Therapy » Paraneoplastic thromboendocarditis: Analysis of three cases in patients with gastric tumor lesion

Paraneoplastic thromboendocarditis: Analysis of three cases in patients with gastric tumor lesion

DOI: https://dx.doi.org/10.18565/therapy.2023.9.158-166

Yagoda A.V., Gladkikh N.N., Koroy P.V., Rybas A.V.
Stavropol State Medical University of the Ministry of Healthcare of Russia

Abstract. Observations of three cases of one of complications of tumor processes – non-bacterial (non-infectious, aseptic) thrombotic endocarditis as paraneoplastic process in patients with adenocarcinoma and gastrointestinal stromal tumor – GIST of stomach wall are presented. Clinical manifestations of autoimmune and coagulopathic syndromes associated with tumors and endocarditis are discussed.

Keywords: paraneoplasia, thrombotic endocarditis, stomach tumors

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Literature

1. Гогин Е.Е., Нешитов С.П., Чуванов М.В., Скалозуб О.И. Сложность распознавания паранеопластических синдромов. Терапевтический архив. 2008; 80(4): 73–76. [Gogin E.E., Neshitov S.P., Chuvanov M.V., Skalozub O.I. Difficulty of recognizing paraneoplastic syndromes. Terapevticheskiy arkhiv = Therapeutic Archive. 2008; 80(4): 73–76 (In Russ.)]. EDN: JTDHMJ.

2. Акимов В.Г. Роль дерматолога в ранней диагностике онкологических заболеваний. Consilium Medicum. 2015; 17(12): 68–72. [Akimov V.G. Dermatologist’s role in the early diagnosis of oncologic diseases. Consilium Medicum. 2015; 17(12): 68–72 (In Russ.)]. EDN: VIMUUN.

3. Yoo J., Choi J.K., Kim Y.D. et al. Outcome of stroke patients with cancer and nonbacterial thrombotic endocarditis. Stroke. 2020; 22(2): 245–53. https://dx.doi.org/10.5853/jos.2020.00619.

4. Gupta S., Bravo M.C., Heiman M. et al. Mathematical model of thrombin generation and bleeding phenotype in Amish carriers of Factor IX: C deficiency vs. controls. Thromb Res. 2019; 182: 43–50. https://dx.doi.org/10.1016/j.thromres.2019.07.020.

5. Le Bot A., Jego P., Donal E. et al. Non-infective endocarditis. Rev Med Interne. 2018; 39(10): 782–91.https://dx.doi.org/10.1016/j.revmed.2018.03.020.

6. Dipasco P.J., Misra S., Koniaris L.G., Moffat F.L. Jr. Thrombophilic state in cancer, part 1: Biology, incidence, andriskfactors. J Surg Oncol. 2011; 104(3): 316–22. https://dx.doi.org/10.1002/jso.21925.

7. Терентьев В.П., Батюшин М.М., Дерижанова И.С., Гасанов М.З. Паранеопластический синдром. Ростов-на-Дону. 2010; 157 с. [Terentyev V.P., Batyushin M.M., Derizhanova I.S., Hasanov M.Z. Paraneoplastic syndrome. Rostov-on-Don. 2010; 157 рp. (In Russ.)].

8. Bedikian A., Vaidviesco M., Luna M. et al. Nonbacterial thrombotic endocarditis in cancer patients with or without concomitant disseminated intravascular coagulation. Med Pediatr Oncol. 1978; 4(2): 149–57. https://dx.doi.org/10.1002/mpo.2950040211.

9. Ягода А.В., Гладких Н.Н. Эндокард и клапаны сердца при системных ревматических болезнях. Рецензенты: Левитан Б.Н., Елисеева Л.Н. Ставрополь: Ставропольский государственный медицинский университет. 2021; 296 c. [Yagoda A.V., Gladkikh N.N. Endocardium and heart valves in systemic rheumatic diseases. Reviewers: Levitan B.N., Eliseeva L.N. Stavropol: Stavropol State Medical University. 2021; 296 рp. (In Russ.)]. ISBN: 978-5-89822-717-3. EDN: TZMWNC.

10. Комаров В.Т., Татарченко И.П. Дифференциальная диагностика инфекционного и неинфекционных тромботических эндокардитов. Клиническая медицина. 2001; 79(10): 17–21. [Komarov V.T., Tatarchenko I.P. Differential diagnosis of infectious and non-infectious thrombotic endocarditis. Klinicheskaya meditsina = Clinical Medicine. 2001; 79(10): 17–21 (In Russ.)].

11. Edoute Y., Haim N., Rinkevich D. et al. Cardiac valvular vegetations in cancer patients: Prospective echocardiographic study of 200 patients. Am J Med. 1997; 102(3): 252–58. https://dx.doi.org/10.1016/S0002-9343(96)00457-3.

