Raynaud’s phenomenon in the early diagnosis of systemic scleroderma


DOI: https://dx.doi.org/10.18565/therapy.2019.8.151-156

Akhmetshina L.A., Tokranova L.V., Fatykhova E.Z., Yakupova S.P.

1) Kazan State medical University of the Ministry of Healthcare of Russia; 2) Scientific research medical Center «Vashe zdorovye», Kazan
Raynaud’s phenomenon (RP) is a multidisciplinary problem encountered by doctors of various specializations – vascular surgeons, physicians, rheumatologists, etc. There are primary and secondary Raynaud’s phenomena. Primary (idiopathic) RP is more common among the young and it covers 90% of the cases. Secondary RP develops as a result of various diseases or certain drug usage. Systemic scleroderma (SSD) is most commonly associated with the secondary RP. RP combined with an increased antinuclear factor titer allows detection of SSD’s early stage and referral to the rheumatologist.
Keywords: Raynaud’s phenomenon, digital ischemia, systemic diseases, systemic scleroderma, early stage, early diagnosis, differential diagnosis

Literature



  1. Алекперов Р.Т. Синдром Рейно в практике ревматолога. Современная ревматология. 2014; 2: 48–57.

  2. Raynaud M. Local Asphyxia and Symmetrical Gangrene of the Extremities. London: New Sydenham Society; 1862.

  3. Maricq H.R., Carpentier P.H., Weinrich M.C. et al. Geographic variation in the prevalence of Raynaud’s phenomenon: a 5-region comparison. J Rheumatol. 1997; 24: 879–89.

  4. Riera G., Vilardell M., Vaque J. et al. Prevalence of Raynaud’s phenomenon in a healthy Spanish population. J Rheumatol. 1993; 20(1): 66–69.

  5. De Angelis R., Salaffi F., Grassi W. Raynaud’s phenomenon: prevalence in an Italian population sample. Clin Rheumatol. 2006; 25(4): 506–10.

  6. Hughes M., Herrick A.L. Raynaud’s phenomenon. Best Pract Res Clin Rheumatol. 2016; 30(1): 112–32. doi: 10.1016/j.berh.2016.04.001

  7. Belch J. et al. ESVM guidelines – Raynaud’s phenomenon. Vasa. 2017; 46(6): 413–23.

  8. Maverakis E., Patel F., Kronenberg D.G. et al. International consensus criteria for the diagnosis of Raynaud’s phenomenon. J Autoimmun. 2014; 48–49: 60–65.

  9. Denton C.P., Khanna D. Systemic sclerosis. Lancet. 2017; 390(10103): 1685–99. doi:10.1016/S0140-6736(17)30933-9

  10. De Martinis M., Ciccarelli F., Sirufo M.M., Ginaldi L. An overview of environmental risk factors in systemic sclerosis. Expert Rev Clin Immunol. 2016; 12: 465–78.

  11. Marie I., Gehanno J.F. Environmental risk factors of systemic sclerosis. Semin Immunopathol. 2015; 37: 463–73.

  12. Конева О.А., Овсянникова О.Б., Старовойтова М.Н. с соавт. Определение чувствительности новых критериев системной склеродермии на российской популяции пациентов. Научно-практическая ревматология. 2015; 53(4): 361–66.

  13. Wu M., Assassi S., Salazar G.A. et al. Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients. Arthritis Res Ther. 2016; 18: 20.

  14. Bossini-Castillo L., Lopez-Isac E., Martin J. Immunogenetics of systemic sclerosis: defining heritability, functional variants and shared-autoimmunity pathways. J Autoimmun. 2015; 64: 53–65.

  15. Mahoney J.M., Taroni J., Martyanov V. et al. Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms. PLoS Comput Biol. 2015; 11: e1004005.

  16. Johnson S.R. New ACR EULAR guidelines for systemic sclerosis classification. Curr Rheumatol Rep. 2015; 17(5): 32. doi:10.1007/s11926-015-0506-3

  17. Российские клинические рекомендации. Ревматология. Под ред. Е.Л. Насонова. М.: ГЭОТАР-Медиа. 2019: 144–169.

  18. Bellando-Randone S., Matucci-Cerinic M. Very early systemic sclerosis and pre-systemic sclerosis: definition, recognition, clinical relevance and future directions. Curr Rheumatol Rep. 2017; 19(10): 65. Published 2017 Sep 18. doi:10.1007/s11926-017-0684-2

  19. Minier T., Guiducci S., Bellando-Randone S. et al. Preliminary analysis of the very early diagnosis of systemic sclerosis (VEDOSS) EUSTAR multicentre study: evidence for puffy fingers as a pivotal sign for suspicion of systemic sclerosis. Ann Rheum Dis. 2014; 73(12): 2087–93. doi:10.1136/annrheumdis-2013-203716


About the Autors


Leysan A. Akhmetshina, student of the medical faculty of Kazan State medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str. Tel.: +7 (843) 237-36-18. E-mail: atlasovna19@gmail.com
Lidiya V. Tokranova, student of the medical faculty of Kazan State medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str. Tel.: +7 (843) 237-36-18. E-mail: lidya-tokranova@mail.ru
Elza Z. Fatykhova, rheumatologist of the Scientific research medical Center «Vashe zdorovye». Address: 420043, Kazan, 52 Dostoevskogo Str. Tel.: +7 (843) 537-93-93. E-mail: elzafatykhova@mail.ru
Svetlana P. Yakupova, PhD, associate professor of the Department of hospital therapy of Kazan State medical University of the Ministry of Healthcare of Russia, Leading rheumatologist of the Ministry of Healthcare of the Republic of Tatarstan. Address: 420012, Kazan, 49 Butlerova Str. Tel.: +7 (843) 237-36-18. E-mail: yakupovasp@mail.ru.


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