An intrapericardial mass with features of teratoma as a rare cause of acute coronary syndrome: a case report and 4-year follow-up
M.Z. Gasanov, A.V. Sokolovskaya, A.V. Gasanova, O.E. Kolomatskaya, V.S. Chulkov, V.R. Veber
ABSTRACT. The present clinical case demonstrates a rare variant of acute coronary syndrome, in which the most likely mechanism of myocardial ischemia was extrinsic compression of a coronary artery by an intrapericardial mass with magnetic resonance imaging features of a teratodermoid tumor. A 47-year-old woman was admitted with clinical signs of acute coronary syndrome with ST-segment elevation. Echocardiography revealed regional left ventricular wall motion abnormalities and a mass in the pericardial cavity adjacent to the anterior and anterolateral walls of the left ventricle. Contrast-enhanced cardiac magnetic resonance imaging showed a well-defined heterogeneous mass measuring 33 × 43 × 41 mm with features consistent with a teratodermoid lesion. The differential diagnosis included cardiac and pericardial tumors, metastatic disease, and visceral syphilis. The patient refused biopsy for morphological verification of the mass, as well as surgical treatment. During four years of follow-up, clinical deterioration associated with progression of chronic heart failure was observed. Thus, this case demonstrates a rare “non-classical” cause of the clinical presentation of “classical” acute coronary syndrome and is intended to broaden physicians’ understanding of the etiology of myocardial ischemia.
For citation: Gasanov MZ, Sokolovskaya AV, Gasanova AV, Kolomatskaya OE, Chulkov VS, Veber VR. An intrapericardial mass with features of teratoma as a rare cause of acute coronary syndrome: A case report and 4-year follow-up. Therapy (Moscow). 2026;12(5S):132–137.
https://doi.org/10.18565/therapy.2026.5-s5.132-137
Ключевые слова
Список литературы
1. Glezer MG, Polyarnaya NG, Fomina TA, Vlasov YaV, Babkova NV. [Evaluation of the quality and availability of medical care for patients with cardiovascular diseases. Results of sociological research. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular Therapy and Prevention. 2023;22(4):43–56 (In Russ.)].
EDN: ZVVVFD. https://doi.org/10.15829/1728-8800-2023-3534
2. Samorodskaya IV, Bubnova MG, Akulova OA, Ostroushko NI, Drapkina OM. [Mortality rates from acute forms of coronary heart disease and sudden cardiac death in the regions of the Russian Federation in 2019–2021. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular Therapy and Prevention. 2023;22(5):6–16 (In Russ.)].
EDN: ZDOYLT. https://doi.org/10.15829/1728-8800-2023-3557
3. Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al.; ESC Scientific Document Group. 2023 ESC guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720–826.
PMID: 37622654. https://doi.org/10.1093/eurheartj/ehad191
4. Averkov OV, Harutyunyan GK, Duplyakov DV, Konstantinova EV, Nikulina NN, Shakhnovich RM, et al. [2024 clinical practice guidelines for acute coronary syndrome without ST segment elevation electrocardiogram. Rossiyskiy kardiologicheskiy zhurnal = Russian Journal of Cardiology. 2025;30(5):127–216 (In Russ.)].
EDN: CXJUIB. https://doi.org/10.15829/1560-4071-2025-6319
5. Waterbury TM, Tarantini G, Vogel B, Mehran R, Gersh BJ, Gulati R. Non-atherosclerotic causes of acute coronary syndromes. Nat Rev Cardiol. 2020;17(4):229–41.
PMID: 31582839. https://doi.org/10.1038/s41569-019-0273-3
6. Khattab E, Karelas D, Pallas T, Kostakis P, Papadopoulos CH, Sideris S, et al. MINOCA: A pathophysiological approach of diagnosis and treatment – a narrative review. Biomedicines. 2024;12(11):2457.
PMID: 39595023. PMCID: PMC11592352. https://doi.org/10.3390/biomedicines12112457
7. [Clinical guidelines. Tumors of the mediastinum. Association of Oncologists of Russia, Russian Society of Clinical Oncology. Rubricator of clinical guidelines of the Ministry of Healthcare of Russia. ID: 502_2. 2024. URL: https://cr.minzdrav.gov.ru/view-cr/502_2 (Accessed June 10, 2026) (In Russ.)].
8. Rychik J, Khalek N, Gaynor JW, Johnson MP, Adzick NS, Flake AW, Hedrick HL. Fetal intrapericardial teratoma: Natural history and management including successful in utero surgery. Am J Obstet Gynecol. 2016;215(6):780.e1–780.e7.
PMID: 27530489. https://doi.org/10.1016/j.ajog.2016.08.010
9. Federici D, Marcora S, Trezzi R, Galletti L. Neonatal intrapericardial teratoma. J Card Surg. 2018;33(5):296–97.
PMID: 29629514. https://doi.org/10.1111/jocs.13571
10. Kucherov YuI, Zhirkova YuV, Tarayan MV, Rekhviashvili MG, Shishkina TN, Miroshnichenko VP. [A case of successful surgical treatment of intrapericardial teratoma in a newborn baby. Detskaya khirurgiya = Russian Journal of Pediatric Surgery. 2016;20(1):53–55 (In Russ.)].
