Proton pump inhibitors and the risk of pneumonia: how dangerous is it to use these drugs during the COVID-19 pandemic?


DOI: https://dx.doi.org/10.18565/therapy.2021.1.78-82

Moroz E.V., Karateev A.E.

1) N.N. Burdenko Мain Military Clinical Hospital of the Ministry of Defence of Russia, Moscow; 2) V.A. Nasonova Research Institute of Rheumatology, Moscow
Abstract. The problem of the COVID-19 pandemic is a priority for the global medical community. One of the central themes discussed in the light of optimizing disease prevention is potential negative impact of a number widely used in therapeutic practice medicines on COVID-19 development. Thus, the subject of discussion was the safety of proton pump inhibitors (PPIs): there is information that their use is associated with an increased risk of community-acquired pneumonia development. In recent months, a number of studies demonstrating the connection between regular PPIs’ use and the risk of severe COVID-19 forms development have been published. However, in many situations, the use of this class of medicines is vital. Consequentially, the prescription of thesemedicines during the COVID-19 pandemic should be carried out for clear indications, after carefully assessing the possible benefits and potential harm.
Keywords: COVID-19, proton pump inhibitors, complications, pneumonia
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About the Autors

Elena V. Moroz, PhD, head of gastroenterological Department of N.N. Burdenko Мain Military Clinical Hospital of the Ministry of Defence of Russia. Address: 105229, Moscow, 3 Gospital`naya Sq. Tel.: +7 (499) 263-55-55 (add. 5100). E-mail: evmoroz777@rambler.ru. ORCID: 0000-0003-0439-6287
Andrey E. Karateev, MD, head of the laboratory of pathophysiology of clinical polymorphism of musculoskeletal diseases of V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34A Kashirskoe highway. Tel.: +7 (910) 404-11-60. E-mail: aekarat@yandex.ru. ORCID: 0000-0002-1391-0711

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