Combined drug therapy of post-traumatic osteoarthritis


DOI: https://dx.doi.org/10.18565/therapy.2019.6.44-49

Trofimov E.A., Mazurov V.I., Melnikov E.S.

I.I. Mechnikov North-Western State medical University of the Ministry of Healthcare of Russia, Saint Petersburg
As part of the original research we performed magnetic resonance imaging (MRI) with the technique of color T2-mapping of cartilage for the verification in the dynamics of structural changes of the cartilage of the knee joint in the early stages of post-traumatic knee joint osteoarthritis. It was found that a significant importance at this stage of the disease is not only the formation of osteophytes but also a decrease in the number of bonds of the collagen-proteoglycan complex and water molecules, reflected by such an important parameter as a change in the relaxation time of the T2-signal, which is detected by the T2-mapping technique.
During the 6-month study, we evaluated the influence of combined schemes of osteoarthritis therapy with the disease-modifying drugs on the clinical manifestations, as well as on the MRI-parameters of the early stages of the disease. Combined therapy with the usage of chondroprotective action drugs leads to a significant clinical improvement according to the questionnaires and slows the progression of chondrogenesis according to the MRI data with the usage of color T2-mapping of cartilage.
Keywords: chondroprotective action, color T2-mapping of cartilage, sodium hyaluronate, chondroitin sulfate, osteoarthritis
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About the Autors

Evgeniy A. Trofimov, PhD, associate professor of the Department of therapy, rheumatology, temporary incapacity and medical care quality expertise named after E.E. Eichwald of I.I. Mechnikov North-Western State medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya Str. Tel.: +7 (921) 978-86-26. E-mail: Evgeniy.trofimov@szgmu.ru
Vadim I. Mazurov, MD, professor, head of the Department of therapy, rheumatology, temporary incapacity and medical care quality expertise named after E.E. Eichwald of I.I. Mechnikov North-Western State medical University of the Ministry of Healthcare of Russia, honored scientist of the Russian Federation, academician of RAS. Address: 191015, Saint Petersburg, 41 Kirochnaya Str. Tel.: +7 (921) 951-71-88. E-mail: maz.nwgmu@yandex.ru
Evgeniy S. Melnikov, rheumatologist of the Department of rheumatology of Clinic named after E.E. Eichwald of I.I. Mechnikov North-Western State medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya Str. Tel.: +7 (921) 951-71-88. E-mail: melnikovevgeni1993@yandex.ru


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