Therapy » Use of systemic corticosteroids in therapy of intestinal inflammatory diseases (Literature review)

Use of systemic corticosteroids in therapy of intestinal inflammatory diseases (Literature review)

DOI: https://dx.doi.org/10.18565/therapy.2023.7.109-119

Abdulganieva D.I., Alekseeva A.A.
1) Kazan State Medical University of the Ministry of Healthcare of Russia; 2) Privolzhsky Research Medical University of the Ministry of Healthcare of the Russia, Nizhny Novgorod

Abstract. High anti-inflammatory activity of systemic corticosteroids (CS) determines their continuing actuality in the treatment of inflammatory bowel diseases (IBD). However, serious adverse events and the development of resistance often neutralize the expected therapeutic effect of these drugs, which requires strict adherence to indications, dosing regimens and duration of their use. At the same time, clear criteria and generally accepted recommendations for the use of CS in versatile clinical practice have not been developed yet. Foreign clinical guidelines for IBD treatment have a wide range of systemic CS doses and various methods for their calculation, based on foreign studies of a fairly low level of evidence, performed quite a long time ago, and also recommended based on a fairly large experience of their use. In Russian guidelines, the proposed doses of systemic CS are higher than in foreign ones, but they are also based on empirical expert assessments. Dose-response studies of CS in patients with IBD have never been made.

Keywords: methods for calculating doses of corticosteroids, effective doses of corticosteroids, mechanism of action of corticosteroids, systemic corticosteroids, inflammatory intestinal disease

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About the Autors

Diana I. Abdulganieva, MD, professor, head of the Department of hospital therapy, Kazan State Medical University of the Ministry of Healthcare of Russia. Address: 420012, Kazan, 49 Butlerova Str.
E-mail: Diana.Abdulganieva@kazangmu.ru ORCID: https://orcid.org/0000-0001-7069-2725
Anastasia A. Alekseeva, 2nd year resident of the Department of hospital therapy and general medical practice named after V.G. Vogralik, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina i Pozharskogo Sq.
E-mail: anastasyalekseeva1998@mail.ru ORCID: https://orcid.org/0000-0001-5161-6436

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