Etiology of severe acute respiratory viral infection during the epidemic seasons 2015–2020


DOI: https://dx.doi.org/10.18565/therapy.2021.4.7-17

Danilenko D.M., Sominina A.A., Komissarov A.B., Pisareva M.M., Stolyarov K.A., Musaeva T.D., Eder V., Bakaev M.I., Komissarova K.S., Ivanova A.A., Fadeev A.V., Smorodintseva E.A., Rozhkova E.G., Guzhov D.A., Venev E.V., Dondurey E.A., Afanasieva O.I., Obraztsova E.V., Timonina V.S., Golovacheva E.G., Kurskaya O.G., Shestopalov A.M., Alimov A.V., Lelenkova E.V., Lioznov D.A.

1) A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, St. Petersburg; 2) S.P. Botkin Clinical Infectious Diseases Hospital, St. Petersburg; 3) N.F. Filatov Children’s City Clinical Hospital No. 5, St. Petersburg; 4) St. Olga Children’s City Hospital, St. Petersburg; 5) Federal Research Center for Fundamental and Translational Medicine, Novosibirsk; 6) Yekaterinburg Research Institute of Viral Infections of SSC VB «Vector» of Rospotrebnadzor; 7) Acad. I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia
Abstract. The aim of the study was to establish the contribution of separate etiological agents to the development of severe forms of acute respiratory viral infections (SARI) registered in hospital conditions depending on the age of patients during several consecutive epidemic seasons.
Material and methods. A retrospective analysis of the etiology of SARI cases was carried out in 14 414 hospitalized patients included in the study on hospital surveillance of influenza in the 2015–2020 seasons, for which a laboratory decoding of ARVI etiology was obtained.
Results. The contribution of various influenza viruses to the development of SARI was determined, and the leading role of influenza A (H1N1) pdm09 viruses as a reason point for hospitalization in the intensive care unit (ICU) was shown. The role of viruses of non- influenza etiology in children’s morbidity has been demonstrated, including the importance of the respiratory syncytial virus as the leading pathogen in acute respiratory viral infections structure in young children, leading to the development of SARI with subsequent ICU hospitalization. In addition, the contribution of rhinovirus infection to the development of ARVI in patients of all age groups hospitalized with SARI of non-influenza etiology was determined.
Conclusion. Current study demonstrates the importance of continuing research in the field of hospital monitoring for influenza and other acute respiratory viral infections, especially in conditions of active circulation of the causative agent of new COVID-19 coronaviral infection.
Keywords: virus of influenza, etiology of acute respiratory infections, severe acute respiratory infection, respiratory syncytial virus
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About the Autors

