Polymorphic variants of renin-angiotensin-aldosterone system genes in female patients with a history of arterial hypertension during pregnancy and their association with metabolic syndrome


DOI: https://dx.doi.org/10.18565/therapy.2024.2.41-48

Tarasova O.A., Chulkov V.S., Ektova N.A., Chulkov Vl.S.

1) South Ural State Medical University of the Ministry of Healthcare of Russia, Chelyabinsk; 2) Yaroslav the Wise Novgorod State University
Abstract. Genetic factors play an important role in the development of arterial hypertension (AH), and their determination at a young age could be potentially used in predicting associated cardiometabolic diseases.
The aim: to analyze the frequency of occurrence of polymorphic variants of renin-angiotensin-aldosterone system (RAAS) genes rs699, rs4762, rs5186, rs4340 in female patients with a history of AH during pregnancy and their association with metabolic syndrome (MS).
Material and methods. 66 female patients were included in the “case – control” study. They were divided into 2 groups: group 1 (“Cases”) – 33 females with a history of hypertension during pregnancy; group 2 (“Controls”) – 33 females without a history of hypertension during pregnancy. An examination was carried out, blood pressure and anthropometric parameters were measured, metabolic profile was assessed, and polymorphic variants of the RAAS genes rs699, rs4762, rs5186, rs4340 were determined.
Results. Female patients with a history of arterial hypertension during pregnancy were older, had higher values of body mass index, waist circumference, systolic and diastolic blood pressure, carbohydrate and lipid metabolism indexes; every third female in this group was diagnosed with MS. Regardless of age and body mass index, M/T gene genotype of the angiotensinogen rs4762 gene (ATG Thr174Met) was negatively associated with MS in females with a history of hypertension during pregnancy.
Conclusion. Obtained results may help in working out of predictive models of cardiometabolic diseases development in female patients with a history of hypertension during pregnancy, as well as become an important step towards identifying the expression of candidate genes involved in the development of multifactorial diseases.
Keywords: medical genetics, hypertensive disorders during pregnancy, renin-angiotensin-aldosterone system, angiotensinogen, metabolic syndrome, arterial hypertension
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About the Autors

Olesya A. Tarasova, MD, assistant at the Department of faculty therapy, South Ural State Medical University of the Ministry of Healthcare of Russia. Address: 454092, Chelyabinsk, 64 Vorovskogo St.
E-mail: Tarasova.o.a@bk.ru
ORCID: https://orcid.org/0000-0002-0965-2836
Vasily S. Chulkov, MD, Dr. Sci. (Medicine), professor of the Department of internal diseases, Yaroslav the Wise Novgorod State University. Address: 173003, Veliky Novgorod, 41 Bolshaya Sankt-Petersburgskaya St.
E-mail: vschulkov@rambler.ru
ORCID: https://orcid.org/0000-0002-0952-6856
Natalya A. Ektova, MD, PhD (Medicine), associate professor of the Department of faculty therapy, South Ural State Medical University of the Ministry of Healthcare of Russia. Address: 454092, Chelyabinsk, 64 Vorovskogo St.
E-mail: Ektnachel@mail.ru
ORCID: https://orcid.org/0000-0002-4416-0853
Vladislav S. Chulkov, MD, PhD (Medicine), associate professor of the Department of faculty therapy, South Ural State Medical University of the Ministry of Healthcare of Russia. Address: 454092, Chelyabinsk, 64 Vorovskogo St.
E-mail: vlad.chulkov.1989@mail.ru
ORCID: https://orcid.org/0000-0002-1948-8523


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