Abstract. The analysis of literature data characterizing the prevalence, etiology, clinical course, localization of valvular injury, complications, diagnosis, treatment, prognosis and outcomes of infective endocarditis (IE) in various stages of HIV infection are presented. Aspects of tactics of management of patients with IE on the background of HIV infection, including those in the AIDS stage, are discussed: the features of drug therapy, indications for cardiac surgery. Further research is needed on various aspects of IE in the setting of HIV infection in order to improve diagnosis and prognosis. Effective interdisciplinary interaction of specialists (cardiologists, cardiac surgeons, infectious disease specialists) makes it possible to achieve in many cases the cure of valvular infection, reduction of viral load and restoration of cellular immunity, ensuring in the future a satisfactory quality of life for patients with infective endocarditis against the background of HIV infection.

Keywords: infective endocarditis, HIV/AIDS, injection drug addicts