Patient with overactive urinary bladder at a therapist’s appointment: Algorithm of assistance


DOI: https://dx.doi.org/10.18565/therapy.2025.1.166-176

Mubarakshina O.A., Batishcheva G.A., Dronova Yu.M., Chernov S.Yu.

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia
Abstract. Overactive urinary bladder (OAUB) is a widespread medical and social problem that significantly impairs life quality of the patients. Taking into account the diversity of etiology and pathogenesis of this clinical syndrome, its correction requires a multidisciplinary approach involving doctors of various specialties, and in many cases, therapists and general practitioners can provide necessary assistance to patients. The key place in OAUB treatment strategy is occupied by medicamentous therapy, where first-line drugs are remedies with M-anticholinergic effect. Peculiarities of pharmacokinetics and pharmacodynamics of trospium chloride favorably distinguish it from other representatives of this pharmacotherapeutic group. Due to its hydrophilicity, it does not penetrate the blood-brain barrier and does not have adverse effects on the central nervous system and cognitive functions. Numerous clinical studies have confirmed the high efficacy and safety of trospium chloride in complex clinical cases associated with comorbidity and neurogenic urination disorders.

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About the Autors


Olga A. Mubarakshina, MD, PhD (Medicine), associate professor of the Department of clinical pharmacology, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya St.
E-mail: mubarakshina@mail.ru
ORCID: https://orcid.org/0000-0001-6799-6322
Galina A. Batishcheva, MD, Dr. Sci. (Medicine), professor of the Department of clinical pharmacology, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya St.
E-mail: bat13@mail.ru
ORCID: https://orcid.org/0000-0003-4771-7466
Yulia M. Dronova, MD, PhD (Medicine), associate professor of the Department of clinical pharmacology, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya St.
E-mail: y.dronova@yandex.ru
ORCID: https://orcid.org/0000-0003-4513-091X
Sergey Yu. Chernov, MD, PhD (Medicine), associate professor of the Department of clinical pharmacology, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya St.
E-mail: sergeych6868@mail.ru
ORCID: https://orcid.org/0009-0002-8900-7745


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