Clinical case: interstitial pulmonary fibrosis in systemic sclerosis


DOI: https://dx.doi.org/10.18565/therapy.2021.5.121-126

Konyukova A.K., Pechnikova V.V., Vasyukova O.A., Ananieva L.P., Cherniaev A.L., Samsonova М.V.

1) Research Institute of Human Morphology, Moscow; 2) V.A. Nasonova Research Institute of Rheumatology, Moscow; 3) Research Institute of Pulmonology of FMBA of Russia, Moscow; 4) A.S. Loginov Moscow Clinical Scientific Center of the Department of Healthcare of Moscow
Abstract. The introductory part of the article provides a concise literature review on the etiology, classification, frequency and variants of systemic sclerosis (SSc). The article presents a clinical case of a 78-year-old female patient with a clinical diagnosis of SSc. She was diagnosed with interstitial pulmonary fibrosis in systemic sclerosis based on clinical manifestation, radiological and laboratory findings. The autopsy revealed interstitial pulmonary fibrosis with cellular degeneration. Histological examination demonstrated a combination of gentle collagen fibrosis with honeycombing, nonspecific interstitial pneumonia with elastic tissue, and microscopic features of secondary pulmonary arterial hypertension.
Keywords: systemic sclerosis, pulmonary fibrosis, pulmonary arterial hypertension
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About the Autors

Alexandra K. Konyukova, resident of the Laboratory of clinical morphology, Research Institute of Human Morphology. Address: 117418, Moscow, 3 Tsuryupy Str. E-mail: have.to.study@yandex.ru. ORCID: 0000-0001-5925-5196
Valentina V. Pechnikova, pathologist, junior researcher of the Laboratory of clinical morphology, Research Institute of Human Morphology. Address: 117418, Moscow, 3 Tsuryupy Str. E-mail: valiagtx@yandex.ru. ORCID: 0000-0001-5896-4556
Lidia P. Ananieva, MD, professor, head of the Laboratory of microcirculation and inflammation, V.A. Nasonova Research Institute of Rheumatology. Address: 115522, Moscow, 34А Kashirskoe Highway. E-mail: lpana@yandex.ru. ORCID: 0000-0002-6426-3248
Olesya A. Vasyukov, junior researcher of the Laboratory of clinical morphology, Research Institute of Human Morphology. Address: 117418, Moscow, 3 Tsuryupy Str. E-mail: o.vas.93@gmail. ORCID: 0000-0001-6068-7009
Andrey L. Chernyaev, MD, professor, head of the Department of fundamental pulmonology, Research Institute of Pulmonology of FMBA of Russia, leading researcher of the Laboratory of clinical morphology, Research Institute of Human Morphology. Address: 115682, Moscow, 28 Orekhovy Boulevard. E-mail: cheral12@gmail.com. ORCID: 0000-0003-0973-9250
Maria V. Samsonova, MD, head of the Laboratory of pathological anatomy, Research Institute of Pulmonology of FMBA of Russia, senior researcher of A.S. Loginov Moscow Clinical Scientific Center of the Department of Healthcare of Moscow. Address: 115682, Moscow, 28 Orekhovy Boulevard. E-mail: sama-ry@mail.ru ORCID:0000-0001-8170-1260


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