EDN: VLEIEV. https://doi.org/10.18821/1560-9510-2016-20-1-53-55
11. Gonzalez M, Krueger T, Schaefer SC, Ris HB, Perentes JY. Asymptomatic intrapericardial mature teratoma. Ann Thorac Surg. 2010;89(6):e46–47.
PMID: 20494011. https://doi.org/10.1016/j.athoracsur.2010.03.023
12. Watanabe H, Kanauchi N, Suzuki J, Matsuo S, Shiono S. Asymptomatic mature intrapericardial teratoma in an adult: A case report of a rare condition. Surg Case Rep. 2024;10(1):103.
PMID: 38678494. PMCID: PMC11056345. https://doi.org/10.1186/s40792-024-01902-0
13. Trivedi JK, Raman Kumar GV, Damodar Rao K. Intrapericardial dermoid cyst presenting with acute coronary syndrome. ANZ J Surg. 2019;89(4):430–31.
PMID: 28752610. https://doi.org/10.1111/ans.14090
14. Cohen R, Mirrer B, Loarte P, Navarro V. Intrapericardial mature cystic teratoma in an adult: Case presentation. Clin Cardiol. 2013;36(1):6–9.
PMID: 23007804. PMCID: PMC6649387. https://doi.org/10.1002/clc.22051
15. Gatti M, D’Angelo T, Muscogiuri G, Dell’aversana S, Andreis A, Carisio A, et al. Cardiovascular magnetic resonance of cardiac tumors and masses. World J Cardiol. 2021;13(11):628–49.
PMID: 34909128. PMCID: PMC8641001. https://doi.org/10.4330/wjc.v13.i11.628
16. De Maria E. Approach to cardiac masses: Thinking inside and outside the box. World J Clin Cases. 2024;12(28):6132–36.
PMID: 39371558. PMCID: PMC11362886. https://doi.org/10.12998/wjcc.v12.i28.6132
17. Kucherov YuI, Zhirkova YuV, Tarayan MV, Samorokovskaya MV, Shvets LV. [Surgical treatment of a newborn in critical condition with intrapericardiac teratoma: A case report. Rossiyskiy vestnik detskoy khirurgii, anesteziologii i reanimatologii = Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care. 2021;11(2):169–75 (In Russ.)].
EDN: VKVKZP. https://doi.org/10.17816/psaic954
18. Tolstolutskaya AO, Gasanov MZ, Kolosova AV, Fomenko EP. [A case of typical clinical presentation of acute coronary syndrome associated with an atypical cause. In: Materials of the XIII Interregional Scientific and Practical Conference of Young Scientists with International Participation on Current Issues of Internal Pathology “Zavadsky Readings”. Rostov-on-Don: Rostov State Medical University. 2018; pp. 251–53 (In Russ.)]. EDN: YXLBWO.
Об авторах / Для корреспонденции
Mitkhat Z. Gasanov, MD, PhD (Medicine), associate professor of the Department of hospital therapy, deputy director of the Medical Institute, Yaroslav-the-Wise Novgorod State University, Veliky Novgorod, Russian Federation.E-mail: mitkhat.gasanov@novsu.ru
ORCID: https://orcid.org/0000-0001-5856-0404. Scopus ID: 57200421886. eLibrary SPIN: 1236-0012
Anastasia V. Sokolovskaya, MD, cardiologist at the Cardiology Center of the Rostov Regional Clinical Hospital (RRCH No. 1), Rostov-on-Don, Russian Federation.
E-mail: nastyakolos154@yandex.ru
ORCID: https://orcid.org/0009-0002-0132-187X
Anastasiya V. Gasanova, MD, assistant at the Department of hospital therapy of the Medical Institute, Yaroslav-the-Wise Novgorod State University, Veliky Novgorod, Russian Federation.
E-mail: anastasiyaagasanova@gmail.com
ORCID: https://orcid.org/0009-0004-0853-7715. eLibrary SPIN: 5954-4922
Olga E. Kolomatskaya, MD, PhD (Medicine), associate professor of the Department of internal medicine No. 1, Rostov State Medical University, Rostov-on-Don, Russian Federation.
E-mail: okolomackaya@mail.ru
ORCID: https://orcid.org/0000-0003-2888-3194. Scopus ID: 57210175260. eLibrary SPIN: 1185-7348
Vasiliy S. Chulkov, MD, Dr. Sci. (Medicine), professor, head of the Department of hospital therapy, director of the Medical Institute, Yaroslav-the-Wise Novgorod State University, Veliky Novgorod, Russian Federation.
E-mail: vasily.chulkov@novsu.ru
ORCID: https://orcid.org/0000-0002-0952-6856. Scopus ID: 55246314800. eLibrary SPIN: 8001-0051
Viktor R. Veber, MD, Dr. Sci. (Medicine), professor, academician of the Russian Academy of Sciences,head of the Department of Internal medicine, scientific director of the Medical Institute, Yaroslav-the-Wise Novgorod State University, Veliky Novgorod, Russian Federation.
E-mail: viktor.veber@novsu.ru
ORCID: https://orcid.org/0000-0001-7854-0849. Scopus ID: 58378839300. eLibrary SPIN: 8893-1970



