Analysis of polymorphism rs6737848 of SOCS5 gene with bronchial asthma


DOI: https://dx.doi.org/10.18565/therapy.2021.9.51-56

Averyanov A.B., Cherkashina I.I., Nikulina S.Yu., Maksimov V.N.

1) Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russia; 2) Research Institute of Therapy and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Abstract. For many years, the study of polymorphisms of a large number of genes has continued in the hope of better understanding the bronchial asthma (BA) development mechanisms.
The aim is to study the association of single nucleotide polymorphism of SOCS5 rs6737848 gene in patients with allergic BA.
Material and methods. The objects of the study were 179 patients with a confirmed diagnosis of allergic BA. The control group consisted of practically healthy individuals (n=217). Examination capacity included the study of anamnesis, an objective examination, external respiration function study, an allergological examination, laboratory and instrumental examination methods, and DNA probe assay.
Results. As a result of the study, the data on the distribution of genotypes and alleles of polymorphism rs6737848 of the SOCS5 gene in patients with allergic BA living in Krasnoyarsk were obtained for the first time. Statistically significant differences in the distribution of CC genotype and C allele of the SOCS5 gene (rs6737848) between allergic BA patients and the control group are shown. The entire sampling of allergic BA patients was characterized by a predominance of the CC genotype and C allele and a decrease in the number of carriers of CG genotype and G allele rs6737848 of the SOCS5 gene. Also, a statistically significant predominance of the number of carriers of CC genotype and C allele among females with allergic BA and in the sample of patients with mild allergic BA was fixed.
Conclusion. The obtained data indicate a possible significant influence of CC genotype and C allele rs6737848 of the SOCS5 gene at the development of allergic BA. At the same time, the CG genotype and 9G allele of the SOCS5 gene have a conditionally protective effect concerning allergic BA.
Keywords: rs6737848 of the SOCS5 gene, single nucleotide gene polymorphism, severity of the disease, bronchial asthma
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About the Autors

Anatoly B. Averyanov, assistant of the Department of faculty therapy with the course of FPE, Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str. Tel.: +7 (913) 512-98-46. E-mail: Averyanov_a007@mail.ru. ORCID: 0000-0002-9944-6568
Irina I. Cherkashina, MD, professor of the Department of faculty therapy with a course of FPE, Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str. Tel.: +7 (902) 991-74-29. E-mail: Сherkashina@list.ru. ORCID: 0000-0003-3825-3946
Svetlana Yu. Nikulina, MD, professor, head of the Department of faculty therapy with a course of FPE, Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russia. Address: 660022, Krasnoyarsk, 1 Partizana Zheleznyaka Str. Tel.: +7 (908) 212-53-79. E-mail: nicoulina@mail.ru. ORCID: 0000-0002-6968-7627
Vladimir N. Maksimov, MD, professor, head of the laboratory of molecular genetic studies of therapeutic diseases, Research Institute of Therapy and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences. Address: 630089, Novosibirsk, 175/1 Borisa Bogatkova Str. E-mail: medik11@mail.ru. ORCID: 0000-0002-7165-4496


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