Prognostic potential of some classes of lipids in primary osteoarthritis patients


DOI: https://dx.doi.org/10.18565/therapy.2021.2.100-104

Zwinger S.M., Karachenova A.M., Govorin A.V.

Chita State Medical Academy of the Ministry of Healthcare of Russia
Abstract. The purpose of the study was to estimate the content of some classes of lipids in blood serum and their prognostic potential in the development of early atherosclerosis (AS) in primary osteoarthritis (OA) patients.
Material and methods. 184 patients with primary OA were included in the study. Indicators of lipid spectrum and apolipoproteins (Apo) metabolism were studied.
Results. It was revealed that the levels of low density lipoprotein cholesterol and triglycerides (TG) were significantly higher comparatively to control group in all patients with OA, and reached maximum values when OA and AS were combined. Significant differences in the TG content were recorded in patients with OA, depending on the intima-media complex (IMC) thickness. A strong positive correlation between the IMC thickness and the value of the atherogenic coefficient was established, as well as a negative correlation between the average strength and the level of high density lipoprotein cholesterol. The concentrations of ApoB100, ApoCII, and ApoE were higher, and ApoA1 was lower in all patients with OA comparatively with those in the control group. A strong positive relationship between the IMC thickness and the ApoB100/ApoAI index was fixed.
Conclusion. Obtained information could be taken into account for dispensary observation performance of OA in order to timely identify preclinical asymptomatic stages of atherosclerosis in this category of patients.
Keywords: остеоартрит, атеросклероз, липидный профиль, диспансерное наблюдение
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Literature


  1. Симакова Е.С., Сивордова Л.Е., Романов А.И. с соавт. Клинико-патогенетическое значение дислипидемии при остеоартрозе. Кремлевская медицина. Клинический вестник. 2013; 4: 74–77. [Simakova E.S., Sivordova L.E., Romanov A.I. et al. Clinical and pathogenetic significance of dyslipidemia in osteoarthritis. Kremlevskaya meditsina = The Kremlin medicine. Clinical bulletin. 2013; 4: 74–77 (In Russ.)].

  2. Kaneva A.M., Bojko E.R. Lipid exchange indexes: information capacity and clinical meaning in the course of valuation of atherogenicity of lipemic index of blood. Medical academic journal. 2017; 17(1): 41–50. doi: 10.17816/maj17141-50.

  3. Martocchia A., Toussan L., Stefanelli M. et al. Association of severity of osteoarthritis and carotid atherosclerosis in patients with metabolic syndrome. Rheumatology. 2011; 1: 105. doi: 10.4172/2161-1149.1000105.

  4. Кабалык М.А., Невзорова В.А. Дислипидемия и атеросклероз в патогенезе остеоартрита. Медицинский альманах. 2018; 5: 220–224. [Каbalyk M.A., Nevzorova V.A. Dyslipidemia and atherosclerosis in the pathogenesis of osteoarthritis. Meditsinskiy al'manakh = Medical almanac. 2018; 5: 220–224 (In Russ.)]. Doi: https://dx.doi.org/10.21145/2499-9954-2018-5-220-224.

  5. Лапшина С.А., Фейсханова Л.И., Нурмиева А.Р., Садриев К.А. Остеоартрит у пациентов с компонентами метаболического синдрома. Терапия. 2019; 8: 52–58. [Lapshina S.A., Feyskhanova L.I., Nurmieva A.R., Sadriev K.A. Osteoarthritis in patients with metabolic syndrome components. Terapiya = Therapy. 2019; 8: 52–58 (In Russ.)]. doi: https://dx.doi.org/10.18565/therapy.2019.8.52-58.

  6. Hoeven T.A., Kavousi M., Clockaerts S. Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study. Ann Rheum Dis. 2013; 72(5): 646–51. doi: 10.1136/annrheumdis-2011-201178.

  7. Villaivilla A., Gomez R., Herrero-Beaumont G. Lipid transport and metabolism in healthy and osteoarthritic cartilage. Int J Mol Sci. 2013; 14(10): 20793–808. doi: 10.3390/ijms141020793.

  8. Канева А.М., Бойко Е.Р. Индексы липидного обмена: информативность и клиническое значение при оценке атерогенности липидного профиля крови. Медицинский академический журнал. 2017; 1: 41–50. [Kaneva A.M., Boyko E.R. Lipid exchange indexes: information capacity and clinical meaning in the course of valuation of atherogenicity of lipemic index of blood. Meditsinskiy akademicheskiy zhurnal = Medical academic journal. 2017; 1: 41–50 (In Russ.). doi: https://dx.doi.org/10.17816/MAJ17141-50.

