Русский
Influence of TGF-β1 expression on the development of tubulointerstitial fibrosis in patients with primary chronic glomerulonephritis
DOI: https://dx.doi.org/10.18565/therapy.2021.7.71-76
Mukhtarova A.V., Batyushin M.M., Sinelnik E.S., Antipova N.V., Gadaborsheva H.Z.
1) Rostov State Medical University of the Ministry of Healthcare of Russia, Rostov-on-Don; 2) Regional Clinical Hospital No. 2, Rostov-on-Don
Material and methods. The study included 75 patients (aged 18 to 80 years) with primary chronic glomerulonephritis in the acute phase, who underwent puncture nephrobiopsy if indicated. As a result of the immunohistochemical analysis of the biopsy, it was established: a weak degree of expression of TGF-β1 – in 15 biopsies, moderate - in 44, significant - in 15.
Results. When studying the effect of TGF-β1 on the severity of TIF, a directly proportional correlation relationship was established (r - 0.37; p <0.05). Expressed expression of TGF-β1 was noted in the epithelium of the proximal tubule. This effect is probably due to the fact that in the presence of damage, these cells can have a paracrine effect on the surrounding tissues.
Conclusion. TGF-β1 is involved in the development of irreversible changes in various parts of the nephron, which makes it possible to consider the studied marker as one of the potential prognostic criteria for the outcome of chronic kidney disease.
About the Autors
Aytan V. Mukhtarovna, the Head of the dialysis unit No. 2 “LLC DC NEFROS-DON”, post-graduate student of the Internal Medicine Department No. 2 of Rostov State Medical University. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane. Tel.: +7 (908) 510-81-51. E-mail: ayka.mukhtarova@gmail.com. ORCID: 0000-0001-6367-6727
Mikhail M. Batyushin, MD, PhD, DMedSci professor, professor of the internal medicine Department of No. 2, the Head of the nephrology Department of Rostov State Medical University Clinic of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane. Tel.: +7 (918) 501-88-01. E-mail: batjushin-m@rambler.ru. ORCID: 0000-0002-2733-4524
Elena A. Sinelnik, Candidate of Medical Sciences, the Head of the pathology Department of Regional Clinical Hospital No.2. Address: 344022, Rostov-on-Don, 3 Pervoy Konnoy Armii Str. Tel.: +7 (863) 252-19-30. E-mail: ob2p@mail.ru
Natalia V. Antipova, the Head of the nephrology Department of Regional Clinical Hospital No. 2. Address: 344022, Rostov-on-Don, 3 Pervoy Konnoy Armii Str. Tel.: +7 (863) 252-19-30. E-mail: ob2p@mail.ru
Hani Z. Gadaborsheva, Candidate of Medical Sciences, Nephrologist, Ingush Republican Clinical Hospital named after A.O. Akhushkov Address: 386101, Republic of Ingushetia, Nazran, st. Mutalieva 11. Tel.: 8 (928) 144-06-06
