.D. Yushchuk. 2013;2(3):39–44 (In Russ.)). EDN: SFLEJR.

3. Joo YH, Kim HJ, Jeon YJ, Kim SW. Postnasal drip syndrome: A new definition and successful oral gargling treatment. Am J Otolaryngol. 2025;46(4):104617.

PMID: 40339213. https://doi.org/10.1016/j.amjoto.2025.104617

4. Зайцев А.А., Оковитый С.В., Мирошниченко Н.А., Крюков Е.В. Кашель. Методические рекомендации для врачей. М.: ФГБУ «Главный военный клинический госпиталь имени академика Н.Н. Бурденко» Министерства обороны Российской Федерации. 2021; 84 с. (Zaitsev AA, Okovityi SV, Miroshnichenko NA, Kryukov EV. Cough. Methodological recommendations for doctors. Moscow: Main Military Clinical Hospital named after academician N.N. Burdenko of the Ministry of Defence of the Russian Federation. 2021; 84 pp. (In Russ.)).

EDN: ISFFXZ. ISBN: 978-5-6045500-5-2

5. Wang N, Zhang Q, Wei JF. Cough syncope: A familiar stranger. Kaohsiung J Med Sci. 2024;40(7):685–86.

PMID: 38761411. PMCID: PMC11895576. https://doi.org/10.1002/kjm2.12830

6. O’Doherty DS. Tussive syncope and its relation to epilepsy. Neurology. 1953;3(1):16–21.

PMID: 13013494. https://doi.org/10.1212/wnl.3.1.16

7. Dickinson O, Akdemir B, Puppala VK, Krishnan B, Detloff BLS, Sakaguchi S et al. Blunted chronotropic response to hypotension in cough syncope. JACC Clin Electrophysiol. 2016;2(7):818–24.

PMID: 29759766. https://doi.org/10.1016/j.jacep.2016.02.017

8. Dicpinigaitis PV, Lim L, Farmakidis C. Cough syncope. Respir Med. 2014;108(2):244–51.

PMID: 24238768. https://doi.org/10.1016/j.rmed.2013.10.020

9. Будневский А.В., Авдеев С.Н., Овсянников Е.С., Фейгельман С.Н. Современный взгляд на патофизиологию кашля. Туберкулез и болезни легких. 2024;102(6):118–126. (Budnevskiy AV, Avdeev SN, Ovsyannikov ES, Feygelman SN. A modern view of cough pathophysiology. Tuberkulez i bolezni legkikh = Tuberculosis and Lung Diseases. 2024;102(6):118–126 (In Russ.)).

http://doi.org/10.58838/2075-1230-2024-102-6-118-126

10. Аполлонова А.Д. Курение как социально-экономическая проблема в России и Китае. Историческая социология и современное социальное развитие в России и Китае: Сборник статей XVIII российско-китайской социологической конференции, Санкт-Петербург, 13–14 мая 2022 г. Санкт-Петербург: Центр научно-производственных технологий «Астерион». 2022; с. 278–79. (Apollonova AD. Smoking as a socio-economic problem in Russia and China. Historical Sociology and Modern Social Development in Russia and China: Collection of Articles of the XVIII Russian-Chinese Sociological Conference, St. Petersburg, May 13–14, 2022. Saint Petersburg: Asterion Research and Production Technology Center.2022; pp. 278–279 (In Russ.)).

11. Kotz D, Batra A, Kastaun S. Smoking cessation attempts and common strategies employed. Dtsch Arztebl Int. 2020;117(1–2):7–13.

PMID: 32008606. PMCID: PMC7008148. http://doi.org/10.3238/arztebl.2020.0007

12. Schmidt HD, Rupprecht LE, Addy NA. Neurobiological and neurophysiological mechanisms underlying nicotine seeking and smoking relapse. Mol Neuropsychiatry. 2019;4(4):169–89.

