Renal dysfunction and cardiovascular risk in rheumatic arthritis patients


A.P. Rebrov, M.A. Tyapkina, O.G. Karpova

Federal State Budgetary Educational Institution of Higher Professional Education V.I. Razumovskii Saratov state medical university of the Ministry of Healthcare of the Russian Federation, Chair of hospital therapy of general medicine Deartment, Saratov
Objectives. To examine of the renal dysfunction in patients with rheumatoid arthritis (RA), to identify the relationship of these indicators with risk factors for cardiovascular disease (CVD). Material and methods. The study included 73 patients with RA at the age 18 to 60 years without an associated renal diseases. We investigated the urinary excretions of α1-microglobulin (α1-Mg), albumin (Al), enzymes and glomerular filtration rate. Results. The urinary excretion of α1-Mg, Al and enzymes in patients with RA was higher than in healthy individuals. The most early marker of renal dysfunction was α1-Mg. The concentration of α1-Mg in urine was higher than in controls even in patients with normal urinary albumin excretion. The markers of the renal dysfunction in patients with RA correlated with the features of the development of the RA and with risk factors for CVD. Conclusions. It is important to assess of the renal function for risk stratification of CVD in patients with RA.
Keywords: renal dysfunction, rheumatoid arthritis, cardiovascular disease
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    • About the Autors

    Andrey P. Rebrov, professor, MD, head of the Department of hospital therapy of general medicine faculty of V.I. Razumovskii Saratov state medical university of the Ministry of Healthcare of Russia. Address: 410012, Privolzhskii Federal Okrug, Saratov region, Saratov, 112 Bolshaya Kazachja Str. Tel.: +78452491437. E-mail: andreyrebrov@yandex.ru.
    Maria A. Tyapkina, PhD, assistant professor of hospital therapy Department of general medicine faculty of V.I. Razumovskii Saratov state medical university of the Ministry of Healthcare of Russia. Address: 410012, Privolzhskii Federal Okrug, Saratov region, Saratov, 112 Bolshaya Kazachja Str. Tel.: +78452491437. E-mail: mariya-tyapkina@yandex.ru
    Olga G. Karpova, PhD, professor assistant of hospital therapy Department of general medicine faculty of V.I. Razumovskii Saratov state medical university of the Ministry of Healthcare of Russia. Address: 410012, Privolzhskii Federal Okrug, Saratov region, Saratov, 112 Bolshaya Kazachja Str. Tel.: +78452491437. E-mail: lelya18101985@mail.ru


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