Preoperative anemia: impact on surgical outcomes and treatment options


DOI: https://dx.doi.org/10.18565/therapy.2022.6.127-132

Laryushkina E.D., Vasilchenko M.I., Zhuravleva M.V., Kameneva T.R., Khovasova N.O., Teterin A.V.

1) M.P. Konchalovsky City Clinical Hospital of the Moscow Healthcare Department; 2) I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenovsky University); 3) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow
Abstract. Preoperative anemia is an independent factor influencing the development of adverse outcomes in patients in the postoperative period. A decrease in hemoglobin level by 10 g/l increases the perioperative risk by 40%. However, despite the proven facts of the negative effects of anemia, the decrease in hemoglobin, which does not require blood transfusions, is still ignored. Currently, the algorithm of actions and routing of patients in the detection of anemia before planned surgical intervention is not clearly defined. Various medical communities propose to develop local protocols, depending on the surgical interventions carried out in a particular medical organization, as well as the timing and possibility of postponing the operation. The results of several studies confirm that the optimal hemoglobin level is 130 g/l in both men and women. Depending on the type of preoperative anemia, various therapeutic options can be used.

Literature


1. Segon Y.S., Dunbar S., Slawski B. Perioperative anemia: Clinical practice update. Hosp Pract (1995). 2021; 49(3): 133–140.https://dx.doi.org/10.1080/21548331.2021.1889214.


2. Shander A., Goodnough L.T., Javidroozi M. et al. Iron deficiency anemia – bridging the knowledge and practice gap. Transfus Med Rev. 2014; 28(3): 156–66. https://dx.doi.org/10.1016/j.tmrv.2014.05.001.


3. Shander A., Knight K., Thurer R. et al. Prevalence and outcomes of anemia in surgery: a systematic review of the literature. Am J Med. 2004; 116 Suppl 7A: 58S–69S. https://dx.doi.org/10.1016/j.amjmed.2003.12.013.


4. Gomez-Ramirez S., Bisbe E., Shander A. et al. Management of perioperative iron deficiency anemia. Acta Haematol. 2019; 142(1): 21–29. https://dx.doi.org/10.1159/000496965.


5. Munoz M., Laso-Morales M.J., Gomez–Ramirez S. et al. Pre–operative haemoglobin levels and iron status in a large multicentre cohort of patients undergoing major elective surgery. Anaesthesia. 2017; 72(7): 826–34. https://dx.doi.org/10.1111/anae.13840.


6. Диагностика и лечение периоперационной анемии и дефицита железа у хирургических пациентов: методическое руководство. Коллектив авторов; ред. акад. РАН В.Н. Серов. Чебоксары: ИД «Среда». 2021; 60 с. [Diagnosis and treatment of perioperative anemia and iron deficiency in surgical patients: a methodological guide. Team of authors; ed. by acad. RAS V.N. Serov. Cheboksary: Publishing house «Sreda». 2021; 60 pp. (In Russ.)]. ISBN: 978–5–907411–35–7.


7. Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015; 372(19): 1832–43. https://dx.doi.org/10.1056/NEJMra1401038.


8. Fowler A.J., Ahmad T., Phull M.K. et al. Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg. 2015; 102(11): 1314–24. https://dx.doi.org/10.1002/bjs.9861.


9. Halm E.A., Wang J.J., Boockvar K. et al. The effect of perioperative anemia on clinical and functional outcomes in patients with hip fracture. J Orthop Trauma. 2004; 18(6): 369–74. https://dx.doi.org/10.1097/00005131–200407000–00007.


10. Musallam K.M., Tamim H.M., Richards T. et al. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: A retrospective cohort study. Lancet. 2011; 378(9800): 1396–407. https://dx.doi.org/10.1016/S0140–6736(11)61381–0.


11. Dunne J.R., Malone D., Tracy J.K. et al. Perioperative anemia: An independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res. 2002; 102(2): 237–44. https://dx.doi.org/10.1006/jsre.2001.6330.


