Sharpe’s syndrome. Difficulties in diagnosis


DOI: https://dx.doi.org/10.18565/therapy.2018.7-8.133-138

Vardanyan A.G., Gordeev I.G., Soboleva V.N., Volov N.A., Mashukova Y.M., Bezdolnova E.O, Rymberg V.P, Ramazanova E.S, Nazaryan A.H

FSBEI of Higher Education « N.I. Pirogov Russian National Research University » Ministry of Health of Russia, Department of Hospital Therapy №1 of the Faculty of Medicine, Moscow
A modern doctor faces a huge number of similar or overlapping sympthoms and syndromes that comprise a disease pattern and need a thorough differential-diagnostic approach while diagnosis verification. In this connection a mixed connective tissue disease (MCTD) takes pride of place. Sharp’s syndrome is an autoimmune mixed connective tissue disease which is characterized by the presence of separate symptoms of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis (PM) and rheumatoid arthritis (RA), in combination with a high titer of anti-U1 ribonucleoprotein (RNP) antibodies. As a rule the prognosis of Sharp’s syndrome is favourable and a clinical remission is possible. However the presence of pulmonary hypertension, renal damage and severe Raynaud’s syndrome causes worse prognosis, which is described in the below mentioned clinical event.
Keywords: Sharpe’s syndrome, diffuse connective tissue diseases, autoimmune genesis, diagnostic difficulties
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    • About the Autors

    Argishti Gagikovich Vardanyan, assistant of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow,
    1 Ostrovityanova st. E-mail: argisht@mail.ru
    Valentina Nikolaevna Soboleva, MD PhD, Associate Professor of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow, 1 Ostrovityanova st. E-mail: vnsoboleva@yandex.ru
    Nikolai Alexandrovich Volov, MD PhD, Associate Professor of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow, 1 Ostrovityanova st. E-mail: drvolov@yandex.ru
    Yulia Mikhailovna Mashukova, MD PhD, Associate Professor of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow, 1 Ostrovityanova st. E-mail: alfilenko@rambler.ru
    Elena Olegovna Bezdolnova, a student of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow, 1 Ostrovityanova st. E-mail: e.bezdolnova@yandex.ru
    Varvara Pavlovna Rymberg, a student of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow, 1 Ostrovityanova st.
    Ella Sergeevna Ramazanova, a student of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow, 1 Ostrovityanova st.
    Ararat Khachikovich Nazaryan, a student of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow,
    1 Ostrovityanova st. E-mail: araratnazaryan@yandex.ru
    Ivan Gennadevich Gordeev, MD, Professor, Head of the Department of Hospital Therapy No. 1, Pirogov Russian National Research Medical University of the Ministry of Health care of Russia. The address: 117997, Moscow,
    1 Ostrovityanova st. E-mail: cardio-15@yandex.ru

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