Features of endothelial dysfunction and lipid metabolism on myocardial remodeling in patients with arterial hypertension in the highlands


DOI: https://dx.doi.org/10.18565/therapy.2019.8.96-103

Kurdanova M.H., Beslaneev I A., Martynov A.I., Kurdanova Mad.H., Batyrbekova L.M., Bugova L.A., Kurdanov H.A.

1) Center for medical and environmental research branch of Federal state budget institution of science State scientific center of Russian Federation – Institute of biomedical problems of the Russian Academy of Sciences, Nalchik; 2) Moscow State medical and dental University named after A.I. Evdokimov of the Ministry of Healthcare of Russia, Moscow; 3) Kabardino-Balkarian State University named after H.M. Berbekov
Objective: to study the concentration of nitric oxide metabolites and lipid profile features in left ventricular remodeling and the relationship between them in patients with arterial hypertension, residents of the highlands.
Material and methods. The study included 200 indigenous people in the Elbrus highlands: 130 patients with grade 1 and 2 hypertension and 75 healthy individuals. All examined patients underwent clinical, instrumental and biochemical examination, including: echocardiography and evaluation, determination of plasma lipids and stable metabolites of no in the blood.
Results. Myocardial remodeling was revealed in 46% of hypertension patients. With an increase in the degree of hypertension, a progressive decrease in NO production, an increase in lipid metabolism disorders, changes in myocardial geometry, an increase in the prevalence of concentric (KG) and eccentric (EG) left ventricular (LV) hypertrophy and a decrease in normal LV geometry (NG) were revealed.
Conclusion. The obtained data indicate a greater change in myocardial geometry, more frequent development of CD, KG and EG and hemodynamic disorders in patients with reduced no production in combination with a disturbed lipid profile and their close relationship with each other.
Keywords: arterial hypertension, myocardial remodeling, lipid profile, endothelial dysfunction, highlanders
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About the Autors

Mariam Kh. Kurdanova, PhD, lead researcher of the Department of clinical medicine and physiology of Center for medical and environmental research branch of Federal state budget institution of science State scientific center of Russian Federation – Institute of biomedical problems of the Russian Academy of Sciences. Address: 360022, Nalchik, 40/1 Shogentcukova Prospect. Tel.: +7 (622) 44-23-90; tel./fax: +7 (622) 44-31-55. E-mail: maryamk@mail.ru.
ORCID: 0000-0002-6966-8522.
Ilias A. Beslaneev, PhD, lead researcher of the Department of highlands physiology and pathology of Center for medical and environmental research branch of Federal state budget institution of science State scientific center of Russian Federation – Institute of biomedical problems of the Russian Academy of Sciences. Address: 360022, Nalchik, 40/1 Shogentcukova Prospect. Tel.: +7 (622) 44-23-90; тел/факс: +7 (622) 44-31-55. E-mail: ibisl@yandex.ru.
ORCID: 0000-0002-7294-6968.
Anatoly I. Martynov, MD, professor, RAS Academician, president of Russian scientific medical society of internal medicine. Address: 127473, Moscow, 20/1 Delegatskaya Str. Tel.: +7 (495) 609-67-00. E-mail: msmsu@msmsu.ru
Larisa A. Bugova, PhD, assistant of the Department of faculty therapy of Kabardino-Balkarian State University named after H.M. Berbekov. Address: 360004, Nalchik, 173 Chernyshevskogo Str. Тел. +7 (928) 690-65-55.
E-mail: lara_0708@mail.ru
Madina Kh. Kurdanova, PhD, Senior researcher of the Department of clinical medicine and physiology of Center for medical and environmental research branch of Federal state budget institution of science State scientific center of Russian Federation – Institute of biomedical problems of the Russian Academy of Sciences. Address: 360022, Nalchik, 40/1 Shogentcukova Prospect. Tel.: +7 (622) 44-23-90; tel./fax: +7 (622) 44-31-55. E- mail: kurdanovamh@ gmail.com. ORCID: 0000-0003-2592-8270.
Luiza M. Batyrbekova, PhD, lead researcher, head of the Department of clinical medicine and physiology of Center for medical and environmental research branch of Federal state budget institution of science State scientific center of Russian Federation – Institute of biomedical problems of the Russian Academy of Sciences. Address: 360022, Nalchik, 40/1 Shogentcukova Prospect. Tel.: +7 (622) 44-23-90; tel./fax: +7 (622) 44-31-55. E- mail: batyrbekova@gmail.com. ORCID: 0000-0002-0340-7565.
Khusein A. Kurdanov, MD, professor, Director of Center for medical and environmental research branch of Federal state budget institution of science State scientific center of Russian Federation – Institute of biomedical problems of the Russian Academy of Sciences. Address: 360022, Nalchik, 40/1 Shogentcukova Prospect. Tel.: +7 (622) 44-23-90; tel./fax: +7 (622) 44-31-55.. E-mail: kurdanov@yandex.ru. ORCID: 0000-0002-9240-0292.

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