Abstract. The aim of the study was to estimate the frequency of occurrence and clinical and nosological spectrum of musculoskeletal synovial joint manifestations and dysplastic pathology of the musculoskeletal system in young-age persons with joint hypermobility syndrome (JHMS).
Material and methods. Clinical, radiological and X-ray functional studies of the orthopedic status were carried out with the assessment of musculoskeletal dysplastic signs and orthopedic pathology at the moment of examination and in anamnisis of 214 JHMS patients from 18 to 34 years old.
Results. The peculiarities of osteoarticular and periarticular manifestations of connective tissue dysplasia in JHMS were fixed and studied. Multiple, polyfocal and combined skeletal dysplasias in the phenotype of hypermobile patients were detailized. The frequency of occurrence and nosological characteristics of postural disorders, chest and spine deformations, qualitative and formative vertebrae abnormities, orthopedic pathology of the feet and hip joints were determined.
Conclusion. The prevalence and wide clinical spectrum of skeletal dysplasias and orthopedic pathology in hypermobile syndrome determines the need for specialized diagnostic measures and active treatment and prophylactic strategies use all together with rational kinesiological and physiotherapeutic aids and orthotics.

Keywords: joint hypermobility syndrome, connective tissue dysplasia, musculoskeletal dysplasia