Плейотропные эффекты гимекромона в терапии хронических заболеваний печени и билиарного тракта
Аннотация. Фиброз печени является распространенным конечным результатом хронического повреждения гепатоцитов. Клинический прогресс в разработке препаратов против фиброза печени набирает обороты: к ним относятся различные лекарственных средств, включая гимекромон (4-MU). Цель – оценить противовоспалительную и антифибротическую эффективность гимекромона у пациентов с сочетанной патологией билиарного тракта и печени. Материалы и методы. В исследовании приняли участие 55 пациентов (31 женщина и 24 мужчины) 18–75 лет с хроническими гепатитами различной этиологии и фиброзом печени (F 1–4) в сочетании с билиарной патологией. Исследование закончили 20 пациентов. Всем участникам назначался гимекромон по 200 мг 3 раза/сут. в течение 3 нед. с последующим перерывом в 1 нед., курс повторялся в течение 6 мес. Также все пациенты получали урсодезоксихолевую кислоту в дозе 10 мг/кг массы тела на ночь постоянно на протяжении 6 мес. Результаты. Все пациенты на фоне проводившейся терапии отмечали улучшение самочувствия, повышение физической активности и работоспособности. Также у них отмечались статистически значимое снижение уровня биохимических маркеров (р = 0,001–0,049) и положительные статистически значимые изменения показателей фиброэластометрии (p <0,001) через 6 мес. наблюдения. Заключение. Назначенная нами схема лечения продемонстрировала выраженную антифибротическую эффективность (р = 0,001), а также сопровождалась статистически значимым снижением печеночных маркеров. Необходимо продолжать исследования по применению гимекромона (4-MU) при хронических заболеваниях печени.Е.Ю. Плотникова, Л.Г. Вологжанина, С.Р. Дружинина, М.А. Синьков, Ю.В. Котелевцев
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Об авторах / Для корреспонденции
Екатерина Юрьевна Плотникова, д. м. н., профессор, профессор кафедры последипломного образования и сестринского дела, руководитель курса клинической гастроэнтерологии, ФГБОУ ВО КемГМУ Минздрава России, Кемерово, Российская Федерация.E-mail: eka-pl@rambler.ru
ORCID: https://orcid.org/0000-0002-6150-1808
Людмила Георгиевна Вологжанина, к. м. н., доцент кафедры факультетской терапии № 1 ФГБОУ ВО ПГМУ им. академика Е.А. Вагнера Минздрава России, директор ООО «ГАСТРОЦЕНТР», Пермь, Российская Федерация.
E-mail: ludovica@mail.ru
ORCID: https://orcid.org/0000-0003-3105-4645
Софья Романовна Дружинина, врач-гастроэнтеролог ООО «ГАСТРОЦЕНТР», Пермь, Российская Федерация.
Максим Алексеевич Синьков, к. м. н., сердечно-сосудистый хирург ФГБНУ «НИИ КПССЗ», Кемерово, Российская Федерация.
E-mail: fox2you@mail.ru
ORCID: https://orcid.org/0000-0002-2494-8694. Scopus ID: 57189646155. eLibrary SPIN: 8327-3979
Юрий Васильевич Котелевцев, д. б. н., профессор ЦБМТ АНОО ВО «Сколтех», Москва, Российская Федерация.
E-mail: y.kotelevtsev@skoltech.ru
ORCID: https://orcid.org/0000-0002-7255-7794. Scopus ID: 7003856033



