Clinical case: autoimmune hepatitis and primary sclerosing cholangitis overlap syndrome


DOI: https://dx.doi.org/10.18565/therapy.2021.5.127-135

Аlieva А.М., Аlmazova I.I., Brutskaya L.А., Baykova I.Е., Аrakelyan R.А., Salnikova А.I., Ettinger О.А., Kislyakov V.А., Мodestova А.V., Pinchuk Т.V., Tikhomirova А.S., Тотоlyan G.G., Kudaeva М.V., Elmurzaeva D.А., Каdyrova R.К., Rаkhаеv А.М., Valiev R.K., Nikitin I.G.

1) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow; 2) National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of Russia, Moscow; 3) Treatment and Rehabilitation Center of the Ministry of Healthcare of Russia, Moscow; 4) Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labour and Social Protection of Russia, Nalchik; 5) H.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia, Nalchik; 6) A.S. Loginov Moscow Clinical Scientific Center of the Department of Healthcare of Moscow
Abstract. In clinical practice, there are autoimmune overlap syndrome along with standard autoimmune liver diseases – autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC). Overlap syndrome means the presence in one patient of signs characteristic of two autoimmune diseases and, as a rule, is a combination: AIH/PBC, AIH/PSC. According to statistics, in a number of patients with AIH, the cross syndrome occurs with a frequency of no more than 10%. The article presents a case of diagnosis of overlap syndrome in a patient with a combination of AIH and PSC and ulcerative colitis.
Keywords: overlap syndrome, primary sclerosing cholangitis, ulcerative colitis, autoimmune hepatitis
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About the Autors

Amina M. Alieva, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (906) 733-08-31. E-mail: amisha_alieva@mail.ru
Ilda I. Almazova, PhD, doctor-teacher of the Methodological Accreditation and Simulation Center, National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of Russia. Address: 101000, Moscow, 10 Petroverigsky Lane. Tel.: +7 (916) 903-94-83. E-mail: almazovai@rambler.ru
Lyudmila A. Brutskaya, head of the Department of therapy, Treatment and Rehabilitation Center of the Ministry of Healthcare of Russia, inpatient gastroenterologist. Address: 125367, Moscow, 3/5 Ivankovskoe Highway. E-mail: ludmila3to@mail.ru
Irina E. Baykova, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (903) 149-85-53. E-mail: 1498553@mail.ru
Roza A. Arakelyan, student of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (926) 102-48-71. E–mail: elmira/sharm@yandex.ru
Anna I. Salnikova, student of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (926) 102-48-71. E–mail: salnickova5@mail.ru
Olga A. Ettinger, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (916) 136-54-26. E-mail: olga-oett@mail.ru
Vladimir A. Kislyakov, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (916) 628-21-64. E-mail: kvadoctor@mail.ru
Anna V. Modestova, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (916) 175-33-45. E-mail: a.modestowa@yandex.ru
Tatiana V. Pinchuk, PhD, associate professor of the Department of faculty therapy of the Faculty of pediatrics, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (916) 174-78-74. E-mail: doktor2000@inbox.ru
Anna S. Tikhomirova, PhD, assistant of the Department of hospital therapy No. 2 of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow,
1 Ostrovityaninova Str. Tel.: +7 (926) 221-61-15. E-mail: strelka_90@inbox.ru
Gayane G. Totolyan, PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str. Tel.: +7 (916) 248-90-11. E-mail: tgg03@mail.ru
Madina V. Kudaeva, physician for medical and social examination, therapist of the expert staff of Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labour and Social Protection of Russia. Address: 360009, Nalchik, 131В Tarchokova Str. Tel.: +7 (8662) 42-92-49. Е-mail: lyalyusha1974@mail.ru
Dzhannet A. Elmurzaeva, associate professor of the Department of microbiology, virology and immunology,
H.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia. Address: 360004, Nalchik, 173 Chernyshevskogo Str. Tel.: +7 (928) 712-83-19. E-mail: jannet.elmurzaeva@yandex.ru
Raziyat K. Kadyrova, lecturer of the highest category of Medical College, H.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia. Address: 360000, Nalchik, 17 Gorkogo Str.
Tel.: +7 (928) 083-48-66. E-mail: Kadirova47@yandex.ru
Alik M. Rakhaev, MD, head of the expert staff of Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labour and Social Protection of Russia. Address: 360009, Nalchik, 131В Tarchokova Str. E-mail: alikrahaev@yandex.ru
Ramiz K. Valiev, PhD, head of the Department of surgical oncology No.2, A.S. Loginov Moscow Clinical Scientific Center of the Department of Healthcare of Moscow. Address: 111123, Moscow, 86/7 Entuziastov Highway. Tel.: +7 (926) 359-20-60. E-mail: Radiosurgery@bk.ru
Igor G. Nikitin, MD, professor, head of the Department of hospital therapy No. 2 of the Faculty of medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Director of Treatment and Rehabilitation Center of the Ministry of Healthcare of Russia. Address: 117437, Moscow, 1 Ostrovityaninova Str.
Tel.: +7 (916) 616-57-27; 8 (495) 321-55-44. E-mail: igor.nikitin.64@mail.ru. ORCID: 0000-0003-1699-0881


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