The effect of anemia on the quality of life in patients with cardiovascular pathology
DOI: https://dx.doi.org/10.18565/therapy.2021.3.68-73
Denisova E.Yu., Zheleznyakova N.A., Kalyuta T.Yu., Posnenkova O.M., Kiselev A.R., Schwartz Yu.G., Gridnev V.I.
1) Saratov Medical University «REAVIZ»;
2) V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia;
3) National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of Russia, Moscow
Abstract. The article reviews the data on the quality of life (QOL) of patients with cardiovascular pathology accompanied by anemia as well as the impact of anemia correction on QOL. Studies from Elibrary, PubMed and clinicaltrials.gov databases were analyzed in the period since 2015 till 2020. Anemia has been shown to have a negative impact on QOL of patients with chronic heart failure. There was a little data on the impact of anemia on QOL of patients with coronary artery disease and the impact of anemia correction on QOL of cardiac patients. It is necessary to develop questionnaire validated for patients with anemia and cardiovascular pathology.
Keywords: anemia, quality of life, coronary artery disease, chronic heart failure, questionnaires for assessing the quality of life in cardiac patients with anemia
Literature
- Kassebaum N.J., Jasrasaria R., Naghavi M. et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014; 123(5): 615–24. doi: 10.1182/blood-2013-06-508325.
- Chaparro C.M., Suchdev P.S. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann N Y Acad Sci. 2019; 1450(1): 15–31. doi:10.1111/nyas.14092.
- Жолдасбекова А.С., Калматаева Ж.А. Современные подходы к изучению качества жизни в медицине и кардиологии (литературный обзор). Вестник Казахского национального медицинского университета. 2016; 3: 246–251. [Zholdasbekova A.S., Kalmataeva ZH.A. Modern approaches to study of the quality of life in medicine and cardiology (literature review). Vestnik Kazakhskogo natsional’nogo meditsinskogo universiteta = Bulletin of the Kazakh National Medical University. 2016; 3: 246–251 (In Russ.)].
- Kraai I.H., Luttik M.L., Johansson P. et al. Health-related quality of life and anemia in hospitalized patients with heart failure. Int J Cardiol. 2012; 161(3): 151–55. doi: 10.1016/j.ijcard.2012.05.036.
- Streng K.W., Nauta J.F., Hillege H.L. et al. Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction. Int J Cardiol. 2018; 271: 132–39. doi: 10.1016/j.ijcard.2018.04.001.
- Metivier F., Marchais S.J., Guerin A.P. et al. Pathophysiology of anaemia: focus on the heart and blood vessels. Nephrol Dial Transplant. 2000; 15 Suppl 3: 14–18. doi: 10.1093/oxfordjournals.ndt.a027970.
- Рындина Н.Г., Кравчун П.Г., Титова А.Ю., Рынчак П.И. Динамика параметров качества жизни и депрессивных расстройств при лечении больных с анемическим синдромом на фоне хронической сердечной недостаточности ишемического генеза. Вісник проблем біології і медицини. 2013; 2: 147–150. [Ryndina N. G., Kravchun P. G., Tytova G. Yu., Rynchak P. I. Dynamics of quality of life parameters and depressive disorders in patients with anemic syndrome on a background of chronic heart failure of ischemic origin. Vestnik problem biologii I mediciny = Bulletin of problems of biology and medicine. 2013; 2: 147–150 (In Russ.)].
- Comín-Colet J., Martín Lorenzo T., Gonzalez-Domínguez A. et al. Impact of non-cardiovascular comorbidities on the quality of life of patients with chronic heart failure: a scoping review. Health Qual Life Outcomes. 2020; 18(1): 329. doi: 10.1186/s12955-020-01566-y.
- Adams K.F. Jr., Piña I.L., Ghali J.K. et al. Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure. Am Heart J. 2009; 158(6): 965–71. doi: 10.1016/j.ahj.2009.10.015.
- Enjuanes C., Klip I.T., Bruguera J. et al. Iron deficiency and health-related quality of life in chronic heart failure: results from a multicenter European study. Int J Cardiol. 2014; 174(2): 268–75. doi: 10.1016/j.ijcard.2014.03.169.
- von Haehling S., Jankowska E.A., van Veldhuisen D.J. et al. Iron deficiency and cardiovascular disease. Nat Rev Cardiol. 2015; 12(11): 659–69. doi: 10.1007/s40138-016-0117-y.