12. Carson J.L., Spence R.K., Poses R.M. et al. Severity of anaemia and operative mortality and morbidity. Lancet. 1988; 331(8588): 727–29. https://dx.doi.org/10.1016/s0140–6736(88)91536–x.


13. Farrell A.M., Brazier M. Consent for blood transfusion. BMJ. 2010; 341:c4336. https://dx.doi.org/10.1136/bmj.c4336.


14. World Health Organization. Blood transfusion safety. URL: https://www.who.int/bloodsafety/resolutions/en/ (date of access – 01.08.2022).


15. Goel R., Shi P.A. Best practice recommendations: Patient blood management. In: Transfusion medicine and hemostasis. 3rd ed. Philadelphia, PA: Elsevier. 2019; pp. 371–78. ISBN: 9780128137260, 9780128137277.


16. Gombotz H., Rehak P.H., Shander A., Hofmann A. Blood use in elective surgery: the Austrian benchmark study. Transfusion. 2007; 47(8): 1468–80. https://dx.doi.org/10.1111/j.1537–2995.2007.01286.x.


17. Mukhtar S.A., Leahy M.F., Koay K. et al. Effectiveness of a patient blood management data system in monitoring blood use in Western Australia. Anaesth Intensive Care. 2013; 41(2): 207–15. https://dx.doi.org/10.1177/0310057X1304100210.


18. Meybohm P., Herrmann E., Steinbicker A.U. et al; PBM–study Collaborators. Patient blood management is associated with a substantial reduction of red blood cell utilization and safe for patient’s outcome: a prospective, multicenter cohort study with a noninferiority design. Ann Surg. 2016; 264(2): 203–11. https://dx.doi.org/10.1097/SLA.0000000000001747.


19. NICE. Blood transfusion: NICE guidelines NG24. URL: https://www.nice.org.uk/guidance/ng24 (date of access – 01.08.2022).


20. CPOC. Addressing preoperative anaemia. URL: https://www.cpoc.org.uk/guidelines–resources–guidelines–resources/addressing–preoperative–anaemia (date of access – 01.08.2022).


21. Jans O., Jorgensen C., Kehlet H., Johansson P.I.; Lundbeck Foundation Centre for Fast–track Hip and Knee Replacement Collaborative Group. Role of preoperative anemia for risk of transfusion and postoperative morbidity in fast–track hip and knee arthroplasty. Transfusion. 2014; 54(3): 717–26. https://dx.doi.org/10.1111/trf.12332.


22. Spahn D.R., Zacharowski K. Non-treatment of preoperative anaemia is substandard clinical practice. Br J Anaesth. 2015; 115(1): 1–3. https://dx.doi.org/10.1093/bja/aev099.


23. World Health Organization. Anaemia. URL: https://www.who.int/health–topics/anaemia#tab=tab_1 (date of access – 01.08.2022).


24. Rosencher N., Kerkkamp H.E., Macheras G. et al. Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) study: Blood management in elective knee and hip arthroplasty in Europe. Transfusion. 2003; 43(4): 459–69.https://dx.doi.org/10.1046/j.1537–2995.2003.00348.x.


25. Munoz M., Gomez-Ramirez S., Kozek-Langeneker S. et al. «Fit to fly»: Overcoming barriers to preoperative haemoglobin optimization in surgical patients. Br J Anaesth. 2015; 115(1): 15–24. https://dx.doi.org/10.1093/bja/aev165.


26. Hong F.S., Sieradzki N., Pollock C. et al. Prevalence and causes of preoperative anaemia in elective major surgery patients. Intern Med J. 2017; 47(12): 1400–4. https://dx.doi.org/10.1111/imj.13613.


27. Deloughery T.G. Iron deficiency anemia. Med Clin North Am. 2017; 101(2): 319–32. https://dx.doi.org/10.1016/j.mcna.2016.09.004.


28. Baart A.M., Balvers M.G.J., Hopman M.T.E. et al. Reticulocyte hemoglobin content in a large sample of the general Dutch population and its relation to conventional iron status parameters. Clin Chim Acta. 2018; 483: 20–24. https://dx.doi.org/10.1016/j.cca.2018.04.018.


