Inflammatory bowel diseases and cardiovascular pathology: pathogenetic correlations and age-related peculiarities


DOI: https://dx.doi.org/10.18565/therapy.2022.7.54-58

Khlynova O.V., Stepina E.A., Trapeznikova A.A.

Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia
Abstract. In recent years, an increasing number of studies indicate that patients with inflammatory bowel diseases (IBD) have an increased risk of cardiovascular diseases (CVD). There are several potential links between chronic inflammatory processes associated with IBD and CVD risk, but understanding of their pathogenetic pathways remains unclear. Endothelial dysfunction, high levels of inflammatory mediators and homocysteine, and hypercoagulability condition are considered to be important pathogenetic components. There is a positive correlation between markers of endothelial dysfunction and IBD activity. The aim of the review is to present current data on the risks of cardiovascular diseases in IBD patients. The article discusses the features of etiology and pathogenesis of CVD, taking into account the role of inflammatory factors and the microcirculatory system, and considers age-related peculiarities of IBD and CVD combination.

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About the Autors


Olga V. Khlynova, Dr. med. habil., professor, corresponding member of RAS, head of the Department of hospital therapy, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614000, Perm, 26 Petropavlovskaya Str. E-mail: olgakhlynova@mail.ru. ORCID: https://orcid.org/0000-0003-4860-0112
Ekaterina A. Stepina, PhD in Medicine, associate professor of the Department of hospital therapy, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614000, Perm, 26 Petropavlovskaya Str.
Alena A. Trapeznikova, postgraduate student of the Department of hospital therapy, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614000, Perm, 26 Petropavlovskaya Str. E-mail: trapeznikovagastro@yandex.ru


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