Disseminated intravascular blood coagulation syndrome in case of COVID-19 infection


DOI: https://dx.doi.org/10.18565/therapy.2020.5.25-34

Vorobyev P.A., Momot A.P., Zaitsev A.A., Elykomov V.A., Sychev D.A., Krasnova L.S., Vorobyev A.P., Vasiliev S.A., Vorobyeva N.A.

1) Moscow City Scientific Society of Internal Medicine; 2) Medical Institute of continuing education of Moscow State University of Food Production; 3) Altai branch of National Medical Research Center of Hematology of the Ministry of Healthcare of Russia, Barnaul; 4) Altai State Medical University of the Ministry of Healthcare of Russia, Barnaul; 5) Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia, Moscow; 6) I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University); 7) National Medical Research Center of Hematology of the Ministry of Healthcare of Russia, Moscow; 8) Northern branch of the National Medical Research Center of Hematology of the Ministry of Healthcare of Russia, Arkhangelsk; 9) Northern State Medical University of the Ministry of Healthcare of Russia, Arkhangelsk
Current study provides a methodology for the development of scientifically based recommendations for the diagnosis and treatment of disseminated intravascular coagulation syndrome as the basis for the pathogenesis of fatal complications development in case of various respiratory viral infections, and primarily in infection caused by a new type of coronavirus SARS19. Approaches to the diagnosis and complex treatment of this condition using anticoagulants, fresh-frozen plasma, and plasmapheresis are proposed.
Keywords: disseminated intravascular coagulation, new coronavirus infection, COVID-19, anticoagulants, fresh-frozen plasma, plasmapheresis
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Literature


  1. Рекомендации МГНОТ по диагностике и интенсивной терапии синдрома диссеминированного внутрисосудистого свертывания крови при вирусном поражении легких. Под ред. проф. Воробьева П.А. и проф. Елыкомова В.А. Проблемы стандартизации в здравоохранении. 2020; 5–6. [MCSSP guidelines for the diagnosis and intensive care of disseminated intravascular coagulation syndrome in viral lung disease. Ed. by prof. Vorobyov P.A. and prof. Elykomov V.A. Problemy standartizatsii v zdravookhranenii. 2020; 5–6 (In Russ.)]. doi: https://doi.org/10.26347/1607-2502202005-06099-111.

  2. Varga Z., Flammer A.J., Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020; 395(10234): 1417–18. doi: 10.1016/S0140-6736(20)30937-5.

  3. Заратьянц О.В., Самсонова М.В., Михалева Л.М. с соавт. Патологическая анатомия COVID-19. Атлас. Под общ. ред. О.В. Заратьянца. Москва: ДЗМ. 2020. Электронное издание. URL: https://mosgorzdrav.ru/uploads/imperavi/ru-RU/patanatomiya_covid19_fullv2_compressed.pdf (дата обращения – 19.07.2020). [Zaratiyants O.V., Samsonova M.V., Mikhaleva L.M. et al. Pathological anatomy of COVID-19. Medical atlas. Ed. by Zaratiyants O.V. Moscow: Moscow Department of Healthcare. 2020. Electronic edition. URL: https://mosgorzdrav.ru/uploads/imperavi/ru-RU/patanatomiya_covid19_fullv2_compressed.pdf (date of access – 19.07.2020) (In Russ.)].

  4. Ackermann M., Verleden S.E., Kuehnel M. et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. N Ingl J Med. 2020; 383(2): 120–28. doi: 10.1056/NEJMoa2015432.

  5. Временные методические рекомендации – профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 6 (28.04.2020). Министерство здравоохранения Российской Федерации. Электронное издание. URL: https://static-1.rosminzdrav.ru/system/attachments/attaches/000/050/116/original/28042020_МR_COVID-19_v6.pdf (дата обращения – 19.07.2020). [Temporary guidelines – prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version 6 (28.04.2020). Ministry of Healthcare of the Russian Federation. Electronic edition. URL: https://static-1.rosminzdrav.ru/system/attachments/attaches/000/050/116/original/28042020_МR_COVID-19_v6.pdf (date of access – 19.07.2020) (In Russ.)].

