Русский
Cognitive disorders in patients with hypertonic cerebral microangiopathy associated with type 2 diabetes mellitus and COVID-19
DOI: https://dx.doi.org/10.18565/therapy.2023.5.38-44
Semenova T.N., Grigoryeva V.N., Zanozina O.V., Sukhanov S.A.
1) Privolzhsky Research Medical University of the Ministry of Healthcare of Russia, Nizhny Novgorod; 2) N.A. Semashko Nizhny Novgorod Regional Clinical Hospital
The aim: to reveal the impact of type 2 DM and survived COVID-19 at the severity and peculiarities of cognitive disorders in patients with hCMA.
Materials and methods. We examined 33 patients with hCMA, 30 with hCMA and type 2 DM, and 33 with hCMA and type 2 DM who had undergone COVID-19 in the previous year. Clinical and neurological examination, neuroimaging, estimation of cognitive disorders using Frontal dysfunction Battery (FAB) and Montreal cognitive assessment scale (MoCA) were performed.
Results. Patients with a combination of type 2 DM and hCMA differed from patients with isolated hCMA in a greater severity of regulatory dysfunction according to FAB data. Taken place during the previous year, COVID-19 exacerbated cognitive impairment in patients with hCMA in combination with type 2 DM, as evidenced by the analysis of the results of MoCA. 82% of patients with hCMA and type 2 DM who underwent COVID-19 had moderate or severe cognitive disorders according to MoCA data. The increase in cognitive deficit in this category of patients occurred mainly due to the deterioration of visuospatial and mnestic functions.
Conclusion. Type 2 diabetes melitus leads to an increase in regulatory dysfunction in patients with hCMA. COVID-19 contributes to the aggravation of cognitive decline in patients with a combination of hCMA and type 2 DM, negatively affecting primarily the visuospatial and mnestic spheres of cognitive activity.
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About the Autors
Tatyana N. Semenova, PhD in Medical Sciences, assistant at the Department of nervous diseases, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina i Pozharskogo Sq. E-mail: neurotmdoc@gmail.com. ORCID: https://orcid.org/0000-0001-5689-2544
Vera N. Grigorieva, MD, professor, head of the Department of nervous diseases, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina i Pozharskogo Sq. E-mail: vrgr@yandex.ru. ORCID: https://orcid.org/0000-0002-6256-3429
Olga V. Zanozina, MD, associate professor, professor of the Department of hospital therapy and general medical practice named after V.G. Vogralik, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina i Pozharskogo Sq. E-mail: zwx2@mail.ru.
ORCID: https://orcid.org/0000-0003-1830-3600
Sergey A. Sukhanov, postgraduate student of the Department of hospital therapy and general medical practice named after V.G. Vogralik, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina i Pozharskogo Sq. E-mail: sukhanov.aleck@yandex.ru
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