Parameters associated with the presence of significant coronary atherosclerosis


DOI: https://dx.doi.org/10.18565/therapy.2021.5.33-38

Kotova Yu.A., Zuikova A.A., Strakhova N.V., Krasnorutskaya O.N., Esina E.Yu.

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia
Abstract. The aim of the study was to fix clinical features associated with the presence of significant coronary atherosclerosis in patients referred for coronary angiography using factor analysis.
Material and methods. 336 patients with coronary heart disease (CHD) diagnosis took part in the study. CHD presence was confirmed by diagnostic coronary angiography performing according to the Judkins method with Gensini index calculation.
Results. In the group of patients with hemodynamically significant coronary atherosclerosis, the highest values of indicators of oxidative proteins modification (OMP), homocysteine and highly sensitive C-reactive protein (hs-CRP) and the lowest values of heat shock proteins-70 (HSP70) and superoxide dismutase (SOD) activity were found. That indicates the severity of oxidative and cellular stress. According to the results of factor analysis, 6 main factors were identified which explained 75,5% of the total dispersion: endothelial dysfunction factor, constitutional factor, modifiable risk factor, lipid factor, age and prooxidant factor. The first factor turned out to be the most significant. A strong mutual correlation was demonstrated by OMP indicators, homocysteine, SOD, HSP70 and hs-CRP.
Conclusion. Use of factor analysis for obtained multivariate data statistical processing made it possible to identify and study the pathogenetic relationships between the variables, determine the most significant criteria for coronary atherosclerosis diagnosis, and calculate the hypothetical values of the selected cumulative factors individually for each patient.
Keywords: factor analysis, heat shock proteins 70, Gensini index, oxidative modification of proteins, superoxide dismutase, coronary atherosclerosis, homocysteine
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About the Autors

Yulia A. Kotova, PhD, associate professor of the Department of outpatient therapy, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya Str. Tel.: +7 (929) 010-71-07. E-mail: kotova_u@inbox.ru. ORCID: 0000-0003-0236-2411
Anna A. Zuikova, MD, professor, Vice rector for academic affairs, head of the Department of outpatient therapy, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya Str. E-mail: zuikova-terapia23@mail.ru ORCID: 0000-0003-2392-3134
Natalia V. Strakhova, PhD, associate professor, head of educational Department, associate professor of the Department of outpatient therapy, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya Str. Tel.: +7 (920) 423-66-78. E-mail: nvstrahova@gmail.com. ORCID: 0000-0002-8256-885X
Olga N. Krasnorutskaya, MD, associate professor, dean of the Faculty of general medicine, professor of the Department of outpatient therapy, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya Str. Tel.: +7 (980) 552-03-93. E-mail: onkrasnorutckaja@rambler.ru. ORCID: 0000-0003-4796-7334
Elena Yu. Esina, MD, associate professor, professor of the Department of outpatient therapy, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya Str. Tel.: +7 (960) 112-75-22. E-mail: elena.esina62@mail.ru. ORCID: 000-0001-7048-9428

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