The aim of the study was to test the hypothesis about the association of blood levels of calcium metabolism markers, such as parathyroid hormone, vitamin D and ionized calcium, with calcifying aortic valve disease. Material and methods. The objects were 108 patients with tricuspid aortic valve calcification over the age of 65 years. Calcification and aortic valve stenosis were verified using transthoracic echocardiography. A comparison group consisted of 58 patients without signs of aortic valve pathology, comparable to the main group by sex, age, clinical features, anamnesis, structure of cardiovascular pathology and drug therapy. Serum concentrations of human intact parathyroid hormone and 25-hydroxy vitamin D were detected by ELISA. Results. In patients with calcifying aortic valve disease, serum concentrations of parathormone and ionized calcium were significantly lower. The 25OH level of vitamin D was significantly lower in women of the both groups. The correlation analysis has shown no association of parathyroid hormone and 25OH vitamin D with echocardiography and laboratory parameters. Conclusion. Thus, in patients with cardiovascular pathology, the presence of calcifying aortic valve disease is associated with lower serum concentrations of parathyroid hormone and ionized calcium, which may indicate their pathogenetic role in this disease.

Keywords: ionized calcium, calcific aortic valve disease, vitamin D, parathyroid hormone