29. Hoffbrand A. Megaloblastic Anemias. In: Jameson J., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Loscalzo J. eds. Harrison’s principles of internal medicine, 20e. McGraw Hill; 2018.URL: https://accessmedicine.mhmedical.com/content.aspx?bookid=2129&sectionid=192017242 (date of access – 01.08.2022).


30. Государственный реестр лекарственных средств Минздрава России. Доступ: https://grls.rosminzdrav.ru/ (дата обращения – 01.08.2022). [State Register of Medicines of the Ministry of Healthcare of Russia.URL: https://grls.rosminzdrav.ru/ (date of access – 01.08.2022).


31. Jimenez K., Kulnigg-Dabsch S., Gasche C. Management of iron deficiency anemia. Gastroenterol Hepatol. 2015; 11(4): 241–50.


32. Stoffel N.U., Cercamondi C.I., Brittenham G. et al. Lancet Haematol. 2017; 4(11): e524–e533.https://dx.doi.org/10.1016/S2352–3026(17)30182–5.


33. Ganz T. Anemia of chronic disease. In: Kaushansky K., Lichtman M.A., Prchal J.T., Levi M.M., Press O.W., Burns L.J., Caligiuri M. eds. Williams hematology, 9e. McGraw Hill; 2015. URL: https://hemonc.mhmedical.com/content.aspx?bookid=1581&sectionid=94303965 (date of access – 01.08.2022).


34. Cho B.C., Serini J., Zorrilla-Vaca A. et al. Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta–analysis. Anesth Analg. 2019; 128(5): 981–92.https://dx.doi.org/10.1213/ANE.0000000000004005.


35. Green R., Datta Mitra A. Megaloblastic anemias: Nutritional and other causes. Med Clin North Am. 2017; 101(2): 297–317.https://dx.doi.org/10.1016/j.mcna.2016.09.013.


About the Autors


Elena D. Laryushkina, clinical pharmacologist at M.P. Konchalovsky City Clinical Hospital of the Moscow Healthcare Department. Address: 124489, Moscow, Zelenograd, 2/1 Kashtanovaya Alley. E–mail: edlaryushkina@gmail.com. ORCID: https://orcid.org/0000-0003-2968-8235
Mikhail I. Vasilchenko, Dr. med. habil., deputy chief physician for surgical care of M.P. Konchalovsky City Clinical Hospital of the Moscow Healthcare Department. Address: 124489, Moscow, Zelenograd, 2/1 Kashtanovaya Alley. E–mail: gkb–konchalovskogo@zdrav.mos.ru. ORCID: https://orcid.org/0000–0002–1916–4449
Marina V. Zhuravleva, Dr. med. habil., professor of the Department of clinical pharmacology and internal diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenovsky University). Address: 119435, Moscow, 6/1 Bol`shaya Pirogovskaya Str. E–mail: zhuravleva_m_v@staff.sechenov.ru.
ORCID: https://orcid.org/0000–0002–9198–8661
Tatiana R. Kameneva, PhD in Medicine, associate professor, clinical pharmacologist at M.P. Konchalovsky City Clinical Hospital of the Moscow Healthcare Department. Address: 124489, Moscow, Zelenograd, 2/1 Kashtanovaya Alley. E–mail: tkamenek@mail.ru. ORCID: https://orcid.org/0000–0003–3957–5015
Natalia O. Khovasova, PhD in Medicine, associate professor of the Department of aging-associated diseases of the Faculty of additional professional education, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, senior researcher at the Laboratory of diseases of the musculoskeletal system of Russian Gerontological Research and Clinical Center, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 129226, Moscow, 16 1st Leonova Str. E–mail: natashahov@mail.ru.
ORCID: https://orcid.org/0000–0002–3066–4866
Andrey V. Teterin, head of the Department of purulent surgery, M.P. Konchalovsky City Clinical Hospital of the Moscow Healthcare Department. Address: 124489, Moscow, Zelenograd, 2/1 Kashtanovaya Alley. E–mail: andr_teterin@mail.ru


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