Cytogenetic changes and lipid peroxidation in patients with gastroesophageal reflux disease in combination with metabolic syndrome


DOI: https://dx.doi.org/10.18565/therapy.2019.3.32-36

Tadtaeva D.J., Ranyuk L.G., Alikova S.K., Burduli N.M.

1) Institute of biomedical research of the Vladikavkaz scientific center of the Russian Academy of Sciences; 2) North Ossetian State medical Academy of the Ministry of healthcare of Russia, Vladikavkaz
Objective: to study cytogenetic changes in the esophageal mucosa and lipid peroxidation in patients with gastroesophageal reflux disease in combination with metabolic syndrome.
Material and methods. 122 patients with gastroesophageal reflux disease in combination with metabolic syndrome were examined. Cytogenetic changes in the esophageal mucosa and lipid peroxidation and antioxidant protection were evaluated during the examination.
Results. Differences in the frequency of cells with cytogenetic disorders in mucocytes of the distal esophageal mucosa in the group of patients with infected N. pylori was almost twice as high, and the level of lipid oxidation products in patients with esophagitis exceeded normal values.
Conclusion. The study indicates that in patients with gastroesophageal reflux disease in combination with metabolic syndrome, the inflammation process adversely affects the distal esophageal mucosa with respect to the genotoxicity of mucocytes, and the activation of lipid peroxidation occurs in all variants of the disease.
Keywords: cytogenetic study, gastroesophageal reflux disease, lipid peroxidation, metabolic syndrome
Read entire article

Literature


  1. Бокарев И.Н. Метаболический синдром. Клиническая медицина. 2014; 8: 71–75.

  2. Ефремов Л.И., Комиссаренко И.А. Метаболический континуум и полиморбидность в гериатрии. Экспериментальная и клиническая гастроэнтерология. 2014; 6(106): 4–7.

  3. Christian K. Roberts. Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training. Christian K. Roberts, Andrea L. Hevener, R. James Barnard. Compr. Physiol. 2013; 3 (1): 1–58.

  4. Корочина И.Э. Гастроэнтерологические аспекты метаболического синдрома. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2008; 1: 26–34.

  5. Харченко Н.В. Метаболический синдром в практике гастроэнтеролога. Здоровье Украины: гастроэнтерология, гепатология, колопроктология. 2015; 19; 42–46.

  6. Чернышова Е.Н., Панова Т.Н., Донская М.Г. Процессы перекисного окисления липидов и преждевременное старение при метаболическом синдроме. Кубанский научный медицинский вестник. 2013; 1(136): 181–184.

  7. Christian K. Roberts, Andrea L. Hevener, R. James Barnard. Compr. Physiol. 2013; 3(1): 1–58.

  8. Калаев В.Н., Красножон К.Б., Игнатова И.В. Оценка стабильности генома больных сахарным диабетом I типа с использованием микроядерного теста в буккальном эпителии. Фундаментальные исследования. 2012; 2(11): 288–295.

  9. Калашникова М.Ф. Метаболический синдром: современный взгляд на концепцию, методы профилактики и лечения. Эффективная фармакотерапия. Эндокринология. 2013; 6(55): 33–37.

  10. Учамприна В.А., Романцова Т.И., Калашникова М.Ф. Метаболический синдром: аргументы за и против. Ожирение и метаболизм. 2012; 2(2): 17–27.

  11. Китаева Л.В. Цитогенетические нарушения в слизистой оболочке фундального отдела желудка у пациентов с хроническим гастритом. Экологическая генетика человека. 2010; 1(8): 36–41.


About the Autors

Diana Y. Tadtaeva, PhD, assistant of the Department of internal diseases №5 of the North Ossetian state medical Academy of the Ministry of Healthcare of Russia, researcher of the Department of new medical technologies and restorative medicine of the Vladikavkaz scientific center of the Russian Academy of Sciences. Address: 362019, Republic of North Ossetia – Alania, Vladikavkaz, 40 Pushkinskaya str. Tel.: +7 (928) 065-39-55. E-mail: zalina_coral@mail.ru
Larisa G. Ranyuk, PhD, associate professor of the Department of internal diseases №5 of the North Ossetian state medical Academy of the Ministry of Healthcare of Russia, researcher of the Department of new medical technologies and restorative medicine of the Vladikavkaz scientific center of the Russian Academy of Sciences. Address: 362019, Republic of North Ossetia – Alania, Vladikavkaz, 40 Pushkinskaya str. Tel.: +7 (905) 489-63-73. E-mail: ranlarisa@yandex.ru
Svetlana K. Alikova, MD, associate professor of the Department of internal diseases №5 of the North Ossetian State medical Academy of the Ministry of Healthcare of Russia, Head of the Department of new medical technologies and restorative medicine of the Vladikavkaz scientific center of the Russian Academy of Sciences. Address: 362021, Republic of North Ossetia – Alania, Vladikavkaz, 27 Sevastopolskaya str. Tel.: +7 (918) 822-88-33. E-mail: GutnovaSK@yandex.ru
Nikolay M. Burduli, MD, professor, Head of the Department of internal diseases №5 of the North Ossetian State medical Academy of the Ministry of Healthcare of Russia, Director of the Institute of biomedical research of the Vladikavkaz scientific center of the Russian Academy of Sciences. Address: 362025, Republic of North Ossetia – Alania, Vladikavkaz, 47 Pushkinskaya str. Tel.: +7 (988) 875-27-88. E-mail: burduli@yandex.ru


Similar Articles

Back to Content

Бионика Медиа