Secondary prevention of ischemic heart disease and PCSK9 inhibitors


DOI: https://dx.doi.org/10.18565/therapy.2021.2.105-111

Kuznetzov A.A., Mal G.S.

1) Moscow Regional Hospital named after prof. Rozanov V.N., Moscow region, Pushkino; 2) Kursk State Medical University of the Ministry of Healthcare of Russia
Abstract. Ischemic heart disease is the leading cause of death for many years throughout the world. Use of inhibitors of cholesterol synthesis in the liver - statins was the leading method of secondary hypercholesterolemia prevention for a long time. However, on the phobe of their intake only 70% of patients got the target level of atherogenic lipids. Therefore, new and more effective lipid-lowering drugs were searched for many years. In 2015, for the first time, PCSK9 plasma protein inhibitors were approved for clinical use. Their use allows to achieve the target level of lipid parameters in more than 90% of patients.
Keywords: PCSK9 inhibitors, ischemic heart disease, atherosclerosis, alirocumab, evalocumab
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About the Autors

Andrey A. Kuznetzov, cardiologist of Moscow Regional Hospital named after prof. Rozanov V.N. Address: 141206, Moscow region, Pushkino, 35 Aviationnaya Str. Tel.: +7 (977) 684-27-15. E-mail: dr.cardiologist.kuznetsov@yandex.ru
Galina S. Mal, MD, professor, head of the Department of pharmacology, Kursk State Medical University of the Ministry of Healthcare of Russia. Address: 305003, Kursk, 3 K. Marx Str. Tel.: +7 (960) 676-16-98. E-mail: mgalina.2013@mail.ru

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