Arterial stiffness and comorbidity pathology


DOI: https://dx.doi.org/10.18565/therapy.2020.2.123-130

Maychuk E.Yu., Voevodina I.V., Vyzhigin D.A.

A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia
Cardiovascular diseases (CVD) remain the most significant cause of death worldwide. The identification of CVD predictors is the opportunity to prevent death. Simple non-invasive methods being able to assess the state of health before the manifestation of CVD symptoms are most relevant. CVD are associated with structural changes in the vessel wall. The formation of arterial stiffness is a complex biomechanical process, which is primarily affected by the functional state of cardio-vascular system (CVS) and other factors. In patients with CVD the prevalence of comorbidity is high and it affects arterial stiffness. The review is based on published trials, illustrating that changes in arterial stiffness may be influenced by systemic inflammatory diseases. The presented clinical data, the results of pulse wave velocity measurements indicate the effect of systemic inflammatory processes on arterial stiffness. Independent cardiovascular risk factors exacerbate vascular damage in the presence of systemic inflammation. Changes in arterial stiffness progress earlier than symptoms of CVD appear. It is recommended that patients with manifestation of systemic inflammation diseases should measure arterial stiffness in order to identify early signs of CVD and prevent cardiovascular events.
Keywords: pulse wave velocity, cardiovascular diseases, arterial stiffness, systemic diseases, inflammation
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About the Autors

Elena Yu. Maychuk, MD, professor, professor of the Department of hospital therapy No 1 of A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. Tel.: +7 (916)736-93-49. E-mail: Emaichuk@yandex.ru
Irina V. Voevodina, MD, associate professor, professor of the Department of hospital therapy No 1 of A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. Tel.: +7 (916) 475-90-28. E-mail: Voevodina-1960@mail.ru
Dmitry A. Vyzhigin, a first year resident of the Department of hospital therapy No 1 of A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. Tel.: +7 (926) 680-87-62. E-mail: Dr.vyzhigin@gmail.com


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