Possibilities of the analgesic action of botulinum therapy in clinical practice


DOI: https://dx.doi.org/10.18565/therapy.2018.7-8.52-56

О.Р. Orlova, A.Yu. Alekseeva, Z.N. Konovalova, E.V. Kostenko, D.A. Krasavina, L.R. Mingazova, M.I. Soykher

1 Department of nervous diseases of «I.M. Sechenov First Moscow Medical University» FSAEI of the of the Ministry of Healthcare of Russia (Sechenov University); 2 Central Institute of botulinum therapy and actual neurology; 3 Department of Public Health and Healthcare, Economics of Healthcare of PF, Pediatric Faculty of N.I. Pirogov Russian National Research Medical University FSAEI HE of the Ministry of Healthcare of Russia; 4 «Moscow Scientific and Practical Center for medical rehabilitation, restorative and sports medicine» Autonomous Public Health Care Institution of the Moscow Healthcare Department; 5 Department of surgical childhood diseases of FSBEI of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Healthcare of Russia; 6 Department of traumatology, orthopedics, medical and social assessment, prosthetics and rehabilitation of FSBI FVE at the «St. Petersburg Institute for the Advanced Training of Expert Doctors» of the Ministry of Labor of Russia; 7 Center for interdisciplinary dentistry and neurology; 8 «Moscow Regional Dental Clinic» Autonomous Public Health Care Institution
The article deals with the problem of pain syndromes in various neurological disorders: cervical dystonia, chronic migraine, myofascial pain syndrome, bruxism. It contains the data of clinical studies, as well as systematic reviews, justifying the effectiveness and safety of botulinum therapy for these diseases and conditions. Data on the antinociceptive action of type A botulinum neuroprotein are introduced, and new areas of its clinical application are indicated.
Keywords: pain, botulinum toxin, chronic migraine, focal dystonias, bruxism
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    • About the Autors

    Olga R. Orlova, MD, professor of the Department of nervous diseases of the Institute of Professional Education of «I.M. Sechenov First Moscow Medical University» FSAEI of HE of the Ministry of Healthcare of Russia, President of the Interregional Public Organization of botulinum therapy specialists (MOOSBT), head of the Central Institute of botulinum therapy and actual neurology. Address: 119991, Moscow, 8, build 2, Trubetskaya St. Tel. +79037206227. E-mail: ororlova@yandex.ru
    Anna Y. Alekseeva, 6th year student of the Faculty of General Medicine of «I.M. Sechenov First Moscow Medical University» FSAEI of HE of the Ministry of Healthcare of Russia. Address: 119991, Moscow, 8, build 2, Trubetskaya St. Tel. +79277176618.
    Zagidat N. Konovalova, PhD, a member of the MOOSBT. Address: 143903, Moscow region, Balashikha district, Balashikha, 4 Zavodskoy passage St., office1.
    Elena V. Kostenko, MD, associate professor of the Department of public Health and Healthcare, Healthcare Economics of Pediatric Faculty of «N.I. Pirogov Russian National Research Medical University» FSAEI of HE of the Ministry of Healthcare of Russia, head of a branch of the State Autonomous Healthcare Institution «Moscow Scientific and Practical Center for medical rehabilitation, restorative and sports medicine of the Department of Healthcare of Moscow», a MOOSBT member. Address: 117997, Moscow, 1 Ostrovityanova St. Tel.: +74954347121.
    Diana A. Krasavina, MD, professor of the Department of surgical diseases of pediatric age, «St. Petersburg State Pediatric Medical University» FSAEI of HE of the Ministry of Healthcare of Russia, head of the Department of traumatology and orthopedics, medical and social assessment, prosthetics and rehabilitation at the St. Petersburg Institute for the advanced training of medical experts of the Ministry of Labor of Russia. Address: 194044, St. Petersburg, 11/12 Bolshoi Sampsonievsky Prospect St. Tel/ fax: +7812 5421445.
    Leniza R. Mingazova, PhD, a member of the MOOSBT. Address: 143903, Moscow region, Balashikha district, Balashikha, 4 Zavodskoy passage St., office 1.
    Marina I. Soikher, PhD, associate professor of the Department of Pediatric Dentistry and Orthodontics, Chief Doctor of «Moscow Regional Dental Clinic» State Autonomous Healthcare Institution. Address: 129110, .61⁄2, build1, Shchepkina St. Tel.: +74956817640.

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