  6. Delirium, rare brain inflammation and stroke linked to COVID-19. University College London. URL: https://www.ucl.ac.uk/news/2020/jul/delirium-rare-brain-inflammation-and-stroke-linked-covid-19 (date of access – 19.07.2020).

  7. Politi L.S., Salsano E., Grimaldi M. Magnetic resonance imaging alteration of the brain in a patient with coronavirus disease 2019 (COVID-19) and anosmia. JAMA Neurol. 2020 May 29. doi: 10.1001/jamaneurol.2020.2125. Online ahead of print.

  8. Testa S., Prandoni P., Paoletti O. et al. Direct oral anticoagulant plasma levels’ striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: The Cremona experience. J Thromb Haemost. 2020; 18(6): 1320–23. doi: 10.1111/jth.14871

  9. Paranjpe I., Fuster V., Lala A. et al. Association of treatment dose anticoagulation with in-hospital survival among hospitalized patients with COVID-19. J Am Coll Cardiol. 2020; 76(1): 122–24. doi: 10.1016/j.jacc.2020.05.001.

  10. Coronavirus disease (COVID-19): Symptoms and treatment. The official website of the Government of Canada. URL: https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/symptoms.html (date of access –19.07.2020).

  11. U.S. Department of Health & Human Services, Centers for Disease Control and Prevention 2019 Novel Coronavirus. URL: https://www.cdc.gov/coronavirus/2019-ncov/index.html (date of access –19.07.2020).

  12. Временные методические рекомендации – профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 7 (03.06.2020). Министерство здравоохранения Российской Федерации. Электронное издание. URL: https://static-0.rosminzdrav.ru/system/attachments/attaches/000/050/584/original/03062020_МR_COVID-19_v7.pdf (дата обращения – 19.07.2020). [Temporary guidelines – prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version 7 (03.06.2020). Ministry of Healthcare of the Russian Federation. Electronic edition. URL: https://static-0.rosminzdrav.ru/system/attachments/attaches/000/050/584/original/03062020_МR_COVID-19_v7.pdf (date of access – 19.07.2020) (In Russ.)].

  13. Auyeung T.W., Lee J.S.W., Lai W.K. et al. The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study. J Infect. 2005; 51(2): 98–102. doi: 10.1016/j.jinf.2004.09.008.

  14. Глюкокортикостероиды при COVID-19. Наш опыт и новый взгляд на ведение больных. Информационное письмо МАСРМ. URL: http:// http://cough-conf.ru/uploads/20200512/glyukokortikosteroidy.novyj-vzglyad-na-lechenie-kovid.pdf (дата обращения – 19.07.2020). [Glucocorticosteroids for COVID-19 treatment: Our experience and a new perspective on patient management. IASRM information mail. URL: http:// http://cough-conf.ru/uploads/20200512/glyukokortikosteroidy.novyj-vzglyad-na-lechenie-kovid.pdf (date of access – 19.07.2020) (In Russ.)].

  15. Зайцев А.А., Чернов С.А., Стец В.В. с соавт. Алгоритмы ведения пациентов с новой коронавирусной инфекцией COVID-19 в стационаре. Методические рекомендации. М.: ГВКГ им. Н.Н. Бурденко. 2020; 16 с. URL: www.gvkg.ru. [Zaytsev A.A., Chernov S.A., Stets V.V. et al. Algorithms for managing patients with new coronavirus infection COVID-19 in a hospital. Guidelines. M.: Main Military Clinical Hospital named after Burdenko N.N. 2020; 16 p. URL: www.gvkg.ru (In Russ.)].

  16. Adeli S.H., Asghari A., Tabarraii R. et al. Therapeutic plasma exchange as a rescue therapy in patients with coronavirus disease 2019: a case series. Pol Arch Intern Med. 2020; 130: 455–58. doi: 10.20452/pamw.15340

  17. Kawashima H., Togashi T., Yamanaka G. et al. Efficacy of plasma exchange and methylprednisolone pulse therapy on influenza-associated encephalopathy. J Infect. 2005; 51(2): E53–6. doi: 10.1016/j.jinf.2004.08.017.

