Therapy » General patterns and regional features of epidemiology and the course of ulcerative colitis in the Rostov region

General patterns and regional features of epidemiology and the course of ulcerative colitis in the Rostov region

DOI: https://dx.doi.org/10.18565/therapy.2021.7.88-94

Tkachev A.V., Belovolova R.A., Mkrtchyan L.S., Mazovka K.E.
Rostov State Medical University of the Ministry of Healthcare of Russia, Rostov-on-Don

Aim. The increase in the incidence of ulcerative colitis (UC) increases the need for a deeper study of the peculiarities of this pathology, particular, in the Rostov region, such as the clinical and morphological characteristics of UC, the possibility of remission on the background of various therapy regimens, recurrence of the disease and its complications.
Material and methods. A prospective study was performed. 70 patients with UC were included. Clinical and laboratory instrumental studies were carried out, and the effectiveness of various drug therapy regimens was analyzed.
Results. It has been established that UC in the Rostov region mainly affects people of working age, in 1/5 of patients a relapse of the disease occurs against the background of the absence of anti-relapse therapy. When evaluating laboratory data, an increase in CRP, ESR, anemic syndrome and leukocytosis is noted. The effectiveness of aminosalicylates therapy was 78%, prednisolone and azathioprine 78%, infliximab in combination with azathioprine 80%.
Conclusion. The study revealed the dissociation of clinical, morphological and histological remission of UC in the Rostov region, as well as the high efficiency of different therapeutic approaches in compliant UC patients.

Keywords: ulcerative colitis, azathioprine, mesalazine, infliximab

Read entire article

About the Autors

Alexander V. Tkachev, MD, professor, head of the Department of propedeutics of internal medicine, Rostov State Medical University of the Ministry of Healthcare of Russia, chief freelance gastroenterologist of the Ministry of Healthcare of the Rostov Region. Address: 344022, Rostov-on-Don, 119/80 Suvorova Str. E-mail: tkachev@aaanet.ru. ORCID: 0000-0002-5554-7084
Lilit S. Mkrtchyan, associate professor of the Department of propedeutics of internal medicine, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 119/80 Suvorova Str. E-mail: lilit268@rambler.ru. ORCID: 0000-0002-1820-4488
Karina E. Mazovka, PhD, associate professor of the Department of propedeutics of internal medicine, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 119/80 Suvorova Str. E-mail: k.mazovka@gmail.com. ORCID: 0000-0002-0436-6208
Rozalia A. Belovolova, MD, professor of the Department of propedeutics of internal medicine, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 119/80 Suvorova Str.

Back to Content