12. Takeshita S., Ogata T., Mera Y. et al. Multiple thrombi in the heart in trousseau syndrome caused by pancreatic carcinoma. J Stroke Cerebrovasc Dis. 2018; 27(5): e75–77. https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.12.005.

13. Ягода А.В., Цветков В.С., Титоренко В.В. Два случая миксомы левого предсердия с артериальными и венозными тромбозами. Клиническая медицина. 1984; 62(11): 114–117. [Yagoda A.V., Tsvetkov V.S., Titarenko V.V. Two cases of left atrial myxoma with arterial and venous thrombosis. Klinicheskaya meditsina = Clinical Medicine. 1984; 62(11): 114–117 (In Russ.)].

14. Heija M., Raderer M., Zielinski C. Inhibition of metastasis by anticoagulants. J Natl Cancer Inst. 1999; 91(1): 22–36.https://dx.doi.org/10.1093/jnci/91.1.22.

15. Смолякова Р.М., Машевский А.А., Мавричев С.А. с соавт. Молекулярно-генетические аспекты патогенеза венозных тромбозов и тромбоэмболии легочной артерии. Онкологический журнал. 2007; 1(2): 54–62. [Smolyakova R.M., Mashevsky A.A., Mavrichev S.A. et al. Molecular and genetic aspects of the pathogenesis of venous thrombosis and pulmonary embolism. Onkologicheskiy zhurnal = Journal of Oncology. 2007; 1(2): 54–62 (In Russ.)]. EDN: RPUPYD.

16. Scozzafava J., Hussain M.S., Ahmed S.N., Khan K. Reccurent strokes in a 46-year-old woman: Rapidly progressive nonbacterial thrombotic endocarditis. Can Med Assoc J. 2006; 175(9): 1055–56. https://dx.doi.org/10.1503/cmaj.060499.

17. El-Shami K., Griffits E., Streif M. Nonbacterial thrombotic endocarditis in cancer patients: Pathogenesis, diagnosis, and treatment. Oncologist. 2007; 12(5): 518–23. https://dx.doi.org/10.1634/theoncologist.12-5-518.

18. Zingone A., Kuehl W.M. Pathogenesis of monoclonal gammopathy of undetermined significance (MGUS) and progression to multiple myeloma. Semin Hematol. 2011; 48(1): 4–12. https://dx.doi.org/10.1053/j.seminhematol.2010.11.003.

19. Клиническая онкогематология. Руководство для врачей. Под ред. М.А. Волковой. М.: Медицина. 2001; 576 с. [Clinical oncohematology. Guide for doctors. Ed. by Volkova M.A. Moscow: Meditsina. 2001; 576 рp. (In Russ.)]. ISBN: 5-225-04580-4.

20. Sallah S., Husain A., Wan J. et al. The risk of venous thromboembolic disease in patients with monoclonal gammopathy of undetermined significance. Ann Oncology. 2004; 15(10): 1490–94. https://dx.doi.org/10.1093/annonc/mdh385.

21. Srkalovic G., Cameron M.G., Rybicki L. et al. Monoclonal gammopathy of undetermined significance and multiple myeloma are associated with an increased incidence of venothromboembolic disease. Cancer. 2004; 101(3): 558–66.https://dx.doi.org/10.1002/cncr.20405.

22. Eby C.S. Bleeding and thrombosis risks in plasma cell dyscrasias. Hematol Am Soc Hematol Educ Program. 2007: 158–64.https://dx.doi.org/10.1182/asheducation-2007.1.158.

About the Autors

Alexander V. Yagoda, MD, professor, head of the Department of hospital therapy, Stavropol State Medical University of the Ministry of Healthcare of Russia. Address: 355017, Stavropol, 310 Mira St.
E-mail: alexander.yagoda@gmail.com
ORCID: https://orcid.org/0000-0002-5727-1640
Natalya N. Gladkikh, MD, professor, professor of the Department of hospital therapy, Stavropol State Medical University of the Ministry of Healthcare of Russia. Address: 355017, Stavropol, 310 Mira St.
E-mail: ngladkih@mail.ru
ORCID: https://orcid.org/0000-0003-4510-3604
Pavel V. Koroy, MD, professor, professor of the Department of hospital therapy, Stavropol State Medical University of the Ministry of Healthcare of Russia. Address: 355017, Stavropol, 310 Mira St.
E-mail: Paule75@yandex.ru
ORCID: https://orcid.org/0000-0001-6392-8461
Anna V. Rybas, PhD in Medical Sciences, associate professor of the Department of hospital therapy, Stavropol State Medical University of the Ministry of Healthcare of Russia. Address: 355017, Stavropol, 310 Mira St.
E-mail: rybasdoc@mail.ru
ORCID: https://orcid.org/0000-0001-5360-0913

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