Hypokalemia in a patient with heart failure and atrial fibrillation as a predictor of life-threatening arrhythmia


DOI: https://dx.doi.org/10.18565/therapy.2024.6.122-128

Tatarintseva Z.G., Katushkina Yu.A., Kosmacheva E.D., Babicheva O.V.

1) Professor S.V. Ochapovsky Research Institute – Regional Clinical Hospital No. 1 of the Ministry of Healthcare of Krasnodar territory, Krasnodar; 2) Kuban State Medical University of the Ministry of Healthcare of Russia, Krasnodar
Abstract. Atrial fibrillation (AF) is the most common arrhythmia in patients with heart failure (HF). Growing evidence indicates an interaction between hypokalemia and AF. The presented clinical case demonstrates one of the life-threatening complications of hypokalemia in a patient with HF and AF – development of ventricular fibrillation, which was successfully terminated by electropulse therapy and did not recur in the presence of antiarrhythmic therapy and hypokalemia correction. Low potassium level could be eliminated by titrating mineralocorticoid receptor antagonists. In addition, to increase K+ level in tissues, it is advisable to take drugs containing high doses of potassium and magnesium aspartate. This clinical example emphasizes the critical importance of adequate drug therapy to prevent life-threatening complications such as ventricular fibrillation.

Literature


1. Packer M., Anker S.D., Butler J. et al.; EMPEROR-Reduced Trial Investigators. Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med. 2020; 383(15): 1413–24.


https://doi.org/10.1056/NEJMoa2022190. PMID: 32865377.


2. McMurray J.J.V., Packer M., Desai A.S. et al.; PARADIGM-HF Investigators and Committees. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014; 371(11): 993–1004.


https://doi.org/10.1056/NEJMoa1409077. PMID: 25176015.


3. Reddy Y.N.V., Obokata M., Verbrugge F.H. et al. Atrial dysfunction in patients with heart failure with preserved ejection fraction and atrial fibrillation. J Am Coll Cardiol. 2020; 76(9): 1051–64.


https://doi.org/10.1016/j.jacc.2020.07.009. PMID: 32854840. PMCID: PMC7455760.


4. Wu Y., Kong X.-J., Ji Y.Y. et al. Serum electrolyte concentrations and risk of atrial fibrillation: An observational and mendelian randomization study. BMC Genomics. 2024; 25(1): 280.


https://doi.org/10.1186/s12864-024-10197-2. PMID: 38493091. PMCID: PMC10944597.


5. Fargaly H., Schultz R.J., Chung U.Y., Rossi N.F. Hypokalemia-induced life-threatening arrhythmia in a patient with congestive heart failure. Cureus. 2023; 15(2): e34971.


https://doi.org/10.7759/cureus.34971. PMID: 36938242. PMCID: PMC10019554.


6. Savarese G., Xu H., Trevisan M. et al. Incidence, predictors, and outcome associations of dyskalemia in heart failure with preserved, mid-range, and reduced ejection fraction. JACC Heart Fail. 2019; 7(1): 65–76.


https://doi.org/10.1016/j.jchf.2018.10.003. PMID: 30553905.


7. Ferreira J.P., Butler J., Rossignol P. et al. Abnormalities of potassium in heart failure: JACC state-of-the-art review. J Am Coll Cardiol. 2020; 75(22): 2836–50.


https://doi.org/10.1016/j.jacc.2020.04.021. PMID: 32498812.


8. Skogestad J., Aronsen J.M. Hypokalemia-induced arrhythmias and heart failure: New insights and implications for therapy. Front Physiol. 2018; 9: 1500.


https://doi.org/10.3389/fphys.2018.01500. PMID: 30464746. PMCID: PMC6234658.


9. Aronsen J.M., Skogestad J., Lewalle A. et al. Hypokalaemia induces Ca2+ overload and Ca2+ waves in ventricular myocytes by reducing Na+, K+-ATPase α2 activity. J Physiol. 2015; 593(6): 1509–21.


https://doi.org/10.1113/jphysiol.2014.279893. PMID: 25772299. PMCID: PMC4376427.


10. Wang X.-D., Wang Y., Liu J. et al. Prognosis of older adult patients suffering from atrial fibrillation and hypokalemia. Clin Interv Aging. 2023; 18: 1363–71.


https://doi.org/10.2147/CIA.S422801. PMID: 37609041. PMCID: PMC10441655.


11. Guzel T., Kıs M., Senoz O. The correlation between the left atrial volume index and atrial fibrillation development in heart failure with mildly reduced ejection fraction and long-term follow-up results. Acta Cardiol. 2022; 77(7): 647–54.


https://doi.org/10.1080/00015385.20222.2067674. PMID: 35466864.


12. Chung M.K., Refaat M., Shen W.-K. et al.; ACC Electrophysiology Section Leadership Council. Atrial fibrillation: JACC Council Perspectives. J Am Coll Cardiol. 2020; 75(14): 1689–713.


https://doi.org/10.1016/j.jacc.2020.02.025. PMID: 32273035.


13. Cunningham J.W., Mehra M.R. Hypokalemia in heart failure: A low or a high point? Eur J Prev Cardiol. 2021; 28(3): 313–15.


https://doi.org/10.1177/2047487320914745. PMID: 33611466.


14. Alvarez C.K., Cronin E., Baker W.L., Kluger J. Heart failure as a substrate and trigger for ventricular tachycardia. J Interv Card Electrophysiol. 2019; 56(3): 229–47.


https://doi.org/10.1007/s10840-019-00623-x. PMID: 31598875.


15. Государственный реестр лекарственных средств Минздрава России. Инструкции по медицинскому применению лекарственных препаратов с МНН калия аспарагинат + магния аспарагинат. Доступ: https://grls.rosminzdrav.ru/GRLS.aspx?RegNumber=&MnnR=Калия+аспарагинат%2bМагния+аспарагинат&lf=&TradeNmR=&OwnerName=&MnfOrg=&MnfOrgCountry=&isfs=0&regtype=1%2c6&pageSize=10&token=429c9023-dd79-4811-aa14-13d2e7ed8379&order=Registered&orderType=desc&pageNum=1 (дата обращения – 20.08.2024). (State Register of Medicines of the Ministry of Healthcare of Russia. Instructions for medical use of the medicinal products with INN potassium aspartate + magnesium aspartate. Registration certificate: ЛП-№(000178)-(РГ-RU). URL: https://grls.rosminzdrav.ru/GRLS.aspx?RegNumber=&MnnR=Калия+аспарагинат%2bМагния+аспарагинат&lf=&TradeNmR=&OwnerName=&MnfOrg=&MnfOrgCountry=&isfs=0&regtype=1%2c6&pageSize=10&token=429c9023-dd79-4811-aa14-13d2e7ed8379&order=Registered&orderType=desc&pageNum=1 (date of access – 20.08.2024) (In Russ.)).


About the Autors


Zoya G. Tatarintseva, MD, PhD (Medicine), head of the Cardiology Department of Professor S.V. Ochapovsky research institute – Regional Clinical Hospital No. 1 of the Ministry of Healthcare of Krasnodar territory, assistant at the Department of cardiac surgery and cardiology of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia. Address: 350086, Krasnodar, 167 1-go Maya St.
E-mail: z.tatarintseva@list.ru
ORCID: https://orcid.org/0000-0002-3868-8061
Elena D. Kosmacheva, MD, Dr. Sci. (Medicine), professor, head of the Department of therapy No. 1 of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia, deputy chief physician for medical affairs, S.V. Ochapovsky Research Institute – Regional Clinical Hospital No. 1 of the Ministry of Healthcare of Krasnodar territory. Address: 350063, Krasnodar, 4 Mitrofana Sedina St.
E-mail: kosmachova_h@mail.ru
ORCID: https://orcid.org/0000-0001-5690-2482
Yulia A. Katushkina, MD, endocrinologist at the Department of endocrinology, S.V. Ochapovsky Research Institute – Regional Clinical Hospital No. 1 of the Ministry of Healthcare of Krasnodar territory, assistant at the Department of therapy No. 1 of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia. Address: 350901, Krasnodar, 140 Rossiyskaya St.
E-mail: ukadoc@gmail.com
ORCID: https://orcid.org/0009-0009-7334-9928
Olga V. Babicheva, MD, PhD (Medicine), cardiologist at Professor S.V. Ochapovsky Research Institute – Regional clinical hospital No. 1 of the Ministry of Healthcare of Krasnodar territory, associate professor of the Department of cardiac surgery and cardiology of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia. Address: 350086, Krasnodar, 167 1-go Maya St.
E-mail: babolga@mail.ru
ORCID: https://orcid.org/0000-0003-3010-492Х


Similar Articles


Бионика Медиа