Decompensation of cardiovascular disease in infection SARS-CoV-2


DOI: https://dx.doi.org/10.18565/therapy.2021.4.90-94

Melnikova L.V., Lokhina T.V., Berenshtein N.V.

1) Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia, Moscow; 2) Penza Institute for Further Training of Physicians – branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia
Abstract. Patients with cardiovascular pathology have a high risk of severe disease course and death in new coronavirus infection COVID-19. One of the key aspects of pathogenesis in such cases is disorders in the platelet link of hemostasis, which predisposes to the development of venous thrombosis and thromboembolism of the pulmonary artery. A clinical case of decompensation of cardiovascular disease in a patient with SARS-CoV-2 infection without typical clinical signs of coronavirus infection is considered.

Literature



  1. Huang C., Wang Y., Li X. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223): 497–506. doi: 10.1016/S0140-6736(20)30183-5.

  2. Guzik T.J., Mohiddin S.A., Dimarco A. et al. COVID-19 and the cardiovascular system implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research. 2020; 116(10):1666–87. doi: 10.1093/cvr/cvaa106.

  3. Xiong T.Y., Redwood S., Prendergast B. et al. Coronaviruses and the cardiovascular system: acute and longterm implications. Eur Heart J. 2020; 0: 1–3. doi: 10/1093/eurheartj/ehaa231.

  4. Kochi A.N., Tagliari A.P., Forleo G.B. et al. Cardiac and arrhythmic complications in patients with COVID-19. J Cardiovascuc Electrophysiol. 2020; 31(5): 1003–08. doi.org/10.1111/jce.14479.

  5. Walls A.C., Park Y.J., Tortorici M.A. et al. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020; 181(2): 281–92.e6. doi: 10.1016/j.cell.2020.02.058.

  6. Коган Е.А., Березовский Ю.С., Проценко Д.Д. с соавт. Патологическая анатомия инфекции, вызванной SARS-CoV-2. Судебная медицина. 2020; 2: 8–30. [Kogan E.A., Berezovsky Yu.S., Protsenko D.D. et al. Pathological Anatomy of Infection Caused by SARS-CoV-2. Sudebnaya meditsina = Russian Journal of Forensic Medicine. 2020; 2: 8–30 (In Russ.)]. doi: https://dx.doi.org/10.19048/2411-8729-2020-6-2-8-30.

  7. Bansal M. Cardiovascular disease and COVID-19. Diabetes Metab Syndr. 2020; 14(3): 247–50. doi: 10.1016/j.dsx.2020.03.013.

  8. Рекомендации ESC по диагностике и лечению острой легочной эмболии, разработанные в сотрудничестве с Европейским респираторным обществом (ERS), 2019. Российский кардиологический журнал. 2020; 8: 3848. [2019 ESC Guidelines for the diagnosis and management of acute pulmonaryembolism developed in collaboration with the European Respiratory Society (ERS). Rossiyskiy kardiologicheskiy zhurnal = Russian Journal of Cardiology. 2020; 8: 3848 (In Russ.)]. doi: https://doi.org/10.15829/1560-4071-2020-3848.

  9. Bikdeli B., Madhavan M.V., Jimenez D. et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review. J Am Coll Cardiol. 2020; 75(23): 2950–73. doi: 10.1016/j.jacc.2020.04.031.

  10. Lew T.W., Kwek T.K., Tai D. et al. Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome. JAMA. 2003; 290(3): 374–80. doi: 10.1001/jama.290.3.374.

  11. Chong P.Y., Chui P., Ling A.E. et al. Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: challenges in determining a SARS diagnosis. Arch Pathol Lab Med. 2004; 128(2): 195–204. doi: 10.1043/1543-2165.

  12. Анаев Э.Х., Княжеская Н.П. Коагулопатия при covid-19: фокус на антикоагулянтную терапию. Практическая пульмонология. 2020; 1: 3–13. [Anaev E.K., Knyazheskaya N.P. Coagulopathy in COVID-19: focus on anticoagulant therapy. Prakticheskaya pul’monologiya = Practical pulmonology. 2020; 1: 3–13 (In Russ.)].

  13. Lippi G., Favaloro E.J. D-dimer is associated with severity of coronavirus disease 2019: A pooled analysis. Thromb Haemost. 2020; 120(5): 876–78. doi: 10.1055/s-0040-1709650.

  14. Lippi G., Plebani M., Henry B.M. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020; 506:145–48. doi: 10.1016/j.cca.2020.03.022.

  15. Tang N., Li D., Wang X. et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020; 18(4): 844–47. doi: 10.1111/jth.14768.

  16. Thachil J., Tang N., Gando S. et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost. 2020; 18(5): 1023–26. doi: 10.1111/jth.14810.

  17. Wang D., Hu B., Hu C. et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323(11): 1061–69. doi: 10.1001/jama.2020.1585.

  18. Буланов А.Ю., Симарова И.Б., Буланова Е.Л. с соавт. Новая коронавирусная инфекция COVID-19: клиническая и прогностическая значимость оценки фибриногена плазмы. Вестник интенсивной терапии им. А.И. Салтанова. 2020; 4: 42–47. [Bulanov A.Yu., Simarova I.B., Bulanova E.L. et al. New coronavirus infection COVID-19: clinical and prognostic significance of plasma fibrinogen level. Vestnik intensivnoy terapii im. A.I. Saltanova = Annals of Critical Care. 2020; 4: 42–47 (In Russ.)]. doi: https://doi.org/10.21320/1818-474X-2020-4-42-47.


About the Autors


Lyudmila V. Melnikova, MD, associate professor, professor of the Department of general medical practice and polyclinic therapy, Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia. Address: 125445, Moscow, 53 Smol`naya Str. Tel.: +7 (919) 969-96-71. E-mail: lumel2408@yandex.ru. ORCID: 0000-0003-4688-1272
Tatiana V. Lokhina, MD, head of the Department of therapy, cardiology, functional diagnostics and rheumatology, Penza Institute for Further Training of Physicians – branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia. Address: 440060, Penza, 8А Stasova Str. Tel.: +7 (905) 367-18-27. E-mail: ltv-13@mail.ru. ORCID: 0000-0002-9493-444X
Natalia V. Berenshtein, PhD, associate professor of the Department of ultrasound diagnostics, Penza Institute for Further Training of Physicians – branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia. Address: 440060, Penza, 8А Stasova Str. Tel.: +7 (964) 867-41-94. E-mail: berenshtein2011@yandex.ru. ORCID: 0000-0002-1589-2799


Similar Articles


Бионика Медиа