Therapy » Chronic EBV infection in clinical practice: What should be considered when diagnosing

Chronic EBV infection in clinical practice: What should be considered when diagnosing

DOI: https://dx.doi.org/10.18565/therapy.2023.2.56-61

Nikolskiy M.A., Lioznov D.A., Malyavin A.G.
1) I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia; 2) A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, Saint Petersburg; 3) A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Abstract. Epstein–Barr virus (EBV) is ubiquitous pathogen, founded in 95% of population. After primary infection, EBV realizes life-long latency in B-lymphocytes and saliva. Periodic reactivation is not clinically important. Detection of IgG, EBV DNA in saliva, urine and in blood (less than 100 copies/ml) are the signs of latent infection, the treatment is unnecessary. In rare cases in immunocompromised and/or transplant patients clinically important reactivation occurs with development of chronic active form of EBV, lymphoproliferative disorders or malignization. The treatment of chronic active forms of EBV is vitally necessary.

Keywords: reactivation of EBV, chronic active form of EBV, post-transplant lymphoproliferative disorders, Epstein–Barr virus (EBV)

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About the Autors

Mikhail A. Nikolskiy, PhD in Medical Sciences, assistant at the Department of pediatrics, I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo Str. E-mail: nicolm@inbox.ru
Dmitry A. Lioznov, MD, professor, director of A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, head of the Department of infectious diseases and epidemiology, I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 15/17 Professora Popova Str. E-mail: dmitry.lioznov@influenza.spb.ru
Andrey G. Malyavin, MD, professor, professor of the Department of phthisiology and pulmonology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20 Delegatskaya Str. E-mail: maliavin@mail.ru

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