Thrombotic complications in patients with liver cirrosis: current state of the problem


DOI: https://dx.doi.org/10.18565/therapy.2021.7.112-117

Osadchuk A.M., Osadchuk M.M., Zolotovskaya I.A.

1) Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia, Moscow; 2) Medical University «Reaviz», Samara; 3) Samara State Medical University of the Ministry of Healthcare of Russia
Abstract. The purpose of this review was to provide an update on the epidemiology, risk factors, and treatment of thrombotic complications in patients with cirrhosis. It has been shown that liver cirrhosis significantly increases the risk of various thrombotic complications and cardiomyopathy associated with the development of atrial fibrillation. On the other hand, thrombosis of the visceral veins: portal vein thrombosis, splenic and superior mesenteric veins cause CP decompensation. There is evidence that the use of anticoagulant therapy in patients with atrial fibrillation and liver cirrhosis increases the overall mortality of such patients, compared with those who do not receive such therapy. All this leads to significant difficulties in the treatment of patients. Currently, it is proved that anticoagulant therapy in patients with thrombosis of internal organs against the background of liver cirrhosis should be carried out for at least 6 months, and in case of relapses, for life. At the same time, the choice of anticoagulant therapy among patients with liver cirrhosis is not always unambiguous, which requires further investigation of the existing problem.
Keywords: liver cirrhosis, anticoagulant therapy, atrial fibrillation, thrombosis
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About the Autors

Alexey M. Osadchuk, MD, professor, professor of the Department of gastroenterology, Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia. Address: 123242, Moscow, 2/1 build. 1 Barrikadnaya Str. Tel.: +7 (927) 606-09-40. E-mail: a.m.osadchuk2020@mail.ru. eLibrary SPIN: 9455-3982, ID 651113. ORCID: 0000-0002-8488-9235. Web of Science: Р – 9213-2015. Scopus ID: 24576966600
Maxim M. Osadchuk, PhD, associate professor, associate professor of the Department of clinical medicine, Medical University «Reaviz». Address: 443001, Samara, 227 Chapaevskaya Str. Tel.: +7 (985) 444-14-11. E-mail: osadchuk_83@bk.ru. eLibrary SPIN: 3373-5500, ID 790039. ORCID: 0000-0002-8417-5849
Irina A. Zolotovskaya, MD, professor of the Department of hospital therapy with courses of polyclinic therapy and transfusiology, Samara State Medical University of the Ministry of Healthcare of Russia. Address: 443099, Samara, 89 Chapaevskaya Str. Tel.: +7 (927) 768-78-94. E-mail: zolotovskay@list.ru. eLibrary SPIN: 8824-9668. Scopus ID: 56560260700. ORCID: 0000-0002-0555-4016

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