  18. Авдеев С.Н., Андреенко А.А., Арсентьев Л.В. с соавт. Методические рекомендации «Анестезиолого-реанимационное обеспечение пациентов с новой коронавирусной инфекцией COVID-19». 2020. Электронное издание. URL: https://edu.rosminzdrav.ru/fileadmin/user_upload/specialists/COVID-19/dop-materials/11_05_2020/Metreki_FAR.pdf (дата обращения – 19.07.2020). [Avdeev S.N., Andreenko A.A., Arsentiev L.V. et al. Guidelines «Anesthetic and resuscitation services for patients with the new coronavirus infection COVID-19». 2020. Electronic edition. URL: https://edu.rosminzdrav.ru/fileadmin/user_upload/specialists/COVID-19/dop-materials/11_05_2020/Metreki_FAR.pdf (date of access – 19.07.2020) (In Russ.)].


About the Autors

Pavel A. Vorobyev, MD, professor, Chairman of the board of the Moscow City Scientific Society of internal medicine, head of the Department of hematology and geriatrics of the Medical Institute of Continuing Education of Moscow State University Of Food Production. Address: 121614, Moscow, 47 Krylatskie kholmy Str. Tel.: +7 (495) 225-83-74. E-mail: paanvo@me.com ORCID: 0000-0003-2500-1555
Andrey P. Momot, MD, professor, director of the Altai branch of National Medical Research Center of Hematology of the Ministry of Healthcare of Russia. Address: 656044, Barnaul, 1 Lyapidevsky Str. Tel.: +7 (495) 612-45-51.
E-mail: xyzan@yandex.ru. ORCID: 0000-0002-8413-5484
Andrey A. Zaitsev, MD, professor, chief pulmonologist of the Ministry of Defense of the Russian Federation, professor of the Department of hematology and geriatrics of Moscow State University of Food Production. Address: 125080, Moscow, 11 Volokolamskoe Highway. Tel.: +7 (499) 750-01-11. E-mail: a-zaicev@yandex.ru ORCID: 0000-0002-0934-7313
Valery A. Elykomov, MD, professor, head of the Department of therapy of Altai State Medical University of the Ministry of Healthcare of Russia, Deputy of the State Duma of the 7th convocation. Address: 656044, Barnaul, 1 Lyapidevsky Str. Tel.: +7 (495) 612-45-51. E-mail: realzel@gmail.com. Scopus author Id: 6507040972
Dmitry A. Sychev, MD, professor, corresponding member of RAS, rector of Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia. Address: 125993, Moscow, 2/1 Barrikadnaya Str., build 1. 1. Tel.: +7 (495) 680-05-99. E-mail: rmapo@rmapo.ru. ORCID: 0000-0002-4496-3680
Lyubov S. Krasnova, PhD, associate professor of the Department of general medical practice of I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. E-mail: aelita8@yandex.ru. ORCID: 0000-0002-8102-3989
Andrey P. Vorobyev, PhD, assistant of the Department of therapy of the Medical Institute of Continuing Education of Moscow State University of Food Production. Address: 125080, Moscow, 11 Volokolamskoe Highway. Tel.: +7 (499) 750-01-11. E-mail: andvorob@gmail.com. ORCID: 0000-0003-3851-8473
Sergey A. Vasiliev, MD, professor, leading researcher of National Medical Research Center of Hematology of the Ministry of Healthcare of Russia. Address: 125167, Moscow, 4 Novy Zykovsky Lane. Tel.: +7 (495) 612-21-23.
E-mail: vasiliev.s@blood.ru
Nadezhda A. Vorobyeva, MD, professor, director of the Northern branch of National Medical Research Center of Hematology of the Ministry of Healthcare of Russia, head of the Department of clinical pharmacology and pharmacotherapy of the Northern State Medical University of the Ministry of Healthcare of Russia. Address: 163000, Arkhangelsk, 51 Troitsky Prospect. Tel.: +7 (8182) 28-57-91. E-mail: nadejdav0@gmail.com. Scopus Author ID: 55532075000

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