PMID: 30815453. PMCID: PMC6388439. http://doi.org/10.1159/000494799

13. Smith ML, Gotway MB, Crotty Alexander LE, Hariri LP. Vaping-related lung injury. Virchows Arch. 2021;478(1):81–88.

PMID: 33106908. PMCID: PMC7590536. http://doi.org/10.1007/s00428-020-02943-0

14. Harris KK, Zopey M, Friedman TC. Metabolic effects of smoking cessation. Nat Rev Endocrinol. 2016;12(5);299–308.

PMID: 26939981. PMCID: PMC5021526. http://doi.org/10.1038/nrendo.2016.32. Erratum in: Nat Rev Endocrinol. 2016;12(11):684. PMID: 26939981. PMCID: PMC5021526. http://doi.org/10.1038/nrendo.2016.171

15. Budnevsky AV, Ovsyannikov ES, Feigelman SN, Kitoyan AG, Budnevskaya SA. Effectiveness of peripheral antitussives in patients with dry postinfectious cough. Indian J Med Spec. 2025;16(1):29–34.

http://doi.org/10.4103/injms.injms_50_24

16. Будневский А.В., Овсянников Е.С., Фейгельман С.Н. Исследование эффективности Левопронта в лечении непродуктивного кашля. Практическая пульмонология. 2021;(2):65–74. (Budnevsky AV, Ovsyannikov ES, Feigelman SN. Investigation of the effectiveness of Levopront in the treatment of unproductive cough. Prakticheskaya pul’monologiya = Practical Pulmonology. 2021;(2):65–74 (In Russ.)).

EDN: VMAKUE. http://doi.org/10.24412/2409-6636-2021-12693

17. Инструкция по медицинскому применению лекарственного препарата Левопронт®. Государственный реестр лекарственных средств Минздрава России. Доступ: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=841da703-273d-4f59-8f71-e8a09672c9fb (дата обращения – 19.02.2026). (Instructions for medical use of the medicinal product Levopront®. The State Register of Medicines of the Ministry of Healthcare of Russia. URL: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=841da703-273d-4f59-8f71-e8a09672c9fb (date of access – 19.02.2026) (In Russ.))

18. Lavezzo A, Melillo G, Clavenna G, Omini C. Peripheral site of action of levodropropizine in experimentally-induced cough: Role of sensory neuropeptides. Pulm Pharmacol. 1992;5(2):143–47.

PMID: 1611233. http://doi.org/10.1016/0952-0600(92)90033-d

19. Оковитый С.В., Суханов Д.С., Зайцев А.А. Кашель при новой коронавирусной инфекции (COVID-19): рациональные подходы к фармакотерапии. Пульмонология. 2022; 32(2):232–238. (Okovityi SV, Sukhanov DS, Zaicev AA. Cough associated with the new coronavirus infection (COVID-19): Rational approaches to pharmacotherapy. Pul'monologiya = Pulmonology. 2022;32(2):232–238 (In Russ.)).

EDN: UJRDPD. http://doi.org/10.18093/0869-0189-2022-32-2-232-238

20. Инструкция по медицинскому применению лекарственного препарата Либексин®. Государственный реестр лекарственных средств Минздрава России. Доступ: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=feecc727-47ea-4cb9-a3a1-f348143c391c (дата обращения – 19.02.2026) (Instructions for medical use of the drug Libexin®. The State Register of Medicines of the Ministry of Healthcare of Russia. URL: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=feecc727-47ea-4cb9-a3a1-f348143c391c (date of access – 19.02.2026) (In Russ.))

21. Gardiner SJ, Chang AB, Marchant JM, Petsky HL. Codeine versus placebo for chronic cough in children. Cochrane Database Syst Rev. 2016;7(7):CD011914.

PMID: 27405706. PMCID: PMC6457872. http://doi.org/10.1002/14651858.CD011914.pub2

22. Lee SP, Lee SM, Lee BJ, Kang SY. Effectiveness and safety of codeine and levodropropizine in patients with chronic cough. J Korean Med Sci. 2022;37(36):e275.

PMID: 36123964. PMCID: PMC9485064. http://doi.org/10.3346/jkms.2022.37.e275

23. Rajput R, Al Harakeh K, Figueras G, Mahi A, Minhas M, Sobolevskaia D et al. Dextromethorphan as an opioid-sparing analgesic in postoperative pain. Clin Neuropharmacol. 2025;48(4):109–11.

