Markers of calcium metabolism in calcific aortic valve disease


DOI: https://dx.doi.org/10.18565/therapy.2019.1.103-106

Baykulova M.Kh., Shcheglova E.V., Boeva O.I.

1 Regional clinical cardiology center, Stavropol; 2 FSBIHE «Stavropol State Medical University»
The aim of the study was to test the hypothesis about the association of blood levels of calcium metabolism markers, such as parathyroid hormone, vitamin D and ionized calcium, with calcifying aortic valve disease. Material and methods. The objects were 108 patients with tricuspid aortic valve calcification over the age of 65 years. Calcification and aortic valve stenosis were verified using transthoracic echocardiography. A comparison group consisted of 58 patients without signs of aortic valve pathology, comparable to the main group by sex, age, clinical features, anamnesis, structure of cardiovascular pathology and drug therapy. Serum concentrations of human intact parathyroid hormone and 25-hydroxy vitamin D were detected by ELISA. Results. In patients with calcifying aortic valve disease, serum concentrations of parathormone and ionized calcium were significantly lower. The 25OH level of vitamin D was significantly lower in women of the both groups. The correlation analysis has shown no association of parathyroid hormone and 25OH vitamin D with echocardiography and laboratory parameters. Conclusion. Thus, in patients with cardiovascular pathology, the presence of calcifying aortic valve disease is associated with lower serum concentrations of parathyroid hormone and ionized calcium, which may indicate their pathogenetic role in this disease.
Keywords: ionized calcium, calcific aortic valve disease, vitamin D, parathyroid hormone
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About the Autors

Madina Kh. Baykulova, cardiologist of the State Budgetary Healthcare Institution of the Stavropol Territory «Regional Clinical Cardiology Centre». Address: 355026, Stavropol, 224A Prigorodnaya str.
E-mail: m.baykulova@mail.ru
Elena V. Shcheglova, MD, PhD, head of outpatient Department of Stavropol regional clinical diagnostic center, associate professor of the Department of clinical physiology, cardiology and introscopy of the federal state budgetary institution of high education «Stavropol State Medical University» of the Ministry of Healthcare of the Russian Federation. Address: 355017, Stavropol, 310 Mira str. E-mail: smets_82@mail.ru
Olga Ig. Boeva, MD, PhD, head of the imaging Department of Stavropol with the course postgraduate education of the Federal state budgetary institution of high education «Stavropol State Medical University» of the Ministry of Healthcare of the Russian Federation. Address: 355017, Stavropol, 310 Mira str.
E-mail: box0271@mail.ru


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