Modern approaches to colorectal cancer screening and prevention


DOI: https://dx.doi.org/10.18565/therapy.2023.8.112-119

Bakulin I.G., Zharkov A.V., Serkova M.Yu., Zhuravleva M.S.

I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia, Saint Petersburg
Abstract. About 2/3 of identified colorectal cancer (CRC) clinical cases in Russia occur in patients with stages III and IV of the disease, which leads to high mortality during the first year after diagnosis verification. Tendency towards an increase in morbidity in persons under 50 years of age determines the necessity of improving methods for timely CRC diagnosis, training medical staff in organizing screening examinations with identification of target groups of patients, and also the necessity of performing work concerning increase of awareness and motivation for population to undergo CRC screening. It is recommended to perform a two-stage screening - estimation of occult blood in the patient’s stool samples by immunochemical method, followed by endoscopic examination in case of a positive result. Screening test must be non-invasive, safe, easily accessible, convenient and inexpensive, and have high sensitivity and specificity. It should be remembered that CRC runs asymptomatically for a long time, and its late diagnosis is associated with the risk of an unfavorable outcome of the disease.
Keywords: immunochemical method for testing stool for occult blood, stool occult blood test, early diagnosis of colorectal cancer, cancer screening, colorectal cancer
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About the Autors

Igor G. Bakulin, MD, professor, head of the Department of propaedeutics of internal diseases, gastroenterology and dietetics named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: igbakulin@yandex.ru
ORCID: https://orcid.org/0000-0002-6151-2021
Alexander V. Zharkov, PhD in Medical Sciences, Chairman of the Healthcare Committee of the Leningrad region, assistant at the Department of propaedeutics of internal diseases, gastroenterology and dietetics named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
ORCID: https://orcid.org/0000-0001-9600-6649-0928
Margarita Yu. Serkova, PhD in Medical Sciences, assistant at the Department of propaedeutics of internal diseases, gastroenterology and dietetics named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: serkova.margarita@yandex.ru
ORCID: https://orcid.org/0000-0001-9600-3131
Maria S. Zhuravleva, PhD in Medical Sciences, associate professor, associate professor of the Department of propaedeutics of internal diseases, gastroenterology and dietetics named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: ms_zhuravleva@mail.ru
ORCID: https://orcid.org/0000-0003-4838-5707


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