- Magrì D., De Martino F., Moscucci F. et al. Anemia and iron deficiency in heart failure: Clinical and prognostic role. Heart Fail Clin. 2019; 15(3): 359–69. doi: 10.1016/j.hfc.2019.02.005.
- Wienbergen H., Pfister O., Hochadel M. et al. RAID-HF (Registry Analysis of Iron Deficiency-Heart Failure) Study Group. Long-term effects of iron deficiency in patients with heart failure with or without anemia: the RAID-HF follow-up study. Clin Res Cardiol. 2019; 108(1): 93–100. doi: 10.1007/s00392-018-1327-y.
- Comin-Colet J., Enjuanes C., González G. et al. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status. Eur J Heart Fail. 2013; 15(10): 1164–72. doi:10.1093/eurjhf/hft083.
- Tyminska A., Kapłon-Cieslicka A., Ozieranski K. et al. Anemia at hospital admission and its relation to outcomes in patients with heart failure (from the Polish cohort of 2 European Society of Cardiology Heart Failure Registries). Am J Cardiol. 2017; 119(12): 2021–29. doi: 10.1016/j.amjcard.2017.03.035.
- Dinatolo E., Dasseni N., Metra M. et al. Iron deficiency in heart failure. J Cardiovasc Med (Hagerstown). 2018; 19(12): 706–16. doi: 10.2459/jcm0000000000000686.
- Savarese G., Jonsson A., Hallberg A.C. at al. Prevalence of, associations with, and prognostic role of anemia in heart failure across the ejection fraction spectrum. Int J Cardiol. 2020; 1(298): 59–65. doi: 10.1016/j.ijcard.2019.08.049.
- Effect of IV iron in patients with heart failure with preserved ejection fraction (FAIR-HFpEF). Clinical Trial NCT 03074591. URL: https://clinicaltrials.gov/ct2/show/NCT03074591?term=NCT03074591&draw=2&rank=1 (date of access – 19.03.2021).
- The TARGET-EFT trial (MulTicomponent Acute Intervention in FRail GEriatric PaTients with cardiovascular disease using the Essential Frailty Toolset). Clinical Trial NCT04291690. URL: https://clinicaltrials.gov/ct2/show/NCT04291690?term=NCT04291690&draw=2&rank=1 (date of access – 19.03.2021).
About the Autors
Elena Yu. Denisova, 4th year student of medical Faculty of Saratov Medical University «REAVIZ». Адрес: 410012, Saratov, 10 Verkhny rynok Str. Tel.: +7 (937) 635-43-39. E-mail: voronina_1994@mail.ru. ORCID: 0000-0002-1082-8130
Natalia A. Zheleznyakova, PhD, senior researcher of the Department of preventive cardiology and rehabilitation of Research Institute of Cardiology, assistant of the Department of faculty therapy, Faculty of general medicine of V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol`shaya Kazach`ya Str. Tel.: +7 (906) 316-95-98. E-mail: natzheleznyakova@yandex.ru. ORCID: 0000-0002-7890-8305
Tatiana Yu. Kalyuta, PhD, senior researcher of the Department of preventive cardiology and rehabilitation, Research Institute of Cardiology of V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol`shaya Kazach`ya Str. Tel.: +7 (905) 386-71-23. E-mail: tatianakaluta@yandex.ru. ORCID: 0000-0003-3172-0804
Olga M. Posnenkova, MD, head of the Department of atherosclerosis and chronic coronary artery disease, Research Institute of Cardiology of V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol`shaya Kazach`ya Str. Tel.: +7 (905) 380-39-07. E-mail: posnenkova@cardio-it.ru. ORCID: 0000-0001-5311-005X
Anton R. Kiselev, MD, associate professor, head of the Department of novel cardiology information technology, Research Institute of Cardiology of V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia, head of Coordinating Center for Fundamental Research, National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol`shaya Kazach`ya Str. Tel.: +7 (906) 312-22-16. E-mail: antonkis@list.ru. ORCID: 0000-0003-3967-3950
Yuri G. Schwartz, MD, professor, Director of the Faculty Therapy Clinic, head of Department of faculty therapy, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol`shaya Kazach`ya Str. Tel.: +7 (927) 220-11-01. E-mail: shwartz58@yandex.ru. ORCID: 0000-002-5205-7311
Vladimir I. Gridnev, MD, associate professor, Director of the Research Institute of Cardiology of V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol`shaya Kazach`ya Str. Tel.: +7 (8452) 39-39-78. E-mail: gridnev@cardio-it.ru. ORCID: 0000-0001-6807-7934