Immunological serum and plasma markers for the diagnosis of inflammatory bowel disease


DOI: https://dx.doi.org/10.18565/therapy.2022.7.44-53

Avalueva E.B., Bakulin I.G., Skalinskaya M.I., Oganezova I.A., Sitkin S.I.

1) I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia, Saint Petersburg; 2) V.A. Almazov National Medical Research Centre of the Ministry of Healthcare of Russia, Saint Petersburg
Abstract. The review presents up-to-date information on serum and plasma immunological markers that may be candidate biomarkers in inflammatory bowel disease (IBD). The review includes information on both well-known and recently discovered IBD candidate biomarkers such as cytokines, chemokines, and non-coding RNAs. Further prospects for the search for biomarkers based on modern molecular technologies are discussed.
Keywords: non-coding RNA, Crohn’s disease, ulcerative colitis, inflammatory bowel disease, chemokines, cytokines, biomarkers
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About the Autors

Elena B. Avalueva, Dr. med. habil., associate professor, professor of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya Str. E-mail: avalueva@mail.ru. ORCID: https://orcid.org/0000-0001-6011-0998
Igor G. Bakulin, Dr. med. habil., professor, head of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya Str. E-mail: igbakulin@yandex.ru. ORCID: https://orcid.org/0000-0002-6151-202
Maria I. Skalinskaya, PhD in Medicine, associate professor, associate professor of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya Str. E-mail: mskalinskaya@yahoo.com. ORCID: https://orcid.org/0000-0003-0769-8176
Inna A. Oganezova, Dr. med. habil., professor, professor of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya Str. E-mail: oganezovaia@gmail.com. ORCID: http://orcid.org/0000-0003-0844-4469
Stanislav I. Sitkin, PhD in Medicine, associate professor, head of the Research group of epigenetics and metagenomics, V.A. Almazov National Medical Research Centre of the Ministry of Healthcare of Russia, associate professor of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya Str. E-mail: sitkins@mail.ru ORCID: http://orcid.org/0000-0003-0331-0963


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