Daria M. Danilenko, candidate of biological sciences, Deputy Director for scientific work, head of the Department of etiology and epidemiology, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-25. E-mail: daria.danilenko@influenza.spb.ru. ORCID: 0000-0001-6174-0836
Anna A. Sominina, MD, professor, head of the laboratory for the study of risk factors for influenza and acute respiratory viral infections, chief researcher of A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-29. E-mail: anna.sominina@influenza.spb.ru. ORCID: 0000-0001-9671-0629
Andrey B. Komissarov, head of the laboratory of molecular virology, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-20. E-mail: andrey.komissarov@influenza.spb.ru.com. ORCID: 0000-0003-1733-1255
Maria M. Pisareva, candidate of biological sciences, leading researcher of the laboratory of molecular virology, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-20. E-mail: maria.pisareva@influenza.spb.ru. ORCID: 0000-0002-1499-9957
Kirill A. Stolyarov, leading programmer of the laboratory of epidemiology of influenza and acute respiratory disorders, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-25. E-mail: kirill@influenza.spb.ru. ORCID: 0000-0002-1765-2799
Tamila D. Musaeva, junior researcher of the laboratory of molecular virology, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-20. E-mail: tamila.musaeva@influenza.spb.ru. ORCID: 0000-0002-3050-1936
Veronika Eder, senior researcher of the laboratory of molecular virology, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-20. E-mail: veronika.eder@influenza.spb.ru
Mikhail I. Bakaev, junior researcher of the laboratory of molecular virology A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-20. E-mail: mibakaev18@gmail.com
Ksenia S. Komissarova, junior researcher of the laboratory of molecular virology, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-20. E-mail: ksenia.komissarova@influenza.spb.ru. ORCID: 0000-0002-1465-5548
Anna A. Ivanova, junior researcher of the laboratory of molecular virology, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-20. E-mail: anna.ivanova@influenza.spb.ru. ORCID: 0000-0002-3495-4393
Artem V. Fadeev, researcher of the laboratory of molecular virology, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-20. E-mail: artem.fadeev@influenza.spb.ru. ORCID: 0000-0003-3558-3261
Elizaveta A. Smorodintseva, leading researcher of the laboratory of epidemiology of influenza and acute respiratory diseases, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-25. E-mail: liza.smorodintseva@influenza.spb.ru. ORCID: 0000-0002-5002-0523
Elena G. Rozhkova, PhD., leading researcher, Department of experimental and clinical research, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-25. E-mail: elena.rozhkova@influenza.spb.ru
Dmitry A. Guzhov, full-time postgraduate student of A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, infectious disease physician of S.P. Botkin Clinical Infectious Diseases Hospital. Address: 191024, St. Petersburg, 3 Mirgorodskaya Str. Tel.: +7 (812) 409-78-87. E-mail: dimas1992@list.ru
Evgeny V. Venev, full-time postgraduate student, senior lecturer, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, infectious disease physician of S.P. Botkin Clinical Infectious Diseases Hospital. Address: 191024, St. Petersburg, 49 Piskarevsky pr. Str. Tel.: +7 (812) 409-78-87. E-mail: imberbis@gmail.com
Elena A. Dondurei, PhD., senior researcher of the Department of respiratory viral infections in children, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, head of the Department – infectious disease doctor of the infectious boxed Department No. 10, N.F. Filatov Children’s City Clinical Hospital No. 5, Chief freelance specialist on infectious diseases in children of the Health Committee of the Government of St. Petersburg. Address: 192289, St. Petersburg, 134 Bukharestskaya Str. Tel.: +7 (812) 400-04-10. E-mail: elena.dondurei@influenza.spb.ru
Olga I. Afanasyeva, MD, head of the Department of respiratory viral infections in children, A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, St. Olga Children’s City Hospital. Address: 194156, St. Petersburg, 2 Zemledeltcheskaya Str. Tel.: +7 (812) 295-69-57. E-mail: olga.afanasieva@influenza.spb.ru. ORCID: 0000-0002-1229-171X
Elena V. Obraztsova, PhD, senior researcher of the Department of respiratory viral infections in children,
A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, N.F. Filatov Children’s City Clinical Hospital No. 5. Address: 192289, St. Petersburg, 134 Bukharestskaya Str. Tel.: +7 (812) 400-04-10. E-mail: elena.obraztsova@influenza.spb.ru
Veronika S. Timonina, neonatologist of A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, St. Olga Children’s City Hospital. Address: 194156, St. Petersburg, 2 Zemledeltcheskaya Str. Tel.: +7 (812) 295-69-57
Ekaterina G. Golovacheva, MD, staff member of the Department of respiratory viral infections in children,
A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, St. Olga Children’s City Hospital. Address: 194156, St. Petersburg, 2 Zemledeltcheskaya Str. Tel.: +7 (812) 295-69-57. E-mail: ekaterina.golovacheva@influenza.spb.ru
Olga G. Kurskaya, PhD, senior researcher of the laboratory for development and testing of pharmaceutical agents, Federal Research Center for Fundamental and Translational Medicine. Address: 630117, Novosibirsk, 2 Timakova Str. Tel.: +7 (383) 335-97-74. E-mail: kurskaya_og@mail.ru. ORCID: 0000-0002-1931-2026
Alexander M. Shestopalov, doctor of biological sciences, professor, head of the Department of experimental modeling and pathogenesis of infectious diseases, Federal Research Center for Fundamental and Translational Medicine. Address: 630117, Novosibirsk, 2 Timakova Str. Tel.: +7 (383) 335-97-74. E-mail: shestopalov2@ngs.ru. ORCID: 0000-0002-1880-8708
Alexander V. Alimov, PhD, Director of Yekaterinburg Research Institute of Viral Infections of SSC VB «Vector» of Rospotrebnadzor, Honored doctor of the Russian Federation. Address: 620030, Yekaterinburg, 23 Letnyja Str. Tel.: +7 (343) 261-99-47. E-mail: alexalimov@yandex.ru. ORCID: 0000-0003-0511-9409
Evgenia V. Lelenkova, epidemiologist of Yekaterinburg Research Institute of Viral Infections of SSC VB «Vector» of Rospotrebnadzor. Address: 620030, Yekaterinburg, 23 Letnyja Str. Tel.: +7 (343) 261-99-47. E-mail: e.lelenkova@inbox.ru. ORCID: 0000-0003-2004-0977
Dmitry A. Lioznov, acting director of A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia, head of the Department of infectious diseases of Acad. I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197376, St. Petersburg, 15/17 Professor Popov Str. Tel.: +7 (812) 499-15-00. E-mail: office@influenza.spb.ru. ORCID: 0000-0003-3643-7354

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