  9. Симакова Е.С., Заводовский Б.В., Сивордова Л.Е. с соавт. Прогностическое значение нарушений липидного обмена у больных остеоартрозом. Сибирский медицинский журнал. 2013: 2: 44–47. [Simakova E.S., Zavodosky B.V., Sivordova L.E. et al. Prognostic significance of lipid disorders in osteoarthritis patients. Sibirskiy meditsinskiy zhurnal = Siberian medical journal. 2013: 2: 44–47 (In Russ.)].

  10. Liu W., Balu N., Canton G. et al. Understanding atherosclerosis through an osteoarthritis data set. Arterioscler Thromb Vasc Biol. 2019; 39(6): 1018–25. doi: 10.1161/ATVBAHA.119.312513..

  11. Алексенко Е.Ю., Говорин А.В., Цвингер С.М. Медиаторы воспаления у больных остеоартрозом в сочетании с артериальной гипертензией. Медицинская иммунология. 2010; 4–5: 429–432. [Aleksenko E.U., Govorin A.V., Tsvinger S.M. Inflammatory markers in patients with osteoarthritis and arterial hypertension. Meditsinskaya immunologiya = Medical immunology. 2010; 4–5: 429–432 (In Russ.)].

  12. Пальгуева А.Ю., Литвяков А.М. Ревматоидный артрит и атеросклероз: фокус на хроническую инфекцию. Обзор литературы. Вестник Витебского государственного медицинского университета. 2020: 3: 14–22. [Palguyeva H.Y., Litvyakov A.M. Rheumatic arthritis and atherosclerosis: focus on persistent infection. Literature review. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta = Vitebsk State Medical University bulletin. 2020: 3: 14–22 (In Russ.)]. doi: https://dx.doi.org/10.22263/2312-4156.2020.3.14.

  13. Bierma-Zeinstra S.M.A., Waarsing J.H. The role of atherosclerosis in osteoarthritis. Best Pract Res Clin Rheumatol. 2017; 31(5): 613–33. doi: 10.1016/j.berh.2018.08.006.

  14. Трухан Д.И., Иванова Д.С., Белус К.Д. Ревматоидный артрит и традиционные кардиоваскулярные факторы риска: актуальные аспекты реальной клинической практики. Consilium Medicum. 2020; 1: 19–25. [Trukhan D.I., Ivanova D.S., Belus K.D. Rheumatoid arthritis and traditional cardiovascular risk factors: actual aspects of real clinical practice. Consilium Medicum. 2020; 1: 19–25 (In Russ.)]. doi: https://dx.doi.org/10.26442/20751753.2020.1.200052.

  15. Zeynep O., Cumali E., Mustafa C. с соавт. Новые данные о связи ревматоидного артрита и атеросклероза. Атеросклероз и дислипидемии. 2011; 4: 4–11. [Zeynep O., Cumali E., Mustafa C. et al. An update on the relationships between rheumatoid arthritis and atherosclerosis. Atheroscleroz i dislipidemiya = Atherosclerosis and dyslipidemias. 2011; 4: 4–11 (In Russ.)].


About the Autors

Svetlana M. Zwinger, PhD., associate professor of the Department of outpatient therapy with a course of medical rehabilitation, Chita State Medical Academy of the Ministry of Healthcare of Russia. Address: 672000, Chita, 39a Gorkogo Str. Tel.: +7 (914) 490-40-04. E-mail: tsvinger_s_m@mail.ru. ORCID: 0000-0003-2082-9839
Anastasia M. Karachenova, assistant of the Department of outpatient therapy with a course of medical rehabilitation, Chita State Medical Academy of the Ministry of Healthcare of Russia. Address: 672000, Chita, 39a Gorkogo Str.
E-mail: b_a_m_2010@mail.ru. ORCID: 0000-0003-1704-490
Anatoly V. Govorin, MD, professor, head of the Department of faculty therapy, Chita State Medical Academy of the Ministry of Healthcare of Russia. Address: 672000, Chita, 39a Gorkogo Str. E-mail: rector-chgma@mail.ru.
ORCID: 0000-0001-7586-6595

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