Asymptomatic hyperuricemia in young men, identified during check-up period: Prevalence and association with population diseases


DOI: https://dx.doi.org/10.18565/therapy.2024.4.74-81

Masterova M.M., Georginova O.A., Abdrakhimov D.A., Krasnova T.N.

1) M.V. Lomonosov Moscow State University; 2) Russian State Agrarian University – Moscow K.A. Timiryazev Agricultural Academy
Abstract. The worldwide prevalence of asymptomatic hyperuricemia (ASH) throughout the world is high and has a tendency to increase over the past few decades. Growth in serum uric acid (UA) levels can cause “silent” tissue damage and increase the risk of a number of diseases, such as arterial hypertension, obesity, metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, etc.
The aim: to study the correlation between asymptomatic increases in UA level and the level of biochemical markers of metabolic syndrome in the blood serum of apparently healthy young male individuals.
Material and methods. A cohort study of 575 deidentified young male patients (18–44 years old according to World health organization criteria) without comorbidities was performed. All participants were assessed for UA levels, serum creatinine, glomerular filtration rate (GFR), triglyceride concentrations, total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL), glucose, glycated hemoglobin (HbA1c), insulin, and also for height, weight, body mass index (BMI).
Results. ASH was identified in 243 male individuals (41% of participants). A weak positive correlation was established between the levels of uric acid and creatinine in the blood serum, positive correlation of the level of uric acid with the amount of triglycerides, total cholesterol, LDL, insulin, and BMI. No correlation was found between the level of UA in the blood serum and the level of glucose, GFR, HDL, and HbA1c.
Conclusion. Due to the high prevalence of ASH among young population, regular screening of serum UA levels is necessary. The results of the study indicate the need to study the cause-and-effect relationships of ASH development with obesity, disorders of lipid and carbohydrate metabolism, kidney function disorders in order to prevent the development and progression of chronic diseases.
Keywords: asymptomatic hyperuricemia, young age, triglycerides, insulin, uric acid, creatinine, body mass index, cholesterol
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About the Autors

Maria M. Masterova, clinical resident of the Department of internal medicine of the Faculty of fundamental medicine, M.V. Lomonosov Moscow State University. Address: 119991, Moscow, 27/1 Lomonosovsky Highway.
E-mail: mmmasterova@mail.ru
ORCID: https://orcid.org/0009-0005-0272-2597
Olga A. Georginova, MD, PhD (Medicine), associate professor of the Department of internal medicine of the Faculty of fundamental medicine, M.V. Lomonosov Moscow State University. Address: 119991, Moscow, 27/1 Lomonosovsky Highway.
E-mail: olga.georginova@gmail.com
ORCID: https://orcid.org/0000-0002-7542-8189
Daniil A. Abdrakhimov, MD, postgraduate student of the Department of tractors and automobiles, Russian State Agrarian University – Moscow K.A. Timiryazev Agricultural Academy. Address: 127550, Moscow, 7 Listvennicheskaya alleya St.
E-mail: dan-abdrakhimov@ya.ru
ORCID: https://orcid.org/0000-0003-2616-2887
Tatyana N. Krasnova, MD, PhD (Medicine), associate professor, head of the Department of internal diseases of the Faculty of fundamental medicine, M.V. Lomonosov Moscow State University. Address: 119991, Moscow, 27/1 Lomonosovsky Highway.
E-mail: krasnovamgu@yandex.ru
ORCID: https://orcid.org/0000-0001-6175-1076


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