PMID: 40198711. http://doi.org/10.1097/WNF.0000000000000638

24. Ashwin JV, Shahi MK, Singh A, Kumar ST. Efficacy and safety of dextromethorphan-bupropion combination (AXS-05) in the treatment of depression: A systematic review and network meta-analysis. Indian J Pharmacol. 2025;57(4):262–68.

PMID: 40686359. PMCID: PMC12370225. http://doi.org/10.4103/ijp.ijp_907_24

25. Инструкция по медицинскому применению лекарственного препарата Омнитус®. Государственный реестр лекарственных средств Минздрава России. Доступ: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=4837d56b-0e75-4347-a4c1-5af1ecc179b7 (дата обращения – 19.02.2026) (Instructions for medical use of the medicinal product Omnitus®. The State Register of Medicines of the Ministry of Healthcare of Russia. URL: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=4837d56b-0e75-4347-a4c1-5af1ecc179b7 (date of access – 19.02.2026) (In Russ.))

26. Cortijo J, Villagrasa V, Pons R, Berto L, Martí-Cabrera M, Martinez-Losa M et al. Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes. Br J Pharmacol. 1999;127(7):1641–51.

PMID: 10455321. PMCID: PMC1566148. http://doi.org/10.1038/sj.bjp.0702702

27. Инструкция по медицинскому применению лекарственного препарата Бронхолитин®. Государственный реестр лекарственных средств Минздрава России. Доступ: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=3f1066a2-42d1-46d7-a867-02b1cc631e16 (дата обращения – 19.02.2026) (Instructions for medical use of the drug Broncholitin®. The State Register of Medicines of the Ministry of Healthcare of Russia. URL: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=3f1066a2-42d1-46d7-a867-02b1cc631e16 (date of access – 02.19.2026) (In Russ.))

28. David A, Leith-Ross F, Vallance DK. Antitussive and other pharmacological properties of the diethylaminoethoxyethyl ester of alpha alpha-diethylphenylacetic acid, (oxeladin). J Pharm Pharmacol. 1957;9(7);446–58.

PMID: 13439531. http://doi.org/10.1111/j.2042-7158.1957.tb12297.x

29. Morice A, Kardos P. Comprehensive evidence-based review on European antitussives. BMJ Open Resp Res. 2016;3(1):e000137.

PMID: 27547407. PMCID: PMC4985807. http://doi.org/10.1136/bmjresp-2016-000137

30. Будневский А.В., Авдеев С.Н., Овсянников Е.С., Фейгельман С.Н. Комплексные эффекты лекарственного препарата Эладис в терапии инфекционного кашля. Респираторная медицина. 2025;1(3):72–78. (Budnevsky AV, Avdeev SN, Ovsyannikov ES, Feigelman SN. Complex effects of Eladis drug in the treatment of infectious cough. Respiratornaya meditsina = Journal of Respiratory Medicine. 2025;1(3):72–78 (In Russ.)).

EDN: YKMKTS. https://doi.org/10.17116/respmed2025103172

31. Leung SY, Niimi A, Williams AS, Nath P, Blanc FX, Dinh QT, Chung KF. Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig. Cough. 2007;3:10.

PMID: 18154688. PMCID: PMC2262090. http://doi.org/10.1186/1745-9974-3-10

32. Patel HJ, Birrell MA, Crispino N, Hele DJ, Venkatesan P, Barnes PJ et al. Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. Br J Pharmacol. 2003;140(2):261–68.

PMID: 12970104. PMCID: PMC1574031. http://doi.org/10.1038/sj.bjp.0705435

33. McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J et al.; COUGH-1 and COUGH- 2 Investigators. Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): Results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials. Lancet. 2022;399(10328):909–23.

PMID: 35248186. http://doi.org/10.1016/S0140-6736(21)02348-5

34. Smith J, Allman D, Badri H, Miller R, Morris J, Satia I, Wood A, K Trower M. The neurokinin-1 receptor antagonist orvepitant is a novel antitussive therapy for chronic refractory cough: Results from a phase 2 pilot study (VOLCANO-1). Chest. 2020;157(1):111–18.

PMID: 31421110. http://doi.org/10.1016/j.chest.2019.08.001