Case of primary antiphospholipid syndrome complicated by thrombotic kidney microangiopathy of with infective endocardite addition


DOI: https://dx.doi.org/10.18565/therapy.2018.5.122-127

V.Yu. Titov, K.V. Komissarova, D.A. Poddubnaya, A.B. Egorkina, LM Mamoyeva, N.A. Sokolova, E.T. Razumova, V.A. Kokorin

1 FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia, Moscow, Russia; 2 State Budgetary Healthcare Institution O.M. Filatov State Clinical Hospital № 15 of the Healthcare Department, Moscow, Russia
Antiphospholipid syndrome (AFS) is a symptom complex, which is manifested by thrombosis of vessels of different localization and caliber with obligatory presence of antiphospholipid antibodies in the blood. AFS is an acquired thrombophilic disease in which autoantibodies are produced not to the phospholipids of cell membranes per se, but to proteins interacting with phospholipids. This syndrome can affect several organ systems, so the problem of AFS is multidisciplinary. Clinical manifestations of AFS are quite nonspecific (thrombosis of different localization), therefore the diagnosis can be verified only by the presence of antiphospholipid antibodies. The presented clinical example illustrates the difficulties of diagnosing a disease that has occurred with the syndrome of renal failure and complicated by infective endocarditis.
Keywords: antiphospholipid syndrome, AFS-associated nephropathy, thrombotic microangiopathy of the kidneys, infective endocarditis
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    • About the Autors

    Vladimir Y. Titov, 6th year student of the general medicine faculty of FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia, Moscow, Russia.
    E-mail: avdtitov@gmail.com.
    Ksenia V. Komissarova, 6th year student of the general medicine faculty of FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia, Moscow, Russia. E-mail: komissarova_kv@mail.ru.
    Darya A. Poddubnaya, 6th year student of the general medicine faculty of FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia, Moscow, Russia. E-mail: dary-pod@yandex.ru.
    Alina B. Egorkina, 6th year student of the general medicine faculty of FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia, Moscow, Russia.
    E-mail: alina.egorkina.94@mail.ru.
    Lilia M. Mamoyeva, attending physician of the Hospital therapy Department №1 of FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia.
    Natalia A. Sokolova, MD, head of the 8th cardiology Department of the State Budgetary Healthcare Institution O.M. Filatov state clinical hospital № 15 of the Healthcare Department, Moscow. E-mail: natalasocolova.94@mail.ru.
    Ekaterina T. Razumova, PhD, Associate Professor of the Department of Hospital Therapy No. 1 of the FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia. E-mail: razumova@yandex.ru
    Valentin A. Kokorin, PhD, associate professor of the hospital therapy Department No. 1 of the FSBEI of Higher Education “N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia; e-mail: valentinkokorin@yahoo.com

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