Clinical efficacy of the combination of indacaterol and glycopyrronium bromide in the treatment of chronic obstructive pulmonary disease at smoking cessation stage


DOI: https://dx.doi.org/10.18565/therapy.2024.6.170-176

Kupaev V.I., Osipov D.A.

Samara State Medical University of the Ministry of Healthcare of Russia
Abstract. Therapy of chronic obstructive pulmonary disease (COPD) begins with smoking cessation. An attempt to quit nicotine addiction becomes successful if patient receives adequate bronchodilator therapy.
The aim: to make a comparative analysis of the clinical efficacy of indacaterol and glycopyrronium bromide combination in COPD patients at the stage of smoking cessation.
Material and methods. 111 patients with a high degree of nicotine dependence and irreversible bronchoobstruction were involved in the study. All of them received bronchodilator therapy in accordance with clinical guidelines. The participants were divided into two groups: patients who quit smoking (group 1, n = 53) and patients who continued smoking (group 2, n = 58). In turn, each group was divided into two subgroups depending on the drug used – glycopyrronium bromide 50 mcg or a combination of indacaterol / glycopyrronium bromide (110/50 mcg). Changes in forced expiratory volume in 1 second (FEV1) and the dynamics of COPD assessment test were estimated.
Results. The study revealed an increase of FEV1 and a decrease of COPD assessment test value in both groups. In patients of the 1st group who quit smoking and received a combination of indacaterol and glycopyrronium bromide, the changes had obvious statistically significant differences from the comparison groups (p = 0.0001).
Conclusion. At the stage of smoking cessation in COPD treatment, a combination of indacaterol and glycopyrronium bromide (110/50 mcg) demonstrated high clinical efficacy, which should be recommended to all quitting smoking patients.
Keywords: long-acting muscarinic antagonists, long-acting β2-agonists, nicotine addiction, glycopyrronium bromide, indacaterol, chronic obstructive pulmonary disease
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About the Autors

Vitaly I. Kupaev, MD, Dr. Sci. (Medicine), professor, head of the Department of family medicine with a course in telemedicine technologies, Samara State Medical University of the Ministry of Healthcare of Russia. Address: 443099, Samara, 89 Chapaevskaya St.
E-mail: vk1964sam@rambler.ru
ORCID: https://orcid.org/0000-0003-2639-0003
Dmitry A. Osipov, MD, postgraduate student of the Department of family medicine with a course in telemedicine technologies, Samara State Medical University of the Ministry of Healthcare of Russia. Address: 443099, Samara, 89 Chapaevskaya St.
E-mail: dmitriylapka@gmail.com
ORCID: https://orcid.org/0000-